Human Embryos and Preimplantation Genetic Technologies

  • ID: 4746005
  • Book
  • 584 Pages
  • Elsevier Science and Technology
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Regularly used to determine the health and viability of an embryo before in vitro fertilization, preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD) have been successfully employed to test embryonic cells for chromosomal abnormalities and genes related to specific diseases. However, the complex social, ethical, legal, regulatory, and public policy aspects associated with preimplantation assessment technologies continue to evolve and represent important areas for scholarly discussion.

Human Embryos and Preimplantation Technologies: Social, Legal, and Health Policy Dimensions of Assisted Reproduction, edited by leading experts in the field, Dr. E. Scott Sills and Dr. Gianpiero Palermo, stands as the first holistic analysis of PGD and PGS as practiced and regulated worldwide. In addition to scientific and technical aspects, the book provides international perspectives on the ethical, legal, religious, policy, and social implications of assisted reproduction technologies globally, including in Africa, Asia, Europe, North and South America, and Australia.

The book begins with a thorough overview of PGS and PGD, featuring chapters on the history of these technologies, ethics, and social perspectives including PGS and the LGBT community, feminism, family dynamics, and psychological and interpersonal factors involved with assessment. Part II considers the current state of PGD and PGS in 20 different sovereign nations and religious communities, employing data on reproductive tourism and elective sex selection of human embryos. Part III concludes the book with an analysis of public policy concerns, current challenges, and future directions of PGS and PGD.

- Provides in-depth discussion of PGD and PGS as practiced and regulated worldwide - Offers an accessible resource for researchers, medical professionals, patients, regulators, and policymakers seeking expert opinions on PGS and PGD - Chapters contributed by international clinicians, researchers, and thought leaders in the field of assisted reproductive technology
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1. Introduction-PGS + PGD: A historical background 2. Who is the ideal candidate for PGS? 3. PGS/PGD, ethics and the family 4. PGS and the Feminist Perspective 5. The changing social profile of PGS 6. PGS and the LGBT community 7. PGS and Impact on Offspring-Ethnographic Considerations 8. Psychological and Interpersonal Factors in Preimplantation Embryo Assessment 9. Saying no to PGS-A View from the Vatican 10. PGS concerns-An American perspective 11. PGS in Australia 12. PGS in Belgium 13. PGS in Canada 14. PGS in the Republic of Georgia 15. PGS and the Shiite 16. PGS in Iran 17. PGS in Israel 18. PGS in India 19. PGS in the Republic of Ireland 20. PGS in Japan 21. PGS in the Grand Duchy of Luxembourg 22. PGS in Malaysia 23. PGS in Mexico 24. PGS in Nigeria 25. PGS in Norway 26. PGS in New Zealand 27. PGS in Portugal and Brazil 28. PGS in the Russian Federation 29. PGS in Sweden 30. PGS in Thailand 31. PGS in Ukraine 32. PGS in the United Kingdom 33. Global PGS: Overview of Public Policy Concerns 34. PGS: Legislative Considerations & Future Directions

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Sills, E. Scott
E Scott Sills, MD, PhD is Medical Director at the Center for Advanced Genetics in Carlsbad, California. Dr. Sills is certified both by the American Board of Obstetrics and Gynecology and the National Board of Physicians & Surgeons and is in full-time IVF practice. He holds a PhD in molecular biology from London's University of Westminster and an MD degree from University of Tennessee.
Dr. Sills' research interests include bioethics, reproductive biology, minimal access fertility surgery, and health policy. He has led investigative teams from Europe and USA in the discovery of three human gene mutations, including a previously unknown androgen receptor defect. Dr. Sills was elected to membership in the Max Planck Society (Germany) and the Royal Society of Medicine (UK). He previously directed the research portfolio for Ireland's largest fertility clinic, The Sims Institute/Sims IVF (Dublin) and served on the faculty at the Royal College of Surgeons in Ireland. With medical licensure and registration in California, New York, and United Kingdom, Dr. Sills serves patients from around the world.
Palermo, Gianpiero
Gianpiero D. Palermo, MD, PhD is Director of Assisted Fertilization and Andrology at the Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine (CRM), Professor of Embryology in Obstetrics & Gynaecology, and the Blavatnik Distinguished Professor of Reproductive Medicine at Weill Cornell Medical College.

Dr. Gianpiero Palermo is internationally known as an innovator in reproductive medicine, having developed intracytoplasmic sperm injection (ICSI), a revolutionary procedure in which a single sperm is injected directly into the egg for fertilization. In recognition of his ground-breaking contribution to reproductive medicine, he has received prestigious awards, including the Serono Prize for Medical Research on chromosomal analysis of embryos; the Barbara Eck Menning Founder's Award from RESOLVE, the national infertility organization; the Shackman Memorial Lecture at Johns Hopkins; the Buckeye Lecture of the American Society of Andrology; the Jacob Heskel Gabbay Award in Biotechnology and Medicine; and the Russian Crystal Tube Award.

His current research includes molecular and genetic aspects of fertilization, follow-up of ICSI babies, and genetic aspects of male infertility, as well as devising new procedures to treat age-related female infertility, harvesting and differentiation of embryonic stem cells and in vitro maturation of male germ cells.
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