Drug Overview
Filgotinib (Galapagos/Gilead) is an orally available Janus kinase (JAK)-1 inhibitor. The drug inhibits the JAK-1 receptor required for signal transduction upon binding of cytokines at the cell surface. This, in turn, blocks the JAK/STAT signaling pathway required to activate gene expression of various immune cells. Filgotinib is in late-phase development in Crohn’s disease, ulcerative colitis, and rheumatoid arthritis.
Filgotinib (Galapagos/Gilead) is an orally available Janus kinase (JAK)-1 inhibitor. The drug inhibits the JAK-1 receptor required for signal transduction upon binding of cytokines at the cell surface. This, in turn, blocks the JAK/STAT signaling pathway required to activate gene expression of various immune cells. Filgotinib is in late-phase development in Crohn’s disease, ulcerative colitis, and rheumatoid arthritis.
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