Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care provides a well-focused and comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, both in-vitro and in-vivo. The book briefly describes the advancement in cancer biomarker research relating to cancer diagnostics, covering fundamental aspects of various