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Simponi

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    Report

  • 55 Pages
  • May 2018
  • Region: Global
  • Citeline
  • ID: 4775241
Drug Overview
Simponi (golimumab; Johnson & Johnson/Merck & Co/Mitsubishi Tanabe) is a second-generation TNF inhibitor following Johnson & Johnson's Remicade (infliximab).

It is a fully human monoclonal antibody that inhibits the TNF-alpha receptor and is indicated for the treatment of psoriatic arthritis (PsA), rheumatoid arthritis (RA), polyarticular juvenile idiopathic arthritis, ulcerative colitis, and axial spondyloarthritis.

In the US, both the subcutaneous and intravenous formulations of Simponi are licensed for use in RA, PsA, and ankylosing spondylitis. Simponi IV is marketed under the brand name Simponi Aria.

Table of Contents

OVERVIEW
Drug Overview
Product Profiles
Simponi : Axial spondyloarthritis (axSpA)
Simponi : Rheumatoid arthritis (RA)
Simponi : Psoriatic arthritis (PsA)
Simponi : Ulcerative colitis
LIST OF FIGURES
Figure 1: Simponi for axial spondyloarthritis – SWOT analysis
Figure 2: The authors drug assessment summary of Simponi in axial spondyloarthritis
Figure 3: The authors drug assessment summary of Simponi in axial spondyloarthritis
Figure 4: Simponi and Simponi Aria sales for axial spondyloarthritis across the US, Japan, and five major EU markets, by country, 2016–25
Figure 5: Simponi for rheumatoid arthritis – SWOT analysis
Figure 6: The authors drug assessment summary of Simponi in rheumatoid arthritis
Figure 7: The authors drug assessment summary of Simponi in rheumatoid arthritis
Figure 8: Simponi for psoriatic arthritis – SWOT analysis
Figure 9: The authors drug assessment summary of Simponi for psoriatic arthritis
Figure 10: The authors drug assessment summary of Simponi for psoriatic arthritis
Figure 11: Simponi for ulcerative colitis – SWOT analysis
Figure 12: The authors drug assessment summary of Simponi for ulcerative colitis
Figure 13: The authors drug assessment summary of Simponi for ulcerative colitis
LIST OF TABLES
Table 1: Simponi drug profile
Table 2: Simponi pivotal trial data in axial spondyloarthritis
Table 3: Simponi Aria pivotal trial data in axial spondyloarthritis
Table 4: Simponi and Simponi Aria sales for axial spondyloarthritis across the US, Japan, and five major EU markets, by country ($m), 2016–25
Table 5: Simponi drug profile
Table 6: Simponi pivotal trial data in rheumatoid arthritis
Table 7: Simponi Aria pivotal trial data in rheumatoid arthritis
Table 8: Overview of the five-year efficacy and safety data for Simponi pivotal Phase III trials
Table 9: Simponi drug profile
Table 10: Simponi pivotal trial data in psoriatic arthritis
Table 11: Simponi Aria pivotal trial data in psoriatic arthritis
Table 12: Simponi drug profile
Table 13: Simponi pivotal trial data in ulcerative colitis