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Filgotinib

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    Report

  • 36 Pages
  • July 2018
  • Region: Global
  • Citeline
  • ID: 4775393
Drug Overview
Filgotinib (Galapagos/Gilead) is an orally available Janus kinase (JAK)-1 inhibitor. The drug inhibits the JAK-1 receptor required for signal transduction upon binding of cytokines at the cell surface. This, in turn, blocks the JAK/STAT signaling pathway required to activate gene expression of various immune cells. Filgotinib is in late-phase development in Crohn’s disease, ulcerative colitis, and rheumatoid arthritis.

Table of Contents

OVERVIEW
Drug Overview
Product Profiles
filgotinib: Rheumatoid arthritis (RA)
filgotinib: Ulcerative colitis
filgotinib: Crohn's disease
LIST OF FIGURES
Figure 1: Filgotinib for rheumatoid arthritis – SWOT analysis
Figure 2: The authors drug assessment summary of filgotinib in rheumatoid arthritis
Figure 3: The authors drug assessment summary of filgotinib in rheumatoid arthritis
Figure 4: Filgotinib for ulcerative colitis – SWOT analysis
Figure 5: The authors drug assessment summary of filgotinib for ulcerative colitis
Figure 6: The authors drug assessment summary of filgotinib for ulcerative colitis
Figure 7: Filgotinib for Crohn’s disease – SWOT analysis
Figure 8: The authors drug assessment summary of filgotinib in Crohn’s disease
Figure 9: The authors drug assessment summary of filgotinib in Crohn’s disease
Figure 10: Filgotinib sales for Crohn’s disease across the US, Japan, and five major EU markets, by country, 2016–25
LIST OF TABLES
Table 1: Filgotinib drug profile
Table 2: Filgotinib Phase III trials in rheumatoid arthritis
Table 3: Primary endpoint for filgotinib at week 12 in the Phase IIb DARWIN 2 trial
Table 4: Efficacy responses with filgotinib after 12 and 24 weeks of treatment in the DARWIN 1 trial (%)
Table 5: Filgotinib drug profile
Table 6: Filgotinib Phase III trials in ulcerative colitis
Table 7: Filgotinib drug profile
Table 8: Ongoing pivotal Phase III trials of filgotinib in Crohn’s disease
Table 9: Phase II trial data of filgotinib in Crohn’s disease
Table 10: Filgotinib sales for Crohn’s disease across the US, Japan, and five major EU markets, by country ($m), 2016–25