Toxicology Cases for the Clinical and Forensic Laboratory brings together carefully selected case studies to teach important principles relating to drug and toxin exposures. Each case study includes contemporary clinical and forensic toxicologist studies that include a comprehensive analytical and clinical approach to patient management and address overdoses from designer drugs, to NSAIDS, to opioids, to stimulants. These cases present a comprehensive, analytical and clinical approach to managing a drug overdose. This is a must-have reference for clinical and forensic laboratory scientists, along with toxicology and pathology residents who need to know aspects of both.
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Table of Contents
SECTION I Basic Principles 1. An Introduction to Clinical and Forensic Toxicology 2. Pharmacokinetics and Pharmacodynamics 3. Laboratory Methods in Toxicology 4. Management of an Overdose Patient 5. Alcohols: Volatiles and Glycols
SECTION II Overview and Case Studies 6. Analgesics and Anti-inflammatory Drugs 7. Antibiotics 8. Antidepressants and Antipsychotics 9. Anticonvulsants 10. Antineoplastic Drugs 11. Cannabinoids 12. Cardiotoxicity 13. CNS Depressants: Benzodiazepines and Barbiturates 14. CNS Stimulants 15. Designer Drugs 16. Hallucinogens and Psychedelics 17. Immunosuppressive Drugs 18. Opioids 19.�Toxic Herbals and Plants in U.S.� 20. Toxic Gases 21.�Toxic Metals� 22. Venoms and Pesticides 23. Case Studies on Other Drugs
AuthorsHema Ketha PhD, NRCC, Technical Director, Toxicology and Mass Spectrometry, LabCorp, Burlington, NC. Dr. Hema Ketha completed her post-doctoral research training at the Mayo Clinic in Rochester, MN focusing on areas exploring the role of vitamin D physiology in bone and kidney diseases, protein purification and protein interactions, mouse model studies of bone disease and development, validation and clinical implementation of liquid chromatography with tandem mass spectrometry (LC-MS/MS) analytical methods for vitamin D metabolic profiling. Then she pursued post-doctoral clinical training in clinical chemistry at the Mayo Clinic before joining the Department of Pathology at the University of Michigan.
She is currently a Technical Director, Toxicology and Mass Spectrometry, LabCorp, Burlington, NC. Her research interests are in clinical endocrinology, toxicology and clinical LC-MS/MS. She has won several awards from professional organizations including the AACC and ACLPS for her work in the areas of clinical chemistry and clinical mass spectrometry. She has research interests in areas of clinical endocrinology, toxicology and clinical LC-MS/MS. Additionally, she works on evaluating various immunoassays for current send-out esoteric analytes that can be validated and implemented at Michigan's clinical laboratory. She has authored peer-reviewed publications and won several awards from professional organizations including the AACC and ACLPS for her work in the areas of clinical chemistry and clinical mass spectrometry. Uttam Garg Garg Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO, United States; University of Missouri School of Medicine, Kansas City, MO, United States. Dr. Uttam Garg has published over 150 research papers, review articles, and book chapters in the area of clinical biochemistry, therapeutic drug monitoring and toxicology, and Co-Edited a book on Clinical Applications of Mass Spectrometry. His research interests include methods development in clinical laboratory diagnosis. His research interests include clinical method development on a variety of diagnostic platforms including mass spectrometry. He received his Ph.D. in Experimental Medicine from the Postgraduate Institute of Medical Education and Research in India. He received his postdoctoral training in Pharmacology at and Clinical Chemistry at New York Medical College and University of Minnesota Medical School respectively. Before joining his current position, he served as faculty at the NYU Medical Center and the University of Minnesota Medical School.