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Liquid Biopsy Research Tools, Services and Diagnostics: Global Markets

  • ID: 4758139
  • Report
  • Region: Global
  • 261 Pages
  • BCC Research
1 of 4

FEATURED COMPANIES

  • Accuragen, Inc.
  • Bio-Rad Laboratories Inc.
  • Dovetail Genomics Llc
  • Immunovia Ab
  • Novogene Co. Ltd.
  • Roche Holding Ag
  • MORE

Report Scope:

The scope of the report includes liquid biopsy technologies, applications, industry subsegments, biomarker technologies, major funding initiatives, patents, and companies. The market sizes for liquid biopsy diagnostics are given for 2017, 2018 and 2023 (forecasted).

This report reviews liquid biopsy biomarkers and technologies and provides background on why liquid biopsy is increasingly viewed as a replacement for, or a companion to, tissue biopsy. The report then discusses several of the significant large-scale research initiatives that are contributing to liquid biopsy development. Key forces driving the market are enumerated.

The structures of several important industry subsectors are reviewed, as well as major industry acquisitions and strategic alliances from January 2017 through November 2018. Industry subsectors analyzed include advanced sequencing instruments; droplet digital PCR (polymerase chain reaction); target enrichment; single-cell DNA polymerase; non-invasive prenatal testing (NIPT); fetal-cell NIPT; CTC (circulating tumor cell) capture and detection; and liquid biopsy.

The market for liquid biopsy diagnostics is analyzed in depth. The market is analyzed by application (cancer, reproductive health, transplant), biomarker type (nucleic acids, cells, extracellular vesicles, proteins), analysis platform (microarray, NGS, PCR, proteomics, and other), analysis purpose (screening/early detection, diagnosis, therapy guidance, monitoring), and geography (North America, Europe, Asia/Pacific, Rest of World).

Market data covers 2017, 2018 and 2023 (forecasted).

More than 175 companies in the liquid biopsy industry are profiled in this report.

The publisher provides a summary of the main industry acquisitions and strategic alliances from January 2017 through November 2018, including key alliance trends.

The Report Includes:

  • 32 data tables and 54 additional tables
  • Industry analysis of the liquid biopsy biomarkers and technologies market
  • Analyses of global market trends with data from 2017 to 2018, and projections of compound annual growth rates (CAGRs) through 2023
  • Characterization and quantification of market potential for liquid biopsy diagnostics by application, biomarker type, analysis platform, analysis purpose, and geographical region
  • Discussion of several significant large-scale research initiatives that are contributing to liquid biopsy market development
  • Examination of various conventional biopsy methods and highlight how liquid biopsy enabling technologies address the issues and are gaining significant traction with key opinion leaders
  • Coverage of significant patents and their allotments in each category, as well as major industry acquisitions and strategic alliances data
  • Company profiles of major manufacturers and suppliers of liquid biopsy research tools, services, and diagnostics, including Agilent Technologies Inc., Cygnus Biosciences, Illumina Inc., Oxford Nanopore, Qiagen, Quantum Biosystems, Roche and Thermo Fisher Scientific
Note: Product cover images may vary from those shown
2 of 4

FEATURED COMPANIES

  • Accuragen, Inc.
  • Bio-Rad Laboratories Inc.
  • Dovetail Genomics Llc
  • Immunovia Ab
  • Novogene Co. Ltd.
  • Roche Holding Ag
  • MORE

Chapter 1 Introduction

  • Study Goals and Objectives
  • Reasons for Doing This Study
  • Scope of Report
  • Information Sources
  • Methodology
  • Geographic Breakdown
  • Analyst's Credentials
  • Custom Research
  • Related Reports

Chapter 2 Summary

Chapter 3 Overview

  • Introduction
  • Report Scope
  • Liquid Biopsy Versus Traditional Biopsy
  • Markets
  • Forces Driving Growth
  • Key Trends
  • Industry

Chapter 4 Technology Background

  • Liquid Biopsy Biomarkers
  • Cancer Genomics
  • Non-Invasive Prenatal Testing
  • Circulating Tumor Cell Technologies
  • CTC Workflow
  • Cell Isolation Technologies
  • CTC Sample Preparation Technologies
  • CTC Downstream Analysis Technologies
  • Comparison of Liquid Biopsy with Conventional Biopsy
  • Cancer Testing
  • Prenatal Testing

