Nanomaterials in Clinical Medicine: Case Studies in Nanomedicines focuses on the nanomaterials that can be formulated as drug delivery vehicles, such as liposomes, micelles, nanoemulsions and nanogels. Their physicochemical, morphological, thermo-dynamical and nanotoxicological properties are analyzed with respect to the design and development of drug delivery nanosystems for the encapsulation of an active pharmaceutical ingredient and its controlled release. Each chapter covers basic properties, the nanosystem (e.g., liposomes), the added value in drug delivery and targeting, and future perspectives. Case studies and examples of how nanomaterials are being used in clinical medicine, including marketed liposomal medicines and medical utility and regimens are also included.
Particular attention is given to new nanocarriers, such as elastic liposomes, lipid polymeric hybrid nanoparticles, organogel, nanofibers carbon nanomaterials, quantum dots and inorganic nanoparticles. This book is an important information source for those wanting to increase their understanding of what major nanomaterials are being used to create more effective drug delivery systems.
- Summarizes the major nanomaterials used in clinical medicine, explaining how their properties make them suitable for this purpose
- Explains how nanomaterials are used to create increasingly efficient drug delivery vehicles
- Includes real-life examples, demonstrating how nanomaterials are being used in medical practice
1. Solid lipid nanoparticles in dermaceuticals 2. Cyclodextrin-based drug-delivery systems 3. Lipid vesicles for (trans)dermal administration 4. Stimuli-responsive nanocarriers for drug delivery 5. Biodegradable nanomaterials 6. Modulating the immune response with liposomal delivery 7. Recent advances in solid lipid nanoparticles formulation and clinical applications 8. Biopolymers, liposomes, and nanofibers as modified peroral drug release formulants 9. Grafted polymethacrylate nanocarriers in drug delivery
Costas Demetzos is Professor, Pharmaceutical Nanotechnology and Director in the Laboratory of Pharmaceutical Technology, Department of Pharmacy at the National and Kapodistrian University of Athens, Greece. His research focuses in the area of pharmaceutical nanotechnology.
Natassa Pippa is Pharmacist in the Laboratory of Pharmaceutical Nanotechnology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece. Her research focuses in the area of pharmaceutical nanotechnology, specifically in the areas of hydrogels, nanoemulsions and liposomes.