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Self-Organizing Neural Maps: The Retinotectal Map and Mechanisms of Neural Development

  • ID: 4768648
  • Book
  • 300 Pages
  • Elsevier Science and Technology
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Self-Organizing Neural Maps: The Retinotectal Map and Mechanisms of Neural Development: From Retina to Tectum describes the processes underlying how retinal fibers self-organize into an orderly visual map, highlighting almost a century of experiments. The formation of neural maps is a fundamental organizing concept in neurodevelopment and can shed light on developmental mechanisms and the function of genes elsewhere. This book is designed for neuroscientists of all backgrounds, working in all neuroscience subdisciplines, and presents a summary of research in the retinotectal field with the goal of forging a real synthesis on how mechanisms underlying neural development come together harmoniously to bring forth life as we know it. It is appropriate for a broad spectrum of neuroscientists and biomedical scientists with differing backgrounds and varied expertise.
  • Describes the mechanisms of the developmental wiring of the retinotectal system
  • Brings together the state of the art research in axon guidance and neuronal activity mechanisms in map formation
  • Focuses on topographical maps and inclusion of multiple animal models from fish to mammals
  • Explores molecular guidance and activity dependent cue components involved in neurodevelopment
  • Appropriate for neuroscientists in and outside the retinotectal field, with implications for neurobiology
  • Has great importance for those working with neurodevelopmental diseases, or in neurological and psychiatric translational research
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1. Overview and Basics of the Retinotectal Projection 2. Early Work Supports, but Also Contradicts, Rigid Chemoaffinity 3. The search for chemoaffinity molecules
verification of molecular gradients 4. Plasticity after surgical ablations shows the limits of chemoaffinity 5. Natural Plasticity
Analysis of the effects of divergent retinal and tectal growth on the projection 6. Specification and developmental genetics of Eph/ephrin gradients 7. Growth of retinal axons along the visual pathway 8. Genetic Analysis of the molecular gradients defining map formation 9. Activity mechanisms shape central retinal projections 10. Activity: Molecular signaling to growth mechanisms

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Schmidt, John T.
Dr. Schmidt is Professor Emeritus at the University of Albany (SUNY) in the Department of Biological Sciences. He has worked in the retinotectal area since the early 1970s and published more than 60 articles and chapters. For the last four decades, he was Professor of Biological Sciences at SUNY-Albany, serving for 25 years as the Director of the Center for Neuroscience Research. In the 1990s, he together with Professor Jonathan Wolpaw organized an international conference on the wider subject and edited a volume of the proceedings for the Annals of the New York Academy of Sciences, entitled Activity-Driven CNS Changes in Learning and Development (Volume 627). This volume was the NY Academy's bestselling issue of all time.
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