Chapter 5 Liquid Biopsy Initiatives

  • Blood Profiling Atlas
  • Cancer-ID
  • CTC Trap Consortium
  • Early Cancer Detection Consortium
  • EpiFemCare
  • Human Cell Atlas
  • Immunomonitor Consortium
  • Integration of Imaging and Fluid-based Tumor Monitoring in Cancer Therapy Program
  • Liquid Biopsies and Imaging for Improved Cancer Care
  • Next-Generation Single-Cell Analysis Program
  • Population Sequencing Projects
  • Precancer Atlas
  • Precision Medicine Initiative
  • Single-Cell Proteomics and Lipidomics Project
  • TopMed
  • Worldwide Innovative Networking (WIN) Consortium
  • Single-Cell Research
  • Cambridge Single-Cell Analysis Core Facility
  • Harvard Medical School Single-Cell Core
  • Mayo Medical Genome Facility
  • National Center for Single-Cell Biology
  • Single-Cell Analysis Core
  • UC San Francisco Single-Cell Analysis Center

Chapter 6 Market Breakdown by End User

  • Introduction
  • Cancer Applications
  • Precision Medicine
  • Cancer Biomarker Status
  • Cancer Market Segments
  • Reproductive Health Applications
  • Transplant Diagnostics Applications

Chapter 7 Liquid Biopsy Industry

  • Advanced Sequencing Instruments Industry
  • Droplet Digital PCR Industry
  • Target Enrichment and Amplification Industry
  • Single-Cell DNA Polymerase Industry
  • Non-Invasive Prenatal Testing Industry
  • Fetal Cell NIPT Industry
  • CTC Capture and Detection Industry
  • Liquid Biopsy Assay Industry

Chapter 8 Industry Acquisitions and Strategic Alliances

  • Acquisitions
  • Strategic Alliances
  • Key Trends
  • 2017 Alliances
  • 2018 Alliances

Chapter 9 Liquid Biopsy Markets

  • Forces Driving Growth
  • Liquid Biopsy Market by Indication
  • Liquid Biopsy Market by Biomarker Type
  • Liquid Biopsy Market by Analysis Platform
  • Liquid Biopsy Market by Analysis Purpose
  • Non-Invasive Prenatal Testing Market
  • Cancer Markets
  • Cancer Market by Indication
  • Cancer Market by Analysis Purpose
  • Cancer Market by Biomarker Class
  • Cancer Market by Analysis Method
  • Breast Cancer Market
  • Colorectal Cancer Market
  • Hematological Cancer Market
  • Lung Cancer Market
  • Pan-cancer Market
  • Transplant Markets
  • Regional Market Analysis

Chapter 10 Patent Review/ New Developments

  • Circulating Tumor Cell Patents
  • Exosome Patents
  • Cell-free DNA Patents
  • Liquid Biopsy and Sequencing-related Patent Issues

