The Artificial Pancreas: Current Situation and Future Directions presents research on the top issues relating to the artificial pancreas (AP) and its application to diabetes. AP is a newer form of treatment to accurately and efficiently inject insulin, thereby significantly improving the patient's quality of life. By connecting a continuous glucose monitor (CGM) to a continuous subcutaneous insulin infusion using a control algorithm, AP delivers and regulates the most accurate amount of insulin to maintain normal glycemic values. Featured chapters in this book are written by world leaders in AP research, thus providing readers with the latest studies and results.
- Focuses on Type 1 Diabetes Mellitus (T1DM) that is primarily found in children and typically treated by means of a syringe or insulin pump
- Features research and results from top academic experimental groups, and from universities such as Harvard (USA), the University of Virginia (USA), the University of Padova (Italy), the University of Montpellier (France), and the Buenos Aires Institute of Technology (Argentina)
- Discusses clinical trials of AP from around the world, including the United States, the EU, Latin America, and Israel
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2. Getting IoT-ready
3. Multivariable AP with adaptive control
4. The ARG algorithm: clinical trials in Argentina
5. Use of intraperitoneal insulin delivery for artificial pancreas
6. Physiological models for artificial pancreas development
7. Deployment of modular MPC for type 1 diabetes control: the Italian experience 2008-2016
8. Integrating the clinical and engineering aspects of closed-loop control: the Virginia experience
9. Strategies to mitigate hypoglycaemia in the artificial pancreas
10. Multiple-signal artificial pancreas systems
11. Artificial pancreas in pediatrics
Ricardo S. Sánchez-Peña received the Electronic Engineer degree from the University of Buenos Aires (UBA, 1978) and the M.Sc. and Ph.D. from the California Institute of Technology (1986, 1988), both in Electrical Engineering. In Argentina, he worked since 1977 in different research institutions. He collaborated with NASA, the German (DLR) and Brazilian (CTA/INPE) space agencies. He was (Plenary) Full Professor at UBA (1989-2004), ICREA Senior Researcher at the UPC (2005-2009, Barcelona) and visiting Prof./Researcher at several Universities in the USA and EU. He consulted for companies in the USA, Spain, and Argentina. He published four books and more than 160 journal and conference papers. He received awards from NASA, IEEE, and the National Academy of Exact, Physical, and Natural Sciences of Argentina. He is Director of the Research and Ph.D. Program at the Buenos Aires Institute of Technology (ITBA) and Investigador Superior from CONICET. He has applied identification and control to acoustical, mechanical, aero, and astronautical engineering and currently to type 1 diabetes and neurobiology.
Cherñavvsky, Daniel R.
Daniel R. Cherñavvsky is Assistant Professor of Research in the Center for Diabetes Technology at the University of Virginia. The Center for Diabetes Technology is a multidisciplinary group of research academicians with specialties in Pediatrics, Endocrinology, Behavioral Medicine, Systems Engineering, Mathematics, and Statistics, working collaboratively for the advancement of technology for the treatment of type 1 diabetes. Currently, Dr. Cherñavvsky is leading several artificial pancreas studies in pediatric and young adult populations. In addition, Dr. Cherñavvsky collaborates with the International Artificial Pancreas (iAP) Study Group, which joins investigators from Italy, France, Israel, Argentina, and the USA. He had conducted the first-ever outpatient clinical study of a cell phone-based artificial pancreas system and performed US and international outpatients-based trials with different generations of the Artificial Pancreas system. Dr. Cherñavvsky's funded studies include summer and winter camps with adolescents evaluating the effect of exercise and type 1 diabetes. Dr. Cherñavvsky, a pediatric nephrologist and pediatric intensive care specialist graduate from the University of Buenos Aires, has conducted and designed clinical research projects for over 15 years in the USA. Since September 2016, he joined TypeZero Technologies, Inc., as a part time chief medical officer. Now he divides his time between academia, continuing his clinical research activities, and industry, where he is moving forward technological products aiming to optimize treatment for people with type 1 diabetes.