Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche.
- Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances
- Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology
- Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease
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A historical perspective
2. Mathematical tools
3. Physical basis of chemistry
4. Chemical basis of biology
6. Structure analysis and visualization
7. Protein folding
8. DNA synthesis: Replication
10. RNA processing
12. DNA damage and repair
14. Membrane structure and function
15. Fundamentals of structural genomics
16. Cell signaling and systems biology
17. Macromolecular assemblies
18. Computational molecular biology
Subrata Pal obtained his bachelor's and master's degrees, both in physics, from Calcutta University. Subsequently, he pursued his predoctoral research in molecular biology and received a Ph. D. degree from the same university in 1982. He carried out his postdoctoral research in DNA replication and gene expression at two of the premiere institutions in the U. S. A. - the National Institutes of Health, Bethesda, Maryland and Harvard Medical School, Boston Massachusetts. At Harvard, he received a Claudia Adams Barr special investigator award for basic contribution to cancer research. Professor Pal has a long teaching experience at the undergraduate and graduate levels - the areas of his teaching include physics, molecular biology and genomics.