Chapter 11 Company Profiles

  • Accuragen, Inc.
  • Adaptive Biotechnologies Inc.
  • Advanced Cell Diagnostics Inc.
  • Agilent Technologies Inc.
  • Akadeum Life Sciences
  • Alcediag
  • Amoy Diagnostics Co. Ltd.
  • Angle Plc
  • Apocell Inc.
  • Apostle Inc.
  • Arcedi Biotech Aps
  • Arup Laboratories
  • Asuragen Inc.
  • Atreca Inc.
  • Aviva Biosciences
  • Baylor Genetics
  • Becton, Dickinson And Co.
  • Bellwether Bio Inc.
  • Berry Genomics Co. Ltd.
  • Bgi Shenzhen
  • Biocartis Nv
  • Biocept Inc.
  • Biocore Co. Ltd.
  • Biodesix Inc.
  • Biofluidica Inc.
  • Biogazelle
  • Biomarx Inc.
  • Bio-Rad Laboratories Inc.
  • Bio-Techne Ltd.
  • Biovendor-Laboratorni Medicina A.S.
  • Bluestar Genomics Inc.
  • Boreal Genomics
  • Cancer Genetics Inc.
  • Caredx Inc.
  • Cegat Gmbh
  • Cellmax Life
  • Cell Microsystems Inc.
  • Celsee Diagnostics
  • Chronix Biomedical
  • Circulogene Theranostics
  • Circulomics Inc.
  • Clinical Genomics Technologies
  • Codiak Biosciences
  • Color Genomics
  • CS Genetics Ltd.
  • Cygnus Biosciences Co. Ltd.
  • Cynvenio Biosystems Inc.
  • Cytotrack Aps
  • Datar Cancer Genetics Ltd.
  • Diacarta Inc.
  • Diagnologix Llc
  • Diagnomics
  • Direct Genomics Co. Ltd.
  • DNA Electronics Ltd.
  • Dnalytics
  • Dnanexus Inc.
  • Dovetail Genomics Llc
  • Envision Genomics
  • Epic Sciences Inc.
  • Eurofins Scientific
  • Exact Sciences Corp.
  • Exosome Sciences Inc.
  • Expedeon Ag
  • Ezlife Bio Inc.
  • Fabric Genomics
  • Fluxion Biosciences Inc.
  • Freenome Inc.
  • Genapsys Inc.
  • Genedx Inc.
  • Geneseq Biosciences Pty Ltd.
  • Genetics Research Llc
  • Genomatix Gmbh
  • Genomic Health Inc.
  • Genomoncology
  • Genospace
  • Genexosome Technologies Inc.
  • Gigagen Inc.
  • Golden Helix
  • Grail Inc.
  • Guardant Health Inc.
  • Helitec
  • Helix Opco Llc
  • HTG Molecular Diagnostics Inc.
  • Illumina Inc.
  • Immunovia Ab
  • Inex Innovations Exchange Pte. Ltd.
  • Inivata Ltd.
  • Interpace Diagnostics Llc
  • Invitae Inc.
  • Invivoscribe Inc.
  • JBS Science Inc.
  • Koninklijke Philips N.V.
  • Laboratory Corp. Of America Inc.
  • Lexent Bio Inc.
  • Lucence Diagnostics Pte. Ltd.
  • Mammoth Biosciences Inc.
  • Mdna Life Sciences Inc.
  • Mdxhealth Inc.
  • Medgenome Labs Pvt. Ltd.
  • Medomics Llc
  • Menarini Silicon Biosystems Spa
  • Merck Kgaa
  • Molecular Health Gmbh
  • Myriad Genetics Inc.
  • Namocell Inc.
  • Nanostring Technologies Inc.
  • Nanoview Biosciences Inc.
  • Natera Inc.
  • Naveris Inc.
  • Neogenomics Laboratories
  • New England Biolabs
  • New Oncology Gmbh
  • Nipd Genetics
  • N-Of-One Inc.
  • Novogene Co. Ltd.
  • Nugen Technologies Inc.
  • Nuprobe Inc.
  • NX Prenatal Inc.
  • Oncocyte Corp.
  • Oncodna S.A.
  • Oxford Nanopore Technologies Ltd.
  • Pacific Biosciences Of California Inc.
  • Pangaea Oncology
  • Paradigm Diagnostics Inc.
  • Parseq Lab Co. Ltd.
  • Pathway Genomics Corp.
  • Personal Genome Diagnostics Inc.
  • Pieriandx
  • Portable Genomics Llc
  • Precipio Inc.
  • Predicine Inc.
  • Premaitha Health Plc
  • Prenetics
  • Provista Diagnostics Inc.
  • Qiagen Nv
  • Quantapore Inc.
  • Quantum Biosystems Inc.
  • Quantumdx
  • Quest Diagnostics Inc.
  • Rarecells Sas
  • Rarecyte Inc.
  • Real Time Genomics Inc.
  • Resolution Bioscience Inc.
  • Roche Holding Ag
  • Screencell
  • Seekin
  • Sengenics Ltd.
  • Sequencing.Com
  • Seven Bridges Genomics Inc.
  • Singlera Genomics Inc.
  • Sophia Genetics
  • Spera Medical
  • Sphere Fluidics Ltd.
  • Stilla Technologies
  • Strand Life Sciences Pvt. Ltd.
  • Stratos Genomics Inc.
  • Syapse
  • Sysmex Inostics Gmbh
  • Tai Diagnostics Inc.
  • Takara Bio Inc.
  • Thermo Fisher Scientific Inc.
  • Thorne Diagnostics Inc.
  • Transplant Genomics
  • Trovagene Inc.
  • Twinstrand Biosciences
  • Two Pore Guys Inc.
  • Tymora Analytical Operations Llc
  • Ubiquity Genomics Inc.
  • Vortex Biosciences
  • Xing Technologies Llc
  • Vela Diagnostics
  • Volitionrx
  • Vortex Biosciences
  • Yikon Genomics Co. Ltd.

