Drug Overview
Xalkori (crizotinib; Pfizer/Merck KGaA) is a selective, adenosine triphosphate-competitive small molecule multi-kinase inhibitor of mesenchymal epithelial transition growth factor (c-Met or hepatocyte growth factor), ROS1, and anaplastic lymphoma kinase (ALK) tyrosine kinases, which are implicated in the progression of several cancers, including non-small cell lung cancer (NSCLC). Gene rearrangements result in fusion proteins with constitutive activation of the ALK kinase domain. In NSCLC, the most commonly identified fusion partner for ALK in these rearrangements is the 5'-end of the echinoderm microtubule-associated protein-like 4 gene (EML4). According to Pfizer, fusion of the EML4 gene to ALK (also known as an EML4-ALK translocation) has been reported in 3–5% of all NSCLC cases.
Xalkori (crizotinib; Pfizer/Merck KGaA) is a selective, adenosine triphosphate-competitive small molecule multi-kinase inhibitor of mesenchymal epithelial transition growth factor (c-Met or hepatocyte growth factor), ROS1, and anaplastic lymphoma kinase (ALK) tyrosine kinases, which are implicated in the progression of several cancers, including non-small cell lung cancer (NSCLC). Gene rearrangements result in fusion proteins with constitutive activation of the ALK kinase domain. In NSCLC, the most commonly identified fusion partner for ALK in these rearrangements is the 5'-end of the echinoderm microtubule-associated protein-like 4 gene (EML4). According to Pfizer, fusion of the EML4 gene to ALK (also known as an EML4-ALK translocation) has been reported in 3–5% of all NSCLC cases.
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OVERVIEW
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