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Global DNA Sequencing: Research, Applied and Clinical Markets

  • ID: 4771276
  • Report
  • July 2021
  • Region: Global
  • 296 pages
  • BCC Research

FEATURED COMPANIES

  • ADMERA HEALTH
  • AGILENT TECHNOLOGIES INC.
  • AMBRY GENETICS
  • ASURAGEN INC.
  • ATHENA DIAGNOSTICS INC.
  • BAYLOR GENETICS
The report’s scope covers sequencing technologies, industries, applications, patents, initiatives and companies. The markets for sequencing services and products are given for the years 2020, 2021 and 2026.



This report reviews the leading sequencing technologies and describes why genetic variation is essential in clinical testing. It then discusses some of the important research initiatives that impact sequencing applications. The main market driving forces for sequencing services and products are listed and discussed. 

The report segments the sequencing markets by delivered format, including sequencing workflow products (sample preparation kits and reagents, informatics, and sequencing instruments and consumables) and sequencing services. The sample preparation reagents and kits market is fragmented by type, that is, DNA isolation and extraction; library preparation; and target enrichment. The sequencing instruments and consumables market are given by platform (NGS, Sanger and 3GS) and by product type (consumables, instruments).

The sequencing services market is segmented by end user applications (clinical, applied, research and development). Within sequencing services, the applied market is further analyzed by end user applications (biopharma, consumer, agriculture, microbiology, synthetic biology, population-scale genomics and others).

Also, within sequencing services, the clinical market is studied by disease category (clinical microbiology and infectious diseases, cardiovascular, mendelian disorders, metabolic/immune disorders, oncology, neurology, reproductive health and transplant medicine).

Industry sectors analyzed include long-read sequencing; sequencing instruments; target enrichment; informatics; blockchain; gene editing; liquid biopsy; reproductive health diagnostics; agriculture; consumer genomics; and DNA data storage.

By geography, the market has been fragmented into Europe, North America, Asia-Pacific (APAC) and the Rest of the World (RoW). For market estimates, data is provided for 2020 as the base year and for 2021, and it is forecast through year-end 2026. Estimated values used are based on product manufacturers’ and service providers’ total revenues. Projected and forecasted revenue values are in constant U.S. dollars that have not been adjusted for inflation.

Report Includes:
  • 85 tables
  • An updated review of the global market for DNA sequencing technologies and their applications in research, applied and clinical segments
  • Analyses of the global market trends, with data from 2020, estimates for 2021, and projections of compound annual growth rates (CAGRs) through 2026
  • Estimation of the market size and market forecast for DNA sequencing industry, and corresponding market share analysis by delivered format, product type, end use segment, application, disease category, and geography
  • Highlights of key market dynamics (DROs) for DNA sequencing, regulatory scenario, and impact of COVID-19 on the progress of this market
  • Discussion of market opportunities for DNA sequencing, industry structure, applications and business considerations of sequencing technologies, along with ongoing dramatic changes in the structure of MedTech industry
  • Review of the leading next-generation sequencing (NGS) technologies, emerging applications, and penetration of DNA sequencing-based diagnostics and research initiatives affecting the marketplace
  • Patent analysis for novel sequencing technologies, latest developments, clinical trials, and potential markets for future developments
  • Insight into the sequencing industry activities including major acquisitions and strategic alliances, competitive benchmarking of key sequencing industry participants and their growth strategies
  • Market share analysis of the key companies of the industry and their detailed company profiles including Agilent Technologies, Becton, Dickinson and Co., Bio-Rad, Danaher Corp., Illumina Inc., Merck KGaA, Roche, and Thermo Fisher
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • ADMERA HEALTH
  • AGILENT TECHNOLOGIES INC.
  • AMBRY GENETICS
  • ASURAGEN INC.
  • ATHENA DIAGNOSTICS INC.
  • BAYLOR GENETICS