List of Tables
Summary Table: Global Liquid Biopsy Market, by Disease Class, Through 2023
Table 1: Liquid Biopsy Sample Types
Table 2: Liquid Biopsy Report Scope
Table 3: Global Liquid Biopsy Market, by Analysis Type, Through 2023
Table 4: Forces Driving Growth
Table 5: Key Trends in Liquid Biopsy Market
Table 6: Liquid Biopsy Industry Subsectors
Table 7: Liquid Biopsy Biomarker Classes
Table 8: Single-Cell Analysis to Identify Cancer Driver Mutations
Table 9: Genomics-based Oncology Workflow
Table 10: Unique Challenges of CTC Capture and Analysis
Table 11: CTC Workflow
Table 12: Cell Differentiators
Table 13: Cell Isolation Technologies
Table 14: CTC Sample Preparation Technologies
Table 15: Single-Cell Analysis Technologies
Table 16: Estimated Annual Solid Biopsy Procedures Performed in the United States for Selected Cancers
Table 17: Main Risks for Needle-based Tissue Biopsies
Table 18: Factors in Tissue Biopsy
Table 19: Prenatal Invasive Testing Technologies
Table 20: Invasive Versus Non-invasive Prenatal Technologies
Table 21: Key Liquid Biopsy Research and Development Programs
Table 22: Single-Cell Core Research Facilities
Table 23: Source of Foreign Biomarkers for Liquid Biopsy Applications
Table 24: Personalized Medicine Driven by Common Cancer Genetic Mutations
Table 25: Cancer Liquid Biopsy Biomarker Clinical Status
Table 26: Cancer Liquid Biopsy Market Segments
Table 27: Reproductive Health Screening Applications
Table 28: Ethical Issues Associated with NIPT
Table 29: Transplant Diagnostics Applications
Table 30: Key Segments and Trends within the Liquid Biopsy Industry
Table 31: Advanced Sequencing Industry Company Positioning
Table 32: End-to-End Sequencing Approaches
Table 33: Advantages of Droplet Digital PCR for Single-Cell Analysis
Table 34: Digital PCR Liquid Biopsy Industry
Table 35: Target Enrichment Industry
Table 36: Single-Cell DNA Polymerase Industry
Table 37: NIPT Industry
Table 38: Estimated Market Share for NIPT, 2018
Table 39: Germany NGS-based Non-invasive Prenatal Diagnostic Companies, 2017
Table 40: NIPT Test Licensing, by Country
Table 41: Fetal Cell NIPT Industry
Table 42: CTC Separations Industry
Table 43: Liquid Biopsy Assay Industry: Company Focus
Table 44: Example of NGS-based Liquid Biopsy Market Differentiation
Table 45: Liquid Biopsy Industry Acquisitions, January 2017-November 2018
Table 46: Liquid Biopsy Strategic Alliances, January 2017-November 2018
Table 47: Liquid Biopsy Key Forces Driving Growth and Implications, 2023
Table 48: Global Liquid Biopsy Market, by Indication, Through 2023
Table 49: Global Liquid Biopsy Market, by Biomarker Type, Through 2023
Table 50: FDA-Approved or CE-Marked Tests with Epigenetic Component
Table 51: Global Liquid Biopsy Market, by Analysis Platform, Through 2023
Table 52: Global Liquid Biopsy Market, by Analysis Purpose, Through 2023
Table 53: Global NIPT Market, by Analysis Purpose, Through 2023
Table 54: Global NIPT Market, by Risk Type, Through 2023
Table 55: Global NIPT Market, by Biomarker Class, Through 2023
Table 56: Global NIPT Market, by Analysis Method, Through 2023
Table 57: Limitations of Solid Biopsy in Cancer Applications
Table 58: Low-Frequency Mutation Detection
Table 59: Global Liquid Biopsy Cancer Market, by Indication, Through 2023
Table 60: Five-year Survival Rate for Ovarian Cancer
Table 61: National Institutes of Health Liquid Biopsy Early Detection Initiative
Table 62: Molecular Thyroid Nodule Classifier Test Company Positioning
Table 63: Global Liquid Biopsy Cancer Market, by Analysis Purpose, Through 2023
Table 64: MRI and Liquid Biopsy Methods
Table 65: Early Detection Tissue of Origin Approaches
Table 66: Global Liquid Biopsy Cancer Market, by Biomarker Class, Through 2023
Table 67: Global Liquid Biopsy Cancer Market, by Analysis Method, Through 2023
Table 68: Global Breast Cancer Liquid Biopsy Market, by Analysis Method, Through 2023
Table 69: Global Colorectal Cancer Liquid Biopsy Market, by Analysis Method, Through 2023
Table 70: Hematological Cancer Market, by Analysis Method, Through 2023
Table 71: Global Lung Cancer Liquid Biopsy Market, by Analysis Method, Through 2023
Table 72: Global Pan-cancer Liquid Biopsy Market, by Analysis Method, Through 2023
Table 73: Global Liquid Biopsy Transplant Market, by Analysis Purpose, Through 2023
Table 74: Global Liquid Biopsy Transplant Market, by Organ Type, Through 2023
Table 75: Transplant Procedures Performed in the United States, 2016 to 30 Sept. 2018
Table 76: Global Liquid Biopsy Transplant Market, by Analysis Method, Through 2023
Table 77: Global Liquid Biopsy Transplant Market, by Biomarker Class, Through 2023
Table 78: Global Liquid Biopsy Market, by Region, Through 2023
Table 79: Global Cancer Liquid Biopsy Market, by Region, Through 2023
Table 80: Global NIPT Liquid Biopsy Market, by Region, Through 2023
Table 81: Global Transplant Liquid Biopsy Market, by Region, Through 2023
Table 82: Patent Activity for Circulating Tumor Cells (CTCs), by Country/Region, 2008-2018
Table 83: Patent Activity for Exosomes, by Country/Region, 2008-2018
Table 84: Patent Activity for Cell-free DNA (cfDNA), by Country/Region, 2008-2018
Table 85: Status of Liquid Biopsy and Sequencing-related Patent Disputes

