Upcoming Vaccine Technologies for Infectious Diseases
Vaccine Delivery platforms: This section covers various nanoparticle-based vaccine delivery platforms such as nanoparticles of biological (self-assembling proteins) and non-biological origin (inorganic and polymeric). The biological nanoparticles subsection overlaps with virus-like particles that has been separately addressed.
Virus-Like Particles: Virus-Like Particles are biological nanoparticles having size of around 20-100 nm. Due to the repetitive nature, viral capsid proteins have tendency to self-assemble. Lack of genetic material makes them non-replicative and hence safe vaccines. Therefore, VLPs are gaining a lot of attractions from vaccine development point of view.
Bacterial and fungal vaccines: This part discusses upcoming vaccines which can protect against multiple bacterial and fungal infections, toxoid vaccines, neutralizing antibodies and new technologies like carbohydrate-conjugate vaccines, surface antigen vaccines etc.
Synthetic vaccines: The segment of synthetic vaccines talks about the short, long and synthetic peptide vaccines against viral and bacterial diseases, innovative T cell stimulating immunogens and fusion proteins.
Viral vector-based vaccines: It covers genetically modified viral vectors which are engineered to make replication incompetent by deletion of essential genes or highly attenuated viral vectors that lack pathogenic genes.
Adjuvant technology: Unique lipid-based adjuvants, oil-in-water adjuvants, plant-derived adjuvants, synthetic and immune-cell-receptor based adjuvants as well as virosomes (derived from viral proteins) are reviewed here.
Vaccine synthesis, formulation and delivery platforms: This section partially overlaps with virus-based vaccine delivery platforms like virosomes, synthetic and modified-viral platforms, cell-free protein synthesis and gene delivery methods and proprietary cell lines used for vaccine production.
Table of Contents
1.2 Analysis Framework: Frost & Sullivan Core Value
1.3 Research Methodology: Five Steps Toward Success
1.4 Key Findings of Global Vaccine Technology Development
2.2 Technologies Transforming Next-generation Vaccines
3.2 Self-assembling Nanoparticles of Biological Origin
3.3 Polymeric and Inorganic Nanoparticles for Vaccine Delivery
4.2 Landscape of VLP-based Vaccines, Global, 2019
4.3 Influenza Shares A Major Portion of VLP-based Vaccines
4.4 Multiple Adaptations of VLP Technology for Vaccine Development
4.5 Plant Leaves Producing A Wide Variety of VLPs
5.2 Emerging Bacterial and Fungal Vaccines, Global, 2019
5.3 New Strategies for Bacterial and Fungal Vaccines
5.4 Novel Vaccines & Therapeutics for Emerging Infectious Diseases
5.5 Multi-protein Complex-based Bacterial Vaccines
5.6 Carbohydrates-based or Conjugate Vaccines
6.2 Peptides-based Vaccine Technologies
6.3 Genetically Modified Vaccines for HIV and Streptococci
7.2 Summary of Developing Viral Vector Vaccine Technology, Global, 2019
7.3 Diverse Replication-incompetent Viral Vaccines
7.4 Replication-incompetent Viruses with Nasal Spray Formulation
7.5 Live Attenuated Influenza Vaccines with Nasal Formulation
7.6 Viral Vector Vaccines for Serious Human Diseases
8.2 Oil-in-water Nanoemulsion and Saponin-based Adjuvants
8.3 Toll-like Receptor-based Adjuvants
9.2 Cell-free and Cell-based Vaccine Synthesis Platforms
9.3 Diverse Vaccine Formulation Technologies
9.4 Needle-less Solid Dose Vaccine Delivery Formulation and Device
9.5 Gold Nanoparticles and Applications in Vaccine Delivery
9.6 Nanopatch, Recombinant Protein and Lipid-based Carriers
10.2 Growth Opportunity 2: Vaccines for Vector Borne Viral Diseases
10.3 Growth Opportunity 3: Vaccine Delivery Technologies
10.4 Strategic Imperatives for Success and Growth