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Natural Killer Cell Therapies: Pipeline Review

  • ID: 4806531
  • Report
  • Region: Global
  • 80 Pages
  • Roots Analysis
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FEATURED COMPANIES

  • Anhui Provincial Hospital
  • Duke University
  • Hangzhou Cancer Hospital
  • Multimmune
  • Sabz Biomedicals
  • University of Arkansas
  • MORE

Natural killer (NK) cells, or killer (K) cells, represent an important subset of cellular mediators of the innate immune system. These cells are known to be instrumental in containing viral infections and regulating tumor development, while the adaptive immune system generates an antigen-specific response. Technically, they are classified as group I innate lymphocytes. Although they share a common progenitor, NK cells are very different from B-lymphocytes and T-lymphocytes and do not require specific antigen-based activation in order to function. The cytotoxic effects of these cells are mediated using perforin and granzymes, which is somewhat similar to the mode of action of cytotoxic T cells. Additionally, studies have demonstrated that NK cells can also secrete certain cytokines and chemokines, such as IFNγ and TNFα, through which they can recruit other immune components to augment and sustain an immune response. For instance, IFNγ secreted by NK cells has been shown to be involved in T-helper (TH1) cell-based immune response, and the activation of certain antigen-presenting cells and macrophages. Alternatively, NK cells have been shown to respond to certain types of interferons and macrophage-derived cytokines.

Several studies have demonstrated the various benefits of NK cells as a therapeutic tool. Currently, these cells are being evaluated across multiple clinical trials to treat various types of cancer and infectious diseases. Further, the genetic modification of NK cells has demonstrated additional benefits, and many companies are also working on developing allogeneic product candidates that can be used as off-the-shelf therapies.

Scope of the Report

The “Natural Killer Cell Therapies: Pipeline Review” report features an extensive study of the current market landscape and clinical research scenario related to all NK cell-based products/product candidates. The information in this report has been presented in the form of interactive dashboards, aiming to provide a comprehensive overview of the ongoing activity in this domain, and offering insights on a number of important parameters, including:

  • An analysis of the contemporary developer landscape, providing information on key innovator companies and their respective NK cell therapies, current (highest) phase of development, source of NK cells (autologous and allogenic), target disease indication (hematological malignancies, solid tumors and others), type of therapy (monotherapy and combination therapy), route of administration and other relevant details (if available).
  • Analysis of both completed and active clinical trials, initiated from January 2009, featuring details on (primary) developer company (year of establishment, location of headquarters, and company size), type of developer (industry and non-industry), name of therapy, source of NK cells (autologous and allogenic), and other trial-related details (collaborating sponsors, trial title, study objectives, location of trial, current status, availability of results, target therapeutic indication, study type, current / anticipated enrolment, study start / end date and key outcomes / results).
  • Analysis of terminated clinical trials, highlighting the developer company, type of developer (industry and non-industry), name of therapy, source of NK cells (autologous and allogenic), other trial-related details (collaborating sponsors, trial title, study objectives, target therapeutic indication and study type) and reason for termination.

All information has been sourced and analyzed from company websites, press releases, reliable clinical trial data repositories (such as clinicaltrials.gov), and other publicly available information platforms.

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FEATURED COMPANIES

  • Anhui Provincial Hospital
  • Duke University
  • Hangzhou Cancer Hospital
  • Multimmune
  • Sabz Biomedicals
  • University of Arkansas
  • MORE

1. Introduction and Scope

2. Developer Landscape
2A. Developer Landscape: Analysis by Location of Headquarters
2B. Developer Landscape: Analysis by Phase of Development
2C. Developer Landscape: Analysis by Target Disease Indication
2D. Developer Landscape: Analysis by Source of NK Cells
2E. Developer Landscape: Analysis by Type of Therapy
2F. Developer Landscape: Analysis by Route to Administration
2G. Developer Landscape: Analysis by Year of Establishment (Industry Players)
2H. Developer Landscape: Analysis by Company Size (Industry Players)

3. Completed and Active Trials
3A. Clinical Trial Analysis: Analysis by Current Trial Status
3B. Clinical Trial Analysis: Analysis by Phase of Development
3C. Clinical Trial Analysis: Analysis by Availability of Results
3D. Clinical Trial Analysis: Analysis by Target Disease Indication
3E. Clinical Trial Analysis: Analysis by Source of NK Cells
3F. Clinical Trial Analysis: Analysis by Type of Therapy
3G. Clinical Trial Analysis: Analysis by Study Type
3H. Clinical Trial Analysis: Analysis of Enrolled Patient Population
3I. Clinical Trial Analysis: Analysis by Study Start / End Dates
3J. Geographical Location of Primary Sponsor
3K. Geographical Location of Completed / Active Trials

4. Terminated Trials
4A. Terminated Trials: Analysis by Reason for Termination
4B. Terminated Trials: Analysis by Phase of Development
4C. Terminated Trials: Analysis by Target Disease Indication
4D. Terminated Trials: Analysis by Source of NK Cells
4E. Terminated Trials: Analysis by Type of Therapy
4F. Terminated Trials: Analysis by Study Type