List of Figures
Summary Figure: Global Liquid Biopsy Market, by Disease Class, 2017-2023
Figure 1: How Cancer Genomics Drives Liquid Biopsy

Note: Product cover images may vary from those shown
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  • Accuragen, Inc.
  • Adaptive Biotechnologies Inc.
  • Advanced Cell Diagnostics Inc.
  • Agilent Technologies Inc.
  • Akadeum Life Sciences
  • Alcediag
  • Amoy Diagnostics Co. Ltd.
  • Angle Plc
  • Apocell Inc.
  • Apostle Inc.
  • Arcedi Biotech Aps
  • Arup Laboratories
  • Asuragen Inc.
  • Atreca Inc.
  • Aviva Biosciences
  • Baylor Genetics
  • Becton, Dickinson And Co.
  • Bellwether Bio Inc.
  • Berry Genomics Co. Ltd.
  • Bgi Shenzhen
  • Bio-Rad Laboratories Inc.
  • Bio-Techne Ltd.
  • Biocartis Nv
  • Biocept Inc.
  • Biocore Co. Ltd.
  • Biodesix Inc.
  • Biofluidica Inc.
  • Biogazelle
  • Biomarx Inc.
  • Biovendor–Laboratorni Medicina A.S.
  • Bluestar Genomics Inc.
  • Boreal Genomics
  • Cancer Genetics Inc.
  • Caredx Inc.
  • Cegat Gmbh
  • Cell Microsystems Inc.
  • Cellmax Life
  • Celsee Diagnostics
  • Chronix Biomedical
  • Circulogene Theranostics
  • Circulomics Inc.
  • Clinical Genomics Technologies
  • Codiak Biosciences
  • Color Genomics
  • CS Genetics Ltd.
  • Cygnus Biosciences Co. Ltd.
  • Cynvenio Biosystems Inc.
  • Cytotrack Aps
  • Datar Cancer Genetics Ltd.
  • Diacarta Inc.
  • Diagnologix Llc
  • Diagnomics
  • Direct Genomics Co. Ltd.
  • DNA Electronics Ltd.
  • Dnalytics
  • Dnanexus Inc.
  • Dovetail Genomics Llc
  • Envision Genomics
  • Epic Sciences Inc.
  • Eurofins Scientific
  • Exact Sciences Corp.
  • Exosome Sciences Inc.
  • Expedeon Ag
  • Ezlife Bio Inc.
  • Fabric Genomics
  • Fluxion Biosciences Inc.
  • Freenome Inc.
  • Genapsys Inc.
  • Genedx Inc.
  • Geneseq Biosciences Pty Ltd.
  • Genetics Research Llc
  • Genexosome Technologies Inc.
  • Genomatix Gmbh
  • Genomic Health Inc.
  • Genomoncology
  • Genospace
  • Gigagen Inc.
  • Golden Helix
  • Grail Inc.
  • Guardant Health Inc.
  • Helitec
  • Helix Opco Llc
  • HTG Molecular Diagnostics Inc.
  • Illumina Inc.
  • Immunovia Ab
  • Inex Innovations Exchange Pte. Ltd.
