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  • 13 Pages
  • July 2018
  • Region: Global
  • Pharma Intelligence
  • ID: 4775301
Drug Overview
Aggrenox (Boehringer Ingelheim/GlaxoSmithKline/Bayer) capsules contain two active ingredients, acetylsalicylic acid and extend-release dipyridamole. Each active ingredient inhibits platelet aggregation through a distinct pathway. Aspirin works by irreversibly inhibiting the cyclooxygenase-1 and cyclooxygenase-2 enzymes, which are responsible for the synthesis of prostaglandins and thromboxanes.

Prostaglandins and thromboxanes trigger the platelet aggregation needed for clot formation to occur. By inhibiting cyclooxygenase-1 and cyclooxygenase-2, Aspirin decreases the number of prostaglandins and thromboxanes present, resulting in a reduction in platelet aggregation. By limiting platelet aggregation, Aspirin inhibits blood clot formation.

Table of Contents

Drug Overview
Product Profiles
Aggrenox: Stroke
Figure 1: Aggrenox for ischemic stroke – SWOT analysis
Figure 2: The authors drug assessment summary of Aggrenox for ischemic stroke
Figure 3: The authors drug assessment summary of Aggrenox for ischemic stroke
Table 1: Aggrenox drug profile
Table 2: Aggrenox pivotal trial data in ischemic stroke
Table 3: Aggrenox late-phase trial data in ischemic stroke