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Transdermal Drug Delivery - Technologies, Markets, and Companies

  • ID: 4748153
  • Report
  • December 2019
  • Region: Global
  • 300 Pages
  • Jain PharmaBiotech
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This report deals with transdermal drug delivery - an approach used to deliver drugs through the skin for therapeutic use as an alternative to oral,intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Nanoparticles as well as the use of physical agents to facilitate transcutaneous drug delivery is described. Microneedle and needleless technologies are also described. Transdermal technologies may be applied for several categories of pharmaceuticals used for the treatment of disorders of the skin or for systemic effect to treat diseases of other organs. Several transdermal products and applications include hormone replacement therapy, contraception, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. The market for transdermal drug delivery is analyzed according to technologies and therapeutic areas from 2018 to 2028. This market is analyzed according to geographical regions as well.

Benefits of this report

  • Up-to-date one-stop information on transdermal drug delivery
  • Description of 100 companies involved and 105 collaborations in this area
  • Market analysis 2018-2028
  • Market values in major regions
  • Strategies for developing markets for transdermal drug delivery
  • A selected bibliography of 200 publications
  • Text is supplemented by 22 tables and 18 figures

Who should read this report?

  • Biotechnology companies developing transdermal technologies
  • Drug delivery companies
  • Pharmaceutical companies interested in transdermal drug delivery
  • Pharmaceutical research institutes

The report contains information on the following:

  • Basics of Transdermal Drug Delivery
  • Transdermal Drug Delivery Technologies
  • Transdermal Therapeutics
  • Markets for Transdermal Drug Delivery
  • Companies involved in transdermal drug delivery
Note: Product cover images may vary from those shown
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0. Executive Summary  

1. Basics of Transdermal Drug Delivery  
Introduction  
Historical landmarks in transdermal drug delivery  
Anatomy and physiology of skin  
Skin metabolomics and transcutaneous passage of drugs
Transcutaneous absorption  
Transdermal versus other methods of drug delivery
Advantages of transdermal drug delivery  
First-Pass Effect
Drawbacks of transdermal delivery
Factors that influence transdermal drug delivery  
Rate of permeation across the skin  
Properties of the skin  
Properties of drugs
The role of pH and pharmacokinetics  
Intradermal disposition of drugs after topical application
Role of nanobiotechnology in understanding basis of transdermal delivery  

