Prognostic Epigenetics, Vol 12. Translational Epigenetics

  • ID: 4753526
  • Book
  • 504 Pages
  • Elsevier Science and Technology
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Prognostic Epigenetics, Volume Twelve presents leading chapter authors from across the globe who bring readers from basic science to clinical application. Beginning with a thorough introduction to individual variability in epigenetic processes, lab technology and research methods, the role of DNA methylation, chromatin dynamics, histone modifications, and noncoding RNAs in epigenetic prognostics, the book then explores the epigenetic mechanisms associated with particular disorder prognostics, providing clinicians and researchers with effective tools for the identification and development of biomarkers. Neurological disorders, neurodegenerative disorders, asthma, allergies, metabolic syndromes, obesity, cardiovascular disorders, cancer, infectious disease, autoimmune disorders, and more are covered.

Concluding chapters focus on the role of epigenetic biomarkers in personalized medicine, as well as next steps in research and future challenges for the field.

  • Compiles all known information on prognostic epigenetics and its role in preventative medicine and drug discovery
  • Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis
  • Provides tools for the identification and development of prognostic biomarkers for a wide range of diseases
  • Enables clinicians, researchers and pharmacologists to improve preventative medicine and precision therapeutics
  • Features chapter contributions from leading international researchers
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1. It is more than simple genes: The epigenome is more powerful than your genome
2. Diagnostic, prognostic and therapeutic potential of the inter-individual variability in the major epigenetic processes: A Clinical Prospective
3. Technological advances in studying epigenetics biomarkers for clinical research
4. DNA methylation and Chromatin remodeling: Potential prognostic biomarker for disease diagnosis
5. Use of post-translational histone modifications for disease diagnosis
6. Use of non-coding RNAs as Clinical Biomarkers for disease diagnosis
7. The Epigenetic Landscape in Neurological and Neurodegenerative Disorders
8. Epigenetic Biomarkers in Asthma and Allergy
9. Epigenetics Biomarkers in Metabolic syndrome and Obesity
10. Chromatin landscape and Epigenetic biomarkers for clinical diagnosis and prognosis of Type 2 Diabetes mellitus
11. Epigenetic biomarkers in Cardiovascular disorders
12. Epigenetic biomarkers in Cancer
13. Epigenetics in Infectious diseases
14. Epigenetics of autoimmune disorders
15. Epigenetics of Birth defects
16. Epigenetics of adverse pregnancy outcomes
17. Epigenetic landscape of Infertility
18.  Epigenetic landscape of polycystic ovarian syndrome
19. Epigenetic biomarkers in ocular disorders
20. Epigenetic biomarkers in personalized medicine
21. Conclusions and Perspectives. Future Challenges and Prospects for Prognostic Epigenetics and personalized epigenomics
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