Chapter 1 Introduction

  • Study Goals and Objectives
  • Reasons for Doing This Study
  • What's New in This Report
  • Scope of Report
  • Information Sources
  • Methodology
  • Geographic Breakdown
  • Analyst's Credentials
  • BCC Custom Research
  • Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Overview

  • Introduction
  • DNA Sequencing Markets
  • Sequencing Growth Driving Forces
  • Sequencing Applications
  • Sequencing Industry

Chapter 4 Technology Background

  • Importance of DNA
  • Genetic Variation and Analysis
  • History of Sequencing
  • Sequencing Technologies
  • Sanger Sequencing
  • Next-Generation Sequencing (NGS)
  • Short-Read Platforms
  • Long-Read Platforms
  • Informatics Technologies
  • Base Calling
  • Mapping to a Reference Sequence
  • Variant Analysis
  • Clinical Sequencing Technology Challenges

Chapter 5 Sequencing Initiatives

  • Sequencing Initiatives
  • R&D Initiatives and Programs
  • 1+ Million Genomes
  • Access to Comprehensive Genomic Profiling Coalition (ACGP)
  • Access to Treatment and Testing (ACTT)
  • Africa Pathogen Genomics Initiative
  • Blood Profiling Atlas
  • Cancer-ID
  • Cancer Moon Shots Program
  • China Precision Medicine Initiative
  • ClinGen
  • Early Cancer Detection Consortium
  • EpiFemCare
  • France Genomic Medicine Plan
  • Friends of Cancer Research Project
  • Genomic Medicine Sweden
  • HCA-Organoid
  • Human Cell Atlas
  • Human Immunomics Initiative
  • Immunomonitor Consortium
  • Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy Program
  • Intervene
  • Liquid Biopsies and Imaging for Improved Cancer Care
  • Liquid Biopsy-Based Malignant Tumor Early Screening Technology Research and Development Project
  • Lung-Map
  • Matchmaker Exchange
  • Metagenomics and Metadesign of Subways and Urban Biomes (MetaSub)
  • Medical Genome Initiative
  • Million Veteran Program (MVP)
  • MIND (Molecular Integration in Neurological Diagnosis)
  • MedSeq
  • National Microbiome Initiative (NMI)
  • Next Generation Single Cell Analysis Program
  • Precision Medicine Initiative
  • Prospective Registry of Multiplex Testing (PROMPT)
  • Quality Assurance Initiative Pathology (QuIP) Initiative
  • TopMed (Trans Omics for Precision Medicine)
  • Treehouse Childhood Cancer Initiative
  • Very Rare Cancer Consortium (VRCC)
  • Worldwide Innovative Networking (WIN) Consortium
  • Single-Cell Research
  • Cambridge Single-Cell Analysis Core Facility
  • Harvard Medical School Single-Cell Core
  • Mayo Medical Genome Facility
  • National Center for Single-Cell Biology
  • Next-Generation Single-Cell Analysis Program
  • Single-Cell Analysis Core
  • UC San Francisco Single-Cell Analysis Center
  • Population Sequencing Projects

Chapter 6 Impact of COVID-19 Pandemic

  • Introduction
  • Impact on MedTech
  • Elective and Noncritical Procedures
  • Shift in Manufacturing
  • Regulatory Delays, Clinical Trials and Product Launches
  • Supply Chain Disruptions
  • Impact of COVID-19 on DNA Sequencing

Chapter 7 Research and Applied Applications

  • Introduction
  • Research and Development Applications
  • Applied Applications
  • Direct to Consumer
  • Biopharma
  • Agriculture
  • Forensics
  • Microbiome
  • Synthetic Biology

Chapter 8 Clinical Applications

  • Introduction
  • Cancer Applications
  • Mendelian Disorders Applications
  • Reproductive Health Applications
  • Microbiology and Infectious Disease Applications
  • Complex Disorders Applications
  • Transplant Diagnostics Applications