2. Transdermal Drug Delivery Technologies  
Introduction  
Local application formulations
Crystalline topical formulations  
Microemulsions for transdermal drug delivery
Nanoemulsions for transdermal drug delivery  
Transdermal gel technology  
Biphasix system
Penetration enhancers
Chemical enhancers  
Nitric oxide-based transdermal drug delivery
Ionic liquids for transdermal delivery of drugs against bacterial biofilms on skin  
Vesicular transdermal carriers  
Ethosomes  
Elastic vesicles for transdermal drug delivery  
Liposomes
Nanovesicles for transdermal drug delivery  
Transfersomes
Transdermal patches  
Adhesives for transdermal patches
Commercial development of transdermal patches  
Innovations in transdermal patches
e-Patch™ controlled release micropump system
Patchless Transdermal Delivery System
Metered-dose transdermal system  
Polymers for transdermal drug delivery
Polymer membranes in transdermal patches  
Film forming polymeric solutions
Crystal Reservoir System of Nitto Denko
Use of physical modalities to facilitate transdermal transport  
Transdermal electrotransport  
Electroporation  
Drug delivery by electroporation  
Cryoelectrophoresis
Iontophoresis  
Iontophoresis compared with electrophoresis  
Application of iontophoresis for drug delivery  
Patents in iontophoresis
Companies with technologies for drug delivery by iontophoresis  
Combination of electrophoresis and iontophoresis  
Dermaportation  
Radiofrequency-driven transdermal delivery
Microporation  
Transcutaneous drug delivery by electropulsation  
Companies involved in electroporation-based drug delivery
Electrode Scanning System  
Use of electrostatic force in skin patch technology
Multiple Absorption Kinetic System
Transdermal drug delivery facilitated by heat  
Controlled, heat-aided drug delivery
Ultrasound  
Magnetophoresis
Use of lasers for transdermal drug delivery  
Laser-induced microporation  
Transdermal drug delivery by laser-induced pressure waves  
Transdermal drug delivery by laser-assisted changes in skin  
Transdermal delivery by gas under pressure  
Transdermal delivery with PowderJect gas gun  
Microneedle assisted microparticle delivery by a gene gun  
Microscission induced by gas  
Role of microelectronics in transdermal drug delivery
Microneedles and dermal microinjection technologies
Applications of microneedles  
AdminPatch® microneedle array
Biodegradable microneedles  
Ceramic microneedle arrays  
Dissolvable microneedle patches
MicorCor  
Microneedle arrays for drug delivery
Microneedle patch
MicroPyramid™ microneedles  
Microstructured Transdermal Systems  
Microneedle Array Patch technology  
Microneedle transdermal chip  
Microneedle applicator device  
Nanoject™ microneedle technology  
Nanoneedle patch  
PatchPump
Polymer microneedles  
Silk microneedles
Tattooing for drug delivery
ZP Patch microprojections technology
Companies developing microneedles for transdermal drug delivery  
Needlefree injections
Glide SDI® solid dose injector  
Jet injection  
Mini-Ject needlefree delivery system  
MicroJet for painless injections  
Nanoliter-volume pulsed microjets  
SUMAVEL™ DosePro™ needle-less injection  
Skin ablation or abrasion for drug delivery
Nanotechnology-based transdermal drug delivery
Delivery of nanostructured drugs from transdermal patches  
Effect of mechanical flexion on penetration of bucky balls through the skin  
Nanobiotechnology for transdermal application
Nanoparticles and nanoemulsions for skin disorders  
Nanogels  
Nanopatches  
Hyaluronic acid for facilitating transdermal passage of nanoconstructs
Ionic nanoparticle technology  
SLN gel for treatment of skin disorders
Topical delivery of siRNA- nanoparticle conjugates  
Transdermal nanoparticle preparations for systemic effect  
Transdermal administration of nanocarriers
Nanotechnology-based transdermal vaccination and immunotherapy
Safety issues of applications of nanomaterial carriers on the skin
Comparison of transdermal drug delivery systems  
Transdermal drug design  
In vitro testing of transdermal drug delivery systems  
Commercially available skin models for transdermal drug testing  
FDA guidelines for post-approval changes in semisold topical drugs  
In vivo testing of drug delivery systems
Infrared spectroscopy for evaluation of transdermal drug delivery
Modeling of transport through the skin
Concluding remarks on transdermal drug delivery technologies
Future developments in transdermal drug delivery  

