Market Spotlight: Psoriatic Arthritis

This Market Spotlight report covers the psoriatic arthritis market, comprising key marketed and pipeline drugs, recent events and analyst opinion, clinical trials, upcoming and regulatory events, probability of success, patent information, epidemiology information, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.

Key Takeaways

• The approved drugs in the psoriatic arthritis space focus on a wide variety of targets. The majority of approved drugs are administered via the subcutaneous route, with the remainder being intravenous, intramuscular, oral, and topical formulations.
• The majority of industry-sponsored drugs in active clinical development for psoriatic arthritis are in Phase III, with only one drug in the NDA/BLA stage.
• Therapies in development for psoriatic arthritis focus on targets such as TNF-alpha, IL-23, JAK/STAT, IL-17, selectins, and tyrosine kinase 2. These drugs are administered via the oral, subcutaneous, and intravenous routes.
• High-impact upcoming events for drugs in the psoriatic arthritis space comprise topline Phase III trial results for bimekizumab, topline Phase II trial results for BMS-986165, and an estimated PDUFA date as well as expected CHMP supplemental filing results for Tremfya.
• The overall likelihood of approval of a Phase I psoriasis asset is 13%, and the average probability a drug advances from Phase III is 75%. Drugs, on average, take 7.7 years from Phase I to approval, compared to 9.0 years in the overall autoimmune/immunology space.
• The distribution of clinical trials across Phase I–IV indicates that the majority of trials for psoriatic arthritis have been in the late phases of development, with 79% of trials in Phase III–IV, and only 21% in Phase I–II.
• The US leads in terms of the number of psoriatic arthritis clinical trials globally, while Germany leads the major European markets.
• Clinical trial activity in the psoriatic arthritis space is dominated by completed trials. AbbVie has the highest number of completed clinical trials for psoriatic arthritis, with 31 trials.
• AbbVie leads industry sponsors with the highest overall number of clinical trials for psoriatic arthritis, followed by Bristol Myers Squibb.