Drug Overview
Abraxane (nab-paclitaxel; Celgene/Taiho) is an albumin-bound formulation of paclitaxel, an anti microtubule taxane that interferes with the growth of tumors by inhibiting mitosis during metaphase. Standard forms of paclitaxel require solvents such as Cremophor (polyoxyethylated castor oil) to allow for intravenous administration. Such lipid-based solvents can lead to potentially severe hypersensitivity reactions, and may require the premedication of patients with steroids prior to each treatment. Abraxane’s novel albumin-bound formulation makes it readily soluble in saline, and eliminates the need for toxic solvents. Preclinical studies of Abraxane have also demonstrated increased paclitaxel transport across endothelial cells and greater antitumor activity compared to standard paclitaxel.
Abraxane (nab-paclitaxel; Celgene/Taiho) is an albumin-bound formulation of paclitaxel, an anti microtubule taxane that interferes with the growth of tumors by inhibiting mitosis during metaphase. Standard forms of paclitaxel require solvents such as Cremophor (polyoxyethylated castor oil) to allow for intravenous administration. Such lipid-based solvents can lead to potentially severe hypersensitivity reactions, and may require the premedication of patients with steroids prior to each treatment. Abraxane’s novel albumin-bound formulation makes it readily soluble in saline, and eliminates the need for toxic solvents. Preclinical studies of Abraxane have also demonstrated increased paclitaxel transport across endothelial cells and greater antitumor activity compared to standard paclitaxel.
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