3. Transdermal Therapeutics 
Introduction  
Drugs that can be administered transdermally  
Approved transdermal products  
Drugs in clinical trials  
Skin disorders
Cutaneous leishmaniasis
Hair loss  
Iontophoretic drug delivery for nail disorders
Psoriasis  
Nanoemulsions for paclitaxel delivery in psoriasis  
Cardiovascular disorders  
Transdermal estrogen for prevention of atherosclerotic cardiovascular disease  
Transdermal drug delivery for angina pectoris  
Transdermal drug delivery for hypertension  
Transdermal clonidine  
Transdermal delivery of β-blockers for hypertension
Transdermal delivery of calcium channel blockers for hypertension  
Transdermal drug delivery for congestive heart failure
Transdermal beta blockers  
Transdermal anticoagulants  
Respiratory diseases
Asthma
Chronic obstructive pulmonary disease  
Neurological and psychiatric disorders  
Parkinson's disease  
Transdermal drug delivery for Parkinson's disease  
Transdermal levodopa delivery systems
Transdermal dopamine agonists for Parkinson's disease
Rotigotine for Parkinson disease  
Rotigotine for restless legs syndrome  
Transdermal administration of other drugs for Parkinson disease  
Depression
Antidepressants
Selective serotonin-reuptake inhibitors  
Transdermal fluoxetine  
Monoamine oxidase inhibitors
Transdermal selegiline
Trazodone hydrochloride
Venlafaxine  
Bupropion  
Bipolar disorder  
Transdermal lithium  
Schizophrenia
Transdermal haloperidol  
Transdermal risperidone for treatment of schizophrenia
Transdermal blonanserin for treatment of schizophrenia  
Restless legs syndrome  
Alzheimer's disease
Transdermal rivastigmine
Transdermal donepezil
Transdermal galantamine
Transdermal arecoline  
Transdermal nicotine for Tourette syndrome  
Attention deficit hyperactivity disorder
Transdermal methylphenidate  
Migraine  
Transdermal sumatriptan
Transdermal zolmitriptan  
Transdermal dihydroergotamine  
Epilepsy
Tinnitus/Vertigo
Transdermal nitroglycerin for vasospasm due to subarachnoid hemorrhage
Musculoskeletal disorders
Osteoporosis  
Transdermal alendronate  
Transdermal estrogen
Transdermal human parathyroid hormone
Osteoarthritis  
Transdermal therapy of diabetes  
Insulin delivery in diabetes by transdermal patches
Microneedle patch for glucose-responsive insulin delivery 
Patch monitoring system for insulin delivery
Sonic Applicator & Control Device for TDD of insulin  
V-Go® disposable insulin delivery device  
ViaDor System for TDD of insulin  
Companies developing devices for transdermal insulin delivery
Transdermal therapy of oral antidiabetic agents
Male disorders  
Erectile dysfunction
Topical and transdermal preparation for erectile dysfunction  
Hypogonadism in the male
Topical testosterone  
Benign prostatic hypertrophy
Tamsulosin TDS
Women's health
Female sexual arousal disorder
Menopause
Hormone replacement therapy for menopause
Effect of transdermal estradiol on bone density
Transdermal PTH for postmenopausal osteoporosis  
Transdermal testosterone for low libido in postmenopausal women  
Breast disorders  
Dysmenorrhea
Female infertility
Contraception  
Female contraception  
Ortho Evra™  
AG200-15  
BAY86-5016
Desogestrel
Male contraception
Transdermal progestin plus testosterone
Cancer  
Delivery of the photosensitizer drug δ-amino levulinic acid
Intradermal delivery of cancer vaccines by adenoviral vectors  
Nanoemulsion-based delivery of caffeine for skin cancer  
Topical interferon α2b for cervical cancer and precancerous lesions
Transcutaneous electroporation for delivery of anticancer drugs  
Transdermal delivery of peptide cancer vaccines
Transdermal drug delivery for prostate cancer  
Transdermal nitroglycerine for prostate cancer  
Transdermal estradiol gel for prostate cancer  
Transdermal leuprolide acetate for prostate cancer  
Transdermal drug delivery for breast cancer
Afimoxifene topical gel for breast cancer  
Pain  
Relief of pain associated with minor medical procedures  
Transdermal lidocaine relief of postherpectic neuralgia  
Lidoderm  
Lidopat®  
ZTlido
Transdermal capsaicin for relief of pain
Nonsteroidal antiinflammatory drugs  
Topical NSAIDs
Transdermal ketoprofen
Topical opioids
Cancer pain
Transdermal fentanyl  
Transdermal nitroglycerine as an adjuvant to opioids  
Transdermal buprenorphine  
Chronic pain of non-malignant origin
Transdermal local anesthetics
Postoperative pain  
Transdermal fentanyl for the management of postoperative pain  
Fibromyalgia  
Nanotechnology-based approved transdermal analgesic preparations  
Nausea and vomiting  
Motion sickness  
Postoperative vomiting  
Chemotherapy-induced nausea and vomiting  
Antiaging strategies  
Smoking cessation
Transdermal nicotine replacement
Use of nicotine patch for smoking cessation in pregnancy  
Other methods of nicotine replacement  
Other treatments for smoking cessation
Miscellaneous uses of transdermal drug delivery
Allergic rhinitis
Chronic fatigue syndrome  
Delivery of cannabinoids  
Overactive bladder and urinary incontinence  
Transdermal oxybutynin  
Viral infections
Transdermal nanoparticles for immune enhancement in HIV  
Transdermal IQP-0410 for HIV/AIDS  
Wound healing and ulcers  
Transdermal gene therapy
Transdermal delivery of plasmid DNA by electroporation
Transdermal gene therapy for drug addiction  
Transdermal antisense therapy  
Transdermal vaccination
The skin as an immune organ
Technologies for transdermal vaccination
Dissolvable microneedle array for vaccine delivery  
Electroporation for administering DNA vaccines  
Microneedles for transdermal delivery of vaccines  
Needle-free delivery of vaccines
Transcutaneous immunotherapy using nanodispersions  
Applications of transdermal vaccination  
HIV/AIDS vaccination by topical application
Transdermal DNA influenza vaccine
Transdermal Aβ vaccination for Alzheimer’s disease  
Transdermal vaccination for traveller’s diarrhoea  
Epicutaneous desensitization for food allergy
Peanut patch for peanut allergy  
Transdermal nutraceuticals  
Complications of transdermal therapy  
Adverse effects of drugs  
Overdose effect  
Skin complications  
MRI-induced skin burns from transdermal patches  

