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Pan-genomics: Applications, Challenges, and Future Prospects

  • Book
  • March 2020
  • Elsevier Science and Technology
  • ID: 4806637

Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches,” brings the main concepts and current approaches on pan-genomics research; the second, "case studies in pan-genomics,” thoroughly discusses twelve case, and the last, "current approaches and future prospects in pan-multiomics”, encompasses the developments on omics studies to be applied on bacteria related studies.

This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health.

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Table of Contents

1. Overview, applications, and future perspectives of Pan-genomics 2. Bioinformatics approaches applied in Pan-genomics and their challenges 3. Evolutionary pan-genomics and applications 4. Insights into old and new enemies: Pan-genomics of Corynebacterium diphtheriae and Corynebacterium ulcerans 5. Pan-genomics of Veterinary pathogens: Corynebacterium psedotuberculosis 6. Pan-genomics of Plant pathogens and its applications 7. Pan-genomics food pathogens and its applications 8. Pan-genomics of aquatic animal pathogens and its applications 9. Pan-genomics of model bacteria and their outcomes 10. Pan-genomics of multi drug-resistant human pathogenic bacteria and their resistome 11. Pan-genomics of Virus and its applications 12. Pan-genomics of Fungi and its applications 13. Pan-genomics of Algae and applications 14. Pan-genomics of Plants and its applications 15. Pan-cancer analysis and applications 16. Reverse vaccinology and drug target identification through Pan-genomics 17. Pan-metagenomics and its applications 18. Pan-transcriptomics and its applications 19. Pan-proteomics and its applications 20. Pan-metabolomics and its applications 21. Pan-interactomics and its applications


Debmalya Barh Principal Scientist, Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India. Debmalya Barh, PhD, holds Master's and PhD's degree on Biotechnology and Post-Doc on Bioinformatics. He is honorary Principal Scientist at Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology, a global platform of multidisciplinary research and advocacy. He has experience with both academic and industrial research and has more than 12 years on bioinformatics and personalized diagnostic/medicine industry experience, with focus on translating academic research into high value commercial products. He has published more than 150 articles in reputed international journals and has edited 15 cutting-edge biotechnology related reference books. He has also co-authored 30+ book chapters. Due to his significant contribution in the field, he has been recognized by Who's Who in the World and Limca Book of Records. Siomar C. Soares Professor, Department of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triangulo Mineiro (UFTM), Brazil. Dr Soares holds a degree in Biomedicine, with special training in Bioinformatics, Master's Degree and PhD in Genetics by Federal University of Minas Gerais - UFMG, the latter with one year of study at the Center for Biotechnology (CeBiTec), Universität Bielefeld. He holds a Post-doctorate in Bioinformatics by UFMG. He was Senior Researcher Bioinformatics at the Central Official Laboratory of the Brazilian Ministry of Fisheries and Aquaculture (2014-2015). He is currently Professor at Federal University of the Triângulo Mineiro (UFTM) since 2015, Secretary of the Southeastern regional of the Brazilian Society of Genetics (2017-current), Substitute Coordinator of the undergraduate course in Biomedicine at UFTM (2017-current) and Substitute Research and Technology Development Coordinator of UFTM (2017-current). His research interests are molecular genetics, genomic sequencing and comparative genomics of microorganisms, focusing on pan-genomics, genomic plasticity in the identification of islands of pathogenicity and virulence factors, phylogenomics, molecular epidemiology, reverse vaccination and software development. Sandeep Tiwari Post-doctoral Research Fellow, Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais. Dr. Tiwari obtained his BSc from Deen Dayal Upadhyaya Gorakhpur University, MSc in Bioinformatics from Devi Ahilya University, and PhD in Bioinformatics from Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Brazil. He is Guest Associate Editorial Board of Frontier in Genetics and frequently serves as an external reviewer for PeerJ and Frontiers. His main areas of expertise are molecular genetics, genomic sequencing and comparative genomics of microorganisms, with a focus on pan-genomics, genomic plasticity in the identification of pathogenicity islands and virulence factors for drug discovery, phylogenomic, molecular epidemiology, reverse vaccinology, and immunoinformatic. Vasco Ariston De Car Azevedo Professor, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Brazil. Vasco Azevedo is a full professor, CNPq researcher 1A, member of the Brazilian Academy of Sciences, Commander of the Order of Scientific Merit of the MCTI, of the Genetics advisory committee and the public policy working group on Biotechnology and Genetic resources of COBRG / CNPq, coordinator of the Associated International Laboratory Bact-infl from INRA and UFMG, and vice-president of the Brazilian Association of Bioinformatics and Computational Biology (AB3C). He holds a degree in Veterinary Medicine from the School of Veterinary Medicine of the Federal University of Bahia (1986), a master's degree (1989), and a doctorate (1993) in Genetics of Microorganisms from the Institut National Agronomique Paris Grignon. Post-doctorate from the Department of Microbiology, School of Medicine, University of Pennsylvania (the USA, 1994). Professor at the Institute of Biomedical Sciences of the University of São Paulo (2004) and Ph.D. in Bioinformatics at UFMG (2017). He has experience in Genetics and Bioinformatics, emphasizing Molecular and Microorganism Genetics, acting mainly on the following topics: Genomics; transcriptomics; proteomics, metabolomics; Functional analysis of genes; Virulence and pathogenicity study, Molecular Biotechnology and Biosafety. He works on vaccine development, diagnostics, and the development of next-generation probiotics.