Chapter 9 Sequencing Industry

  • Introduction
  • Sequencing Instruments Industry
  • Companies
  • Long-Read Sequencing Industry
  • Target Enrichment and Amplification Industry
  • Gene Editing Industry
  • Sequencing Informatics Industry
  • Liquid Biopsy Assay Industry
  • Reproductive Health Diagnostics Industry
  • Noninvasive Prenatal Testing (NIPT) Industry
  • Agriculture Industry
  • Consumer Genomics Industry
  • DNA Data Storage Industry

Chapter 10 DNA Sequencing Markets

  • Market Dynamics
  • Market Drivers
  • Market for DNA Sequencing
  • Sequencing Services Market
  • Sample Prep Kits and Reagents Market
  • Informatics Market
  • Sequencing Instruments and Consumables Market
  • Agriculture Market
  • Biopharma Market
  • Consumer Genomics Market
  • Microbiology Market
  • Population Genomics Market
  • Synthetic Biology Market
  • Clinical Diagnostic Sequencing
  • Cardiology Market
  • Clinical Microbiology and Infectious Disease Market
  • Mendelian Disorders Market
  • Metabolic/Immune Disorders Market
  • Neurology Market
  • Oncology Market
  • Reproductive Health Market
  • Transplant Market
  • Cancer Clinical Diagnostics Sequencing
  • Lung Cancer
  • Breast Cancer
  • Colorectal Cancer
  • Pan-Cancer
  • Other Cancers
  • Oncology Screening/Early Detection
  • Oncology Diagnosis
  • Oncology Therapy Guidance
  • Oncology Monitoring
  • Reproductive Health
  • IVF
  • Newborn Screening
  • Carrier Screening
  • NIPT
  • Transplant
  • Geographical Markets

Chapter 11 Patent Review/ New Developments

  • Patents on Circulating Tumor Cells
  • Patents on Exosomes
  • Patents on Cell-Free DNA
  • Patents Related to Biomarkers
  • Sequencing-Related Patent Disputes

Chapter 12 Competitive Landscape

  • Acquisitions
  • Strategic Alliances

Chapter 13 Company Profiles

  • ADMERA HEALTH
  • ADAPTIVE BIOTECHNOLOGIES INC.
  • AGILENT TECHNOLOGIES INC.
  • AMBRY GENETICS
  • ASURAGEN INC.
  • ATHENA DIAGNOSTICS INC.
  • BAYLOR GENETICS
  • BECTON, DICKINSON AND CO.
  • BERRY GENOMICS CO. LTD.
  • BGI SHENZHEN
  • BIODESIX INC.
  • BIO-RAD LABORATORIES INC.
  • CAREDX INC.
  • CARIS LIFE SCIENCES
  • CEGAT GMBH
  • CELLMAX LIFE
  • CENTOGENE AG
  • COOPERSURGICAL INC.
  • CYGNUS BIOSCIENCES CO. LTD.
  • DANAHER CORP.
  • DARUI BIOTECHNOLOGY CO. LTD.
  • DEVYSER AB
  • DIACARTA INC.
  • DNA ELECTRONICS
  • ELECTRONIC BIOSCIENCES
  • EPIC SCIENCES INC.
  • EUROFINS SCIENTIFIC
  • FRY LABORATORIES LLC
  • GENAPSYS INC.
  • GENDX BV
  • GENE BY GENE LTD.
  • GENOMATIX SOFTWARE GMBH
  • GENOME PROFILING LLC
  • GOLDEN HELIX
  • GRANDOMICS BIOSCIENCES CO. LTD.
  • GUARDANT HEALTH INC.
  • HELIX OPCO LLC
  • HISTOGENETICS LLC
  • HTG MOLECULAR DIAGNOSTICS INC.
  • ILLUMINA INC.
  • INEX INNOVATIONS EXCHANGE PTE. LTD.
  • INIVATA LTD.
  • INTERPACE DIAGNOSTICS LLC
  • INVIVOSCRIBE INC.
  • IREPERTOIRE INC.
  • KEW INC.
  • LABORATORY CORP. OF AMERICA INC.
  • MACROGEN INC.
  • MDXHEALTH INC.
  • MERCK KGAA
  • MYRIAD GENETICS INC.
  • NATERA INC.
  • NEOGENOMICS LABORATORIES
  • NEW ENGLAND BIOLABS
  • NGENEBIO CO., LTD.
  • NOVOGENE CO. LTD.
  • NUGEN TECHNOLOGIES INC.
  • OMNISEQ CORP.
  • OXFORD NANOPORE TECHNOLOGIES LTD.
  • PACIFIC BIOSCIENCES OF CALIFORNIA INC.
  • PARADIGM DIAGNOSTICS INC.
  • PARSEQ LAB CO. LTD.
  • PERKINELMER INC.
  • PERSONAL GENOME DIAGNOSTICS INC.
  • PERSONALIS INC.
  • PREDICINE INC.
  • PREVENTIONGENETICS INC.
  • QIAGEN N.V.
  • QUANTUM BIOSYSTEMS INC.
  • QUEST DIAGNOSTICS INC.
  • REAL TIME GENOMICS INC.
  • ROCHE HOLDING AG
  • SEEKIN
  • SEQUENCING.COM
  • SEVEN BRIDGES GENOMICS INC.
  • SISTEMAS GENOMICOS SL
  • SOPHIA GENETICS
  • TAKARA BIO INC.
  • THERMO FISHER SCIENTIFIC INC.
  • UBIQUITY GENOMICS INC.
  • VORTEX BIOSCIENCES
  • YOURGENE HEALTH PLC

