Drug Overview
Darzalex (daratumumab; Johnson & Johnson) targets the transmembrane glycoprotein CD38, which is highly expressed on malignant multiple myeloma cells, but expressed at low levels in other tissues.
By binding to this protein, Darzalex induces myeloma cell death by several different mechanisms including apoptosis and antibody- and complement-dependent cytotoxicity.
Darzalex (daratumumab; Johnson & Johnson) targets the transmembrane glycoprotein CD38, which is highly expressed on malignant multiple myeloma cells, but expressed at low levels in other tissues.
By binding to this protein, Darzalex induces myeloma cell death by several different mechanisms including apoptosis and antibody- and complement-dependent cytotoxicity.
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