5. Appendix I: Dataset 1: Developer Landscape

6. Appendix II: Dataset 2: Completed / Active Clinical Research Trials

7. Appendix III: Dataset 3: Terminated Clinical Research Trials

8. Appendix IV: Dataset 4: Clinical Research, 2009-2019

9. Abbreviations

10. Sources and Bibliography

List of Figures

Figure 2.1. Developer Landscape: Distribution by Location of Headquarters
Figure 2.2. Developer Landscape: Distribution by Phase of Development
Figure 2.3. Developer Landscape: Distribution by Target Disease Indication
Figure 2.4. Developer Landscape: Distribution by Source of NK Cells
Figure 2.5. Developer Landscape: Distribution by Type of Therapy
Figure 2.6. Developer Landscape: Distribution by Route to Administration
Figure 2.7. Developer Landscape: Distribution by Year of Establishment (Industry Players)
Figure 2.8. Developer Landscape: Distribution by Company Size (Industry Players)
Figure 3.1. Clinical Trial Analysis: Distribution by Current Trial Status
Figure 3.2. Clinical Trial Analysis: Distribution by Phase of Development
Figure 3.3. Clinical Trial Analysis: Distribution by Availability of Results
Figure 3.4. Clinical Trial Analysis: Distribution by Target Disease Indication
Figure 3.5. Clinical Trial Analysis: Distribution by Source of NK Cells
Figure 3.6. Clinical Trial Analysis: Distribution by Type of Therapy
Figure 3.7. Clinical Trial Analysis: Distribution by Study Type
Figure 3.7. Clinical Trial Analysis: Distribution of Enrolled Patient Population
Figure 3.7. Clinical Trial Analysis: Distribution by Study Start / End Dates
Figure 3.8. Geographical Location of Primary Sponsor
Figure 3.9. Geographical Location of Completed / Active Trials
Figure 4.1. Terminated Trials: Distribution by Reason for Termination
Figure 4.2. Terminated Trials: Distribution by Phase of Development
Figure 4.3. Terminated Trials: Distribution by Target Disease Indication
Figure 4.4. Terminated Trials: Distribution by Source of NK Cells
Figure 4.5. Terminated Trials: Distribution by Type of Therapy
Figure 4.6. Terminated Trials: Distribution by Study Type

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  • Allife Medical Science and Technology
  • Anhui Provincial Hospital
  • Asan Medical Center
  • Baylor College of Medicine
  • Capital Medical University
  • Case Comprehensive Cancer Center
  • Catholic University of Korea
  • Cell Medica
  • CellProtect Nordic Pharmaceuticals
  • Celularity
  • Chinese PLA General Hospital
  • CiMass
  • Cyto-Sen Therapeutics
  • Cytovac
  • Dresden University of Technology
  • Duke University
  • Fate Therapeutics
  • First Hospital of Jilin University
  • Fortress Biotech
  • Fuda Cancer Hospital
  • Gamida Cell
  • GC PharmaGreen Cross Corporation
  • Glycostem Therapeutics
  • Gregorio Marañón Hospital
  • Gruppo Italiano Malattie EMatologiche dell'Adulto
  • Guangdong Provincial Hospital of Traditional Chinese Medicine
  • Guangzhou Medical University
  • Hangzhou Cancer Hospital
  • Harbin Medical University
  • Henan Cancer Hospital
  • Hospital of Clinics of Porto Alegre
  • Hospital Universitario La PazHospital La Paz
  • iCell Gene Therapeutics
  • Italian Group Hematological Diseases of the Adult
  • Italian Sarcoma Group
  • Ivy Life Sciences
  • M.D. Anderson Cancer Center
  • Mayo Clinic
  • Medical College of Wisconsin
  • Memorial Sloan Kettering Cancer Center
  • Multimmune
  • NantKwest
  • National Cancer Institute
  • National Defense Medical Center
  • National University Hospital
  • Niño Jesús University Children's HospitalHospital Niño Jesus
  • Nkarta Therapeutics
  • Nohla Therapeutics
  • Paoli-Calmettes Institute
  • PersonGen BioMedicineTherapeutics
  • Pope John XXIII HospitalA.O. Ospedale Papa Giovanni XXIII
  • Public Assistance - Hospitals of Paris
  • Radboud University
  • Sabz Biomedicals
  • Samsung Medical Center
  • Seoul National University Hospital
  • Shanghai Houchao Biotechnology
  • Shanghai iCELL Biotechnology
  • Shanghai Public Health Clinical Center
  • Shenzhen Hornetcorn Bio-technology Company
  • Shenzhen Second People's Hospital
  • SMT Bio
  • Southwest Medical UniversityHospital, China
  • St. Jude Children's Research Hospital
  • Stanford University
  • Sun Yat-sSen University
  • Surface Oncology
  • Tanta University
  • The Catholic University of Korea
  • The First People's Hospital of Changzhou
  • University Hospital of, Basel
  • University Hospital ofin Besançon
  • University of Arkansas
  • University of Minnesota
  • University of Wisconsin
  • Washington University School of Medicine
  • Xuanwu Hospital
  • Xuzhou Medical University
  • Yonsei University
  • Zumutor Biologics
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