Chapter 14 Appendix: Acronyms

List of Tables
Summary Table : Global Market for DNA Sequencing, by Major Segment, Through 2026
Table 1 : Global Market for DNA Sequencing, by Product Type, Through 2026
Table 2 : Market for DNA Sequencing Growth Driving Forces
Table 3 : Sequencing End Users and Applications
Table 4 : Key Sequencing Industry Participants, by Sector
Table 5 : DNA Chemical Building Blocks
Table 6 : DNA Translation and Transcription
Table 7 : Long-Range DNA Structure
Table 8 : Genetic Variant Types
Table 9 : Molecular Diagnostic Technology Platforms
Table 10 : Genome Coverage of PCR, Microarray and NGS Technology Platforms
Table 11 : DNA Sequencing Historical Timeline
Table 12 : Sequencing Technology Development, 1990-2020
Table 13 : Cost to Sequence a Single Human Genome, 2001-2021
Table 14 : Sequencing Technology Summary
Table 15 : Summary of Sanger Sequencing
Table 16 : Improvements in Sanger Sequencing
Table 17 : NGS Technologies
Table 18 : Illumina NGS Workflow
Table 19 : Thermo Fisher Scientific NGS Workflow
Table 20 : NGS Bioinformatics Workflow
Table 21 : Sequence Annotation Steps
Table 22 : Future Challenges in Implementing Clinical NGS
Table 23 : Key Sequencing Research and Development Programs
Table 24 : Single-Cell Core Research Facilities
Table 25 : Population Sequencing Projects
Table 26 : Number of Sequencing Projects in GOLD Database, 2018-2020
Table 27 : Main Sequencing Applications
Table 28 : Genetic Analysis Platform Comparison
Table 29 : Sequencing Impact on Agricultural Product Classes
Table 30 : Key Applications in Forensics/Human Identity Sequencing
Table 31 : Key Applications in Microbial Sequencing
Table 32 : Genetic Testing Scope
Table 33 : Key Applications for Sequencing-Based Diagnostics
Table 34 : Cancer Applications
Table 35 : Mendelian Disorders Applications
Table 36 : Reproductive Health Screening Applications
Table 37 : Ethical Issues Associated with NIPT
Table 38 : Microbiology/Infectious Disease Applications
Table 39 : Complex Disorder Applications
Table 40 : Transplant Diagnostics Applications
Table 41 : Subsectors within the Sequencing Industries
Table 42 : NGS and 3GS Industry Company Positioning
Table 43 : Long-Read Sequencing Industry
Table 44 : NGS Target Enrichment Industry
Table 45 : Gene Editing Tools Industry
Table 46 : Agricultural Gene Editing Industry
Table 47 : Sequencing Informatics Industry
Table 48 : Liquid Biopsy Assay Industry: Company Focus
Table 49 : Example of NGS-Based Liquid Biopsy Market Differentiation
Table 50 : NIPT Industry