4. Markets for Transdermal Drug Delivery  
Introduction  
Global markets for drug delivery  
Geographical distribution of transdermal drug delivery markets  
Emerging transdermal drug delivery markets in Asia  
Transdermal technology markets in therapeutic areas  
Angina pectoris
Attention deficit hyperactivity disorder
Erectile dysfunction
Hypertension
Osteoporosis  
Pain therapeutics  
Parkinson's disease  
Smoking cessation  
Transdermal hormone replacement therapy for menopause  
Transdermal testosterone replacement therapy for hypogonadism in the male  
Transdermal contraceptive market
Markets according to transdermal technologies
Markets for microneedle-based transdermal drug delivery
Marketing strategies for transdermal drug delivery
Marketing advantages of transdermal drug delivery
Unmet needs in transdermal drug delivery  
Regulatory aspects that affect transdermal drug delivery markets
Future prospects of transdermal drug delivery  
Growth of new technologies used in transdermal drug delivery  
Prospects of transdermal delivery for drugs coming off patents
Transdermal delivery of biologicals
Transdermal delivery of cosmetics  

5. Companies involved in transdermal drug delivery  
Profiles of companies
Top companies in transdermal drug delivery
Collaborations

6. References

Tables
Table 1-1: Historical landmarks in the development of transdermal drug delivery  
Table 1-2: Transdermal vs oral and intravenous drug delivery
Table 1-3: Size ranges of molecules that can be delivered by transdermal route
Table 2-1: Technologies for transdermal drug delivery  
Table 2-2: Chemical enhancers of skin penetration  
Table 2-3: Drug-in-adhesive versus reservoir type of transdermal patch
Table 2-4: Companies with transdermal patches for drug delivery
Table 2-5: Companies with technologies for drug delivery by iontophoresis
Table 2-6: Companies involved in electroporation-based drug delivery  
Table 2-7: Companies developing microneedles for transdermal drug delivery
Table 2-8: Comparison of transdermal drug delivery systems
Table 3-1: Approved transdermal products  
Table 3-2: Transdermal drugs in clinical trials or approval process  
Table 3-3: Companies developing devices for transdermal insulin delivery  
Table 3-4: Selected transdermal systems GLP-1 antidiabetic agents
Table 4-1: Worldwide drug delivery market growth 2018 to 2028  
Table 4-2: Transdermal drug delivery markets for geographical regions 2018 to 2028
Table 4-3: Markets for transdermal products for therapeutic areas 2018-2028  
Table 4-4: Markets according to transdermal technologies 2018-2028
Table 4-5: Marketing strategies based on transdermal drug delivery technologies
Table 5-1: Top five companies in transdermal drug delivery
Table 5-2: Collaborations in transdermal drug delivery  

Figures
Figure 1-1: Basic structure of the skin
Figure 1-2: Passages of transcutaneous drug absorption  
Figure 1-3: Events governing transcutaneous drug absorption  
Figure 2-1: Basic structure and function of transdermal drug delivery systems
Figure 2-2: Transdermal system for delivery of liquid drugs  
Figure 2-3: Crystal Reservoir System of Nitto Denko
Figure 2-4: A schematic view of electroporation
Figure 2-5: Depiction of breakdown of the stratum corneum during electroporation  
Figure 2-6: A schematic drawing of Iontophoresis
Figure 2-7: SonoPrep ultrasonic skin permeation  
Figure 2-8: A a schematic sketch of PowderJect gas gun
Figure 2-9: Drug delivery using different types of microneedles (MN)
Figure 2-10: A schematic drawing of the microneedle patch
Figure 2-11: Preparation of solid-in-oil nanodispersion for transdermal application
Figure 3-1: Oral versus transdermal administration of a drug in Parkinson's disease  
Figure 3-2: Control functions and user interface of insulin patch monitoring system
Figure 3-3: Transcutaneous immunotherapy using nanodispersions  
Figure 3-4: Mechanism of action of epicutaneous immunotherapy
Figure 4-1: Unmet needs in transdermal drug delivery 

Note: Product cover images may vary from those shown
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