Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment.
Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood.
- Features two new sections on serotonin systems interactions and serotonin in neurological disorders
- Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior
- Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes
- Covers the interactions between serotonin, melatonin and kynurenine pathways
Section 1: Functional anatomy of the serotonergic system 1.1 Evolution of serotonin: sunlight to suicide 1.2 From B1 to B9: a guide through hindbrain serotonin neurons with additional views from multidimensional characterization 1.3 Serotonin System Function, Organization and Feedback 1.4 Ultrastructure of the serotonin innervation in mammalian central nervous system 1.5 Classification and Signaling Characteristics of 5-HT Receptors: Towards the Concept of 5-HT Receptosomes 1.6 Distribution of 5-HT receptors in the central nervous system: An update 1.7 The serotonin2B receptor and neurochemical regulation in the brain 1.8 Electrochemical Detection of Serotonin Release in Rodents 1.9 Molecular neuroimaging of the serotonergic system with Positron Emission Tomography
Section 2: The neurophysiology of serotonin 2.1 Serotonergic control of excitability: from neuron to networks 2.2 Structure and function of serotonin GPCR heteromers 2.3 Tryptophan hydroxylase and serotonin synthesis regulation 2.4 Serotonylation and neuronal function 2.5 The effects of serotonin degradation on psychopathology: Role of monoamine oxidase 2.6 Cellular effects of serotonin in the CNS 2.7 Serotonin
lipid interactions and their role in behavior 2.8 Serotonin
Pain Modulation 2.9 Serotonin regulation of striatal function 2.10 Serotonergic regulation of hippocampal rhythmical activity 2.11 The loudness dependence of auditory evoked potentials as an electrophysiological marker of central serotonergic neurotransmission: implications for clinical psychiatry and psychopharmacotherapy
Section 3: Serotonin and systemic control 3.1 5-HT neurons and central CO2 chemoreception 3.2 Serotonin: a forgotten signal from the blood
Section 4: Serotonin and behavioural control 4.1 Serotonin and development 4.2 Roles of serotonin in the fetal brain 4.3 Serotonin and sensory processing 4.4 Serotonin and basal sensory-motor control 4.5 Role of the serotonergic system in appetite and ingestion control 4.6 Serotonin in eating behavior 4.7 Serotonin and the neurobiology of anxious states 4.8 Dorsal raphe serotonergic neurons regulate behavior on multiple timescales 4.9 The role of central serotonin in impulsivity, compulsivity and decision-making: Comparative studies in experimental animals and humans 4.10 The role of serotonin in learning and memory: a rich pallet of experimental studies 4.11 The role of serotonin in performance monitoring and cognitive control 4.12 Serotonin and 5-HT2B receptors in microglia control of behavior 4.13 The serotonin-free brain: behavioural consequences of Tph2 deficiency in animal models
Section 5: Serotonin in psychiatric disorders 5.1 Serotonin in panic and anxiety disorders 5.2 Serotonin and aggression
An update 5.3 Revisiting the Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression 5.4 Serotonin and schizophrenia 5.5 Serotonin neurobiology in cocaine use disorder 5.6 The role of serotonin in alcohol use and abuse 5.7 The role of serotonin in nicotine abuse and addiction 5.8 Serotonin and serotonin receptors in hallucinogen action 5.9 The serotonergic system in obsessive compulsive disorder 5.10 Peripheral and central serotonin in the regulation of glucose metabolism 5.11 The role of serotonin in cortical development: implications for Autism Spectrum Disorder 5.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions 5.13 Functional pharmacogenetics of serotonin receptors in psychiatric drug action 5.14 Classic psychedelics as therapeutics for psychiatric disorders
Section 6: Serotonin in neurological disorders 6.1 Serotonin in Parkinson's disease 6.2 Serotonin in seizures and epilepsy: a neurodevelopmental perspective 6.3 Serotonin and stroke