Table 51 : Key Players in Synthetic Biology Agriculture Industry
Table 52 : Players in Consumer Genomics Industry
Table 53 : Key Forces Driving Growth in Market for DNA Sequencing and Their Implications
Table 54 : Global Market for DNA Sequencing, by Format, Through 2026
Table 55 : Global Market for Sequencing Instruments and Consumables, by Product Type, Through 2026
Table 56 : Global Market for Sequencing Instruments and Consumables, by Product Generation, Through 2026
Table 57 : Global Market for Sample Preparation, by Product Type, Through 2026
Table 58 : Global Market for Sequencing Services, by End User, Through 2026
Table 59 : Global Market for Applied Sequencing Services, by Application, Through 2026
Table 60 : Global Market for Clinical Diagnostic Sequencing, by Disease Category, Through 2026
Table 61 : NGS-Based Dilated Cardiomyopathy Test Providers
Table 62 : NGS-Based Infectious Disease Landscape
Table 63 : Multiple Sclerosis Diagnostic Technologies
Table 64 : Limitations of Tissue Biopsy in Cancer Applications
Table 65 : National Institutes of Health Liquid Biopsy Early Detection Initiative
Table 66 : Clinical Trials on Lung Cancer Liquid Biopsies
Table 67 : Five-Year Survival Rate for Ovarian Cancer
Table 68 : MRI and Liquid Biopsy Methods
Table 69 : Early Detection Tissue of Origin Approaches
Table 70 : Global Market for DNA Sequencing, by Region, Through 2026
Table 71 : North American Market for DNA Sequencing, by Country, Through 2026
Table 72 : North American Market for DNA Sequencing, by Major Segment, Through 2026
Table 73 : European Market for DNA Sequencing, by Country, Through 2026
Table 74 : European Market for DNA Sequencing, by Major Segment, Through 2026
Table 75 : Asia-Pacific Market for DNA Sequencing, by Country, Through 2026
Table 76 : Asia-Pacific Market for DNA Sequencing, by Major Segment, Through 2026
Table 77 : Rest of the World Market for DNA Sequencing, by Major Segment, Through 2026
Table 78 : Patent Activity on Circulating Tumor Cells (CTCs), by Country/Region, January 2010–June 2020
Table 79 : Patent Activity on Exosomes, by Country/Region, January 2010–December 2020
Table 80 : Patent Activity on Cell-Free DNA, by Country/Region, January 2010–December 2020
Table 81 : Patent Activity on Cancer Biomarkers, by Country/Region, January 2010–December 2020
Table 82 : Status of NGS-Based Liquid Biopsy Patent Disputes
Table 83 : Sequencing Industry Acquisitions
Table 84 : Sequencing Industry Strategic Alliances
Table 85 : Acronyms Used in the DNA Sequencing Industry

