Molecular Nutrition: Vitamins presents the nutritional and molecular aspects of vitamins with a specific focus on vitamins A, B1 (thiamine), B2 (riboflavin), B# (niacin), B5 (pantothenic acid), B6, (pyridoxine), B7 (biotin), B9 (folate), B12 (colbamin), C, D, E, and K. As part of the Molecular Nutrition series, this book discusses introductory aspects and general coverage of vitamins and nutrition, the molecular biology of the cell, including signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis. Final sections cover genetic machinery and its function, transcriptional processes, homeostasis genes, cancer, gene expression, mutations, and more.
Emerging fields of molecular biology and important discoveries related to diet and nutritional health are also covered, rounding out the book.
- Summarizes molecular nutrition in health as related to vitamins
- Includes material on signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis
- Presents transcriptional processes, homeostasis genes, cancer, gene expression, mutations, the sodium-dependent multivitamin transporter, p53, p21, microRNAs, one carbon metabolism, nucleic acids, DNA methylation and polymorphisms
- Addresses emerging fields of molecular biology and presents important discoveries related to diet and nutritional health
- Covers Vitamins A, B, C, D, E, and K
- Discusses their impact on health relating to cancer, diabetes, arthritis, and aging
- Includes key facts, a mini dictionary of terms, and summary points
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II Molecular Biology of the Cell 6. Vitamin D Receptor in Arterial Ageing 7. Tocotrienol Regulation of AMPK in Cancer 8. Niacin and Hyperlipidemia 9. Folate Transporters in Placentas 10. Linking B-vitamins, Choline, and Stroke 11. Riboflavin (Vitamin B2) and Mitochondrial Energy 12. Pantothenic Acid (Vitamin B5) - Immunoreactive Neurons 13. Ascorbic Acid (Vitamin C) and Alzheimer's Disease 14. Vitamin B1 and the Pyruvate Dehydrogenase Complex 15. Vitamin D and Diabetes Mellitus: Vitamin D Metabolism, Alterations of Vitamin D Endo-paracrine System and their Relation to Oxidative/Nitrosative Stress, Inflammation, and Cell survival 16. Grape Seed Extract and Pyridoxine (Vitamin B6) 17. Cobalamin (Vitamin B12) Malabsorption 18. Pyridoxine (Vitamin B6) and Selenium Interactions: Implications for Human Health 19. Linking Vitamin E and Nitric Oxide in Liver Disease 20. Use of Methylcobalamin (Vitamin B12) in Pain 21. New Properties of Vitamin B6 or Pyridoxine in Experimental Oxidative Stress in the Brain 22. Thiamine (B1), Oxidative Stress, and Ethanol 23. Vitamin E: Novel Metabolites and Treatments 24. Vitamin E Structure and Forms/Analytical Methods 25. Pyruvate Carboxylase (PC) and the Biotin Carboxylase Domain 26. Application of Vitamins 27. Vitamins in Chronic Kidney Disease 28. Inflammatory Bowel Disorders and Fat-soluble Vitamins 29. Vitamin E and Reproductive Health 30. Vitamin B12 and Diabetes 31. Biotin Status Screening 32. Prostate Cancer and Applications of Vitamin K 33. Non-alcoholic Fatty Liver Disease and Use of Folate 34. Scenarios of Low Vitamin K Intakes
III Genetic Machinery and its Function 35. Transcriptional Control of Cells by Vitamin D 36. Transcriptome Analysis for Vitamin B3 (Niacin) and its Receptor GPR109A 37. Novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases 38. Vitamins and Epigenetics
Vinood B. Patel, BSc, PhD, FRSC, is currently a Reader in Clinical Biochemistry at the University of Westminster and honorary fellow at King's College London (Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics). He presently directs studies on molecular and metabolic pathways involved in organ disease, particularly related to subcellular organelles and cell death. He directs research into the role of nutrients, antioxidants, phytochemicals, minerals, toxins and macronutrients. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding oxidative stress. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King's College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr Patel is a nationally and internationally recognized liver researcher and was involved in several NIH-funded biomedical grants. Dr Patel has edited more than 20 biomedical books in the area of nutrition, health and disease and has published over 150 articles In 2014, he was elected as a Fellow to the prestigious Royal Society of Chemistry for bridging the academic and intellectual gap between chemistry and biological function.