Recent Advances in Carbohydrate Chemistry: Biomedical and Materials Science Applications presents the most recent synthetic methodologies in carbohydrate chemistry. The book emphasizes structural and biosynthetic similarities and distinct differences among sugar acids to provide the background information needed for the development of inhibitors, vaccines and antimicrobials with novel modes of action. Lastly, polysaccharides, which are commonly modified chemically to attain new properties are examined. An introduction and relevant background to synthetic glycoconjugate vaccines is included, with a focus on synthetic carbohydrate-base vaccines licensed or under development.
The work is ideal for researchers working as synthetic organic chemists, as well as conjugation and protein chemists, immunologists and microbiologists-in both academia or industry.
- Demonstrates the importance of carbohydrate chemistry for the access of carbohydrate-based natural molecules
- Covers monosaccharide syntheses and transformations towards biologically active small molecular entities and glycomimetics
- Emphasizes structural and biosynthetic similarities and shows synthetic approaches to ulosonic acids
- Provides information on the development of inhibitors, vaccines and antimicrobials
- Presents the most recent findings on polysaccharide synthesis and bioapplications, such as carbohydrate-based vaccines
I. Monosaccharide chemistry toward molecular diversity--Recent findings 1. Perspective on the transformation of carbohydrates under green and sustainable reaction conditions 2. Hydroxymethylfurfural (HMF) and Glucosyloxymethylfurfural (GMF) in Multi-Component Reactions 3. Alkynedicobalt complexes in carbohydrates: Synthetic applications 4. Molecular Diversity Through Gold-catalysis on Saccharide Building Blocks 5. Glycomimetics with unnatural glycosidic linkages 6. Synthetic Approaches to Functionalized Oxepanes and Azapanes from Monosaccharides 7. N- and C-Glycopyranosyl Heterocycles as Glycogen Phosphorylase Inhibitors 8. Recent developments in synthetic methods for sugar phosphates, phosphonates and analogous P-containing compounds
II. Advances in chemical synthesis and biosynthesis of bacterial glycans 9. Prokaryotes: Sweet proteins do matter 10. Glycan ligation reactions in the periplasmic space 11. Synthesis of bioactive lipid A and analogues 12. Synthesis of lipopolysaccharide core fragments 13. Synthesis of oligosaccharides related to potential bioterrorist pathogens 14. Techoic acid chemistry for vaccine applications 15. NMR characterization of bacterial glycans and glycoconjugate vaccines
III. Structure-function relationships in polysaccharides 16. Polysaccharides: chemical synthesis 17. Linear and cyclic amylose, beyond natural 18. Modification of xanthan in the ordered and disordered states 19. Derivatized polysaccharides on silica and hybridized with silica in chromatography and separation
a mini review
IV. Synthetic carbohydrate-based vaccines: present and future 20. Glycoconjugate vaccines, production and characterization 21. Antifungal glycoconjugate vaccines 22. Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development 23. Glyconanoparticles as versatile platforms for vaccine development
Professor of Organic Chemistry since 1984; Professor of Carbohydrate Chemistry at Faculdade de Ciências da Universidade de Lisboa (3rd year course of the Graduation in Chemistry since 2001), editor of the RSC book series Carbohydrate Chemistry - Chemical and Biological Approaches (since 2008); Guest editor of Wiley - Eur J Org Chem., vol 2013(8) and the book Carbohydrate Mimics (1998); of Springer - Topics in Current Chemistry, vols 294, 295 in 2010; of DeGruyter - Pure and Applied Chemistry (vol 89(7) in2017 and vol 88(4) in2016); Ph.D. in Carbohydrate Chemistry (TU Graz, Austria); Expert in monosaccharide chemistry (deoxygenation, Wittig olefination, domino reactions, C-glycosylation, nucleoside synthesis, glycomedicinal chemistry), with more than 150 publications in the area, 15 book chapters and 10 granted patents.
Bjørn E. Christensen holds a Dr. philos. degree in biotechnology from NTNU - Norwegian University of Science and Technology, Norway, where he also had a career as research scientist until 2002 when he became a full professor. His research field is polysaccharide engineering and includes studies of macromolecular characterisation and structure-function relationships in among other alginates, chitosans, pectins, xanthan and ß-1,3-glucans. He has also been visiting scientist/professor at Montana State University, USA (1985), Osaka Prefecture University, Japan (2009), Cermav-CNRS Grenoble, France (2010) and University of Bordeaux, France (2016).
Full professor, former director of the Institute of Chemistry and head of the Department of Organic Chemistry of the University of Debrecen, Hungary. Serves as an editorial board member for Carbohydrate Research, and as guest editor for special issues of Carbohydrate Research, Mini-Reviews in Medicinal Chemsitry, Molecules, Topics in Heterocyclic Chemistry. Research interests include synthetic carbohydrate chemistry directed to C-glycosyl compounds, anomeric-spirocycles, glycals, exo-glycals and their derivatives; development of synthetic methodology involving radicals and carbenes; synthesis of glycosidase and glycogen phosphorylase inhibitors as potential antidiabetics, study of their structure-activity relationships; synthesis of glycomimetics and glycopeptidomimetics.
Roberto Adamo obtained his PhD in Pharmaceutical Science from the University of Catania (Italy) in 2003, with a thesis on the synthesis of biologically relevant inositols. He was post-doctoral fellow at the NIH in Bethesda (USA), under the supervision of Dr. P. Kovac, and then in the group of Prof. J. P. Kamerling at the Utrecht University (The Netherlands). In 2007 he joined Novartis Vaccines where he was later apoointed Head of the Carbohydrate Chemistry Laboratory, and Leader of the Conjugation & Synthesis Platform. Following the company acquisition by GSK he became Preclinical Representative Leader of the Conjugation Platform. His research interests focus on the synthesis of glycans, glycoconjugates and glyconanoparticles to be used for carbohydrate-based therapeutics. He has been recently appointed Conjugation Technology Platform Leader at GSK, covering chemical and glycoengineering approaches for glycoconjugate vaccines. He is associate editor in the Glycoconjugate Journal and Coordinator of the EU network Glycovax.