  • Inivata Ltd.
  • Interpace Diagnostics Llc
  • Invitae Inc.
  • Invivoscribe Inc.
  • JBS Science Inc.
  • Koninklijke Philips N.V.
  • Laboratory Corp. Of America Inc.
  • Lexent Bio Inc.
  • Lucence Diagnostics Pte. Ltd.
  • Mammoth Biosciences Inc.
  • MDNA Life Sciences Inc.
  • Mdxhealth Inc.
  • Medgenome Labs Pvt. Ltd.
  • Medomics Llc
  • Menarini Silicon Biosystems Spa
  • Merck Kgaa
  • Molecular Health Gmbh
  • Myriad Genetics Inc.
  • N-Of-One Inc.
  • Namocell Inc.
  • Nanostring Technologies Inc.
  • Nanoview Biosciences Inc.
  • Natera Inc.
  • Naveris Inc.
  • Neogenomics Laboratories
  • New England Biolabs
  • New Oncology Gmbh
  • Nipd Genetics
  • Novogene Co. Ltd.
  • Nugen Technologies Inc.
  • Nuprobe Inc.
  • NX Prenatal Inc.
  • Oncocyte Corp.
  • Oncodna S.A.
  • Oxford Nanopore Technologies Ltd.
  • Pacific Biosciences Of California Inc.
  • Pangaea Oncology
  • Paradigm Diagnostics Inc.
  • Parseq Lab Co. Ltd.
  • Pathway Genomics Corp.
  • Personal Genome Diagnostics Inc.
  • Pieriandx
  • Portable Genomics Llc
  • Precipio Inc.
  • Predicine Inc.
  • Premaitha Health Plc
  • Prenetics
  • Provista Diagnostics Inc.
  • Qiagen Nv
  • Quantapore Inc.
  • Quantum Biosystems Inc.
  • Quantumdx
  • Quest Diagnostics Inc.
  • Rarecells Sas
  • Rarecyte Inc.
  • Real Time Genomics Inc.
  • Resolution Bioscience Inc.
  • Roche Holding Ag
  • Screencell
  • Seekin
  • Sengenics Ltd.
  • Sequencing.Com
  • Seven Bridges Genomics Inc.
  • Singlera Genomics Inc.
  • Sophia Genetics
  • Spera Medical
  • Sphere Fluidics Ltd.
  • Stilla Technologies
  • Strand Life Sciences Pvt. Ltd.
  • Stratos Genomics Inc.
  • Syapse
  • Sysmex Inostics Gmbh
  • Tai Diagnostics Inc.
  • Takara Bio Inc.
  • Thermo Fisher Scientific Inc.
  • Thorne Diagnostics Inc.
  • Transplant Genomics
  • Trovagene Inc.
  • Twinstrand Biosciences
  • Two Pore Guys Inc.
  • Tymora Analytical Operations Llc
  • Ubiquity Genomics Inc.
  • Vela Diagnostics
  • Volitionrx
  • Vortex Biosciences
  • Xing Technologies Llc
  • Yikon Genomics Co. Ltd.
Note: Product cover images may vary from those shown
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