Drug Overview
Developed by Genentech, Pulmozyme is a recombinant form of human deoxyribonuclease I produced by genetically engineered Chinese hamster ovary cells.
In patients with cystic fibrosis, high concentrations of extracellular DNA are commonly found in the sputum as a result of the body’s innate response to respiratory infections.
This increases the viscoelasticity of the mucus, reducing pulmonary function and increasing risk of further infection. Pulmozyme hydrolyzes DNA, reducing the viscoelasticity of sputum and encouraging its clearance.
Developed by Genentech, Pulmozyme is a recombinant form of human deoxyribonuclease I produced by genetically engineered Chinese hamster ovary cells.
In patients with cystic fibrosis, high concentrations of extracellular DNA are commonly found in the sputum as a result of the body’s innate response to respiratory infections.
This increases the viscoelasticity of the mucus, reducing pulmonary function and increasing risk of further infection. Pulmozyme hydrolyzes DNA, reducing the viscoelasticity of sputum and encouraging its clearance.
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