List of Figures
Summary Figure : Global Market for DNA Sequencing, by Major Segment, 2020-2026
Figure 1 : Agilent: Annual Revenue, 2018–2020
Figure 2 : Agilent: Revenue Share, by Region, 2020
Figure 3 : Agilent: Revenue Share, by Segment, 2020
Figure 4 : BD: Annual Revenue, 2018-2020
Figure 5 : BD: Revenue Share, by Geography, 2020
Figure 6 : BD: Revenue Share, by Segment, 2020
Figure 7 : Bio-Rad: Annual Revenue, 2018–2020
Figure 8 : Bio-Rad: Revenue Share, by Segment, 2020
Figure 9 : Danaher Corp.: Annual Revenue, 2018-2020
Figure 10 : Danaher Corp.: Revenue Share, by Region, 2020
Figure 11 : Danaher Corp.: Revenue Share, by Segment, 2020
Figure 12 : Illumina Inc.: Annual Revenue, 2018–2020
Figure 13 : Illumina Inc.: Revenue Share, by Region/ Country, 2020
Figure 14 : Illumina Inc.: Revenue Share, by Segment, 2020
Figure 15 : Merck KGaA: Annual Revenue, 2019 and 2020
Figure 16 : Merck KGaA: Revenue Share, by Region, 2020
Figure 17 : Merck KGaA: Revenue Share, by Segment, 2020
Figure 18 : Thermo Fisher Scientific: Annual Revenue, 2019 and 2020
Figure 19 : Thermo Fisher Scientific: Revenue Share, by Segment, 2020

Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • ADMERA HEALTH
  • AGILENT TECHNOLOGIES INC.
  • AMBRY GENETICS
  • ASURAGEN INC.
  • ATHENA DIAGNOSTICS INC.
  • BAYLOR GENETICS

The DNA sequencing industry has achieved notable growth from its beginnings to become a vital sector in the life sciences industry. The total number of human genomes sequenced reached around 1.5 million in January 2019 (less than 0.02% of the global human population). It is estimated that population-scale projects alone will increase that figure to more than 13.5 million genomes sequenced by 2023. The non-human species sequenced as of January 2019 was less than 0.01% of all species. This data suggests a significant future upside for DNA sequencing across research, agriculture, metagenomics, synthetic biology and clinical applications, among others.

Sequencing plays a central role in many life science megatrends, including synthetic biology, precision medicine, population and consumer genomics; tissue-agnostic drugs; liquid biopsy; blockchain technologies, gene editing and a shift toward consumerism. These major trends favor rising sequencing adoption and growth in the future.

For example, in clinical diagnostics, there is a move toward a more consumer-focused model. This will propel the demand for genomics technologies as consumers will want to better understand the role that genetic variations and genes have in their future health outcomes.

The key developments in three key sequencing sectors - applied, research and clinical - add to the DNA sequencing growth story.

Significant developments in the research space include the growth of large-scale sequencing initiatives and support for sequencing by major governmental funding agencies.

Major developments in the applied space include the proliferation of population-scale sequencing projects around the globe, the use of sequencing by biopharma for the selection of patients for clinical trials of precision medicines and an increase in synthetic biology and agriculture applications.

Population-scale sequencing projects have various positive effects on the sequencing market. These projects give insight into how genetic variation contributes to disease diagnosis, risk prediction and treatment; advance knowledge about genetic variation within and across populations; and facilitate the development of new sequencing tools and analysis methods.

Significant developments in the clinical space include the launch and fast growth of NIPT, companion diagnostics for tissue-agnostic drugs and for drug development, and a growing installed base of sequencing instruments for genetic testing. Important clinical sequencing applications include reproductive health, oncology, rare and undiagnosed diseases, and transplant medicine.

Genomics (including sequencing) is a key medical technology. Once the human genome had been sequenced, medical researchers were able to start identifying disease-causing variations in the genetic code. Drugs could then be targeted to specific genes, offering tailored treatments. This also opened up a market opportunity in clinical trials to select a subgroup of patients who will respond to the drug. As a result, drugs that may have failed clinical trials due to side effects among a general population could make their way through the trials with a genetically targeted subgroup.

Note: Product cover images may vary from those shown
  • ADAPTIVE BIOTECHNOLOGIES INC.
  • ADMERA HEALTH
  • AGILENT TECHNOLOGIES INC.
  • AMBRY GENETICS
  • ASURAGEN INC.
  • ATHENA DIAGNOSTICS INC.
  • BAYLOR GENETICS
  • BECTON, DICKINSON AND CO.
  • BERRY GENOMICS CO. LTD.
  • BGI SHENZHEN
  • BIO-RAD LABORATORIES
Note: Product cover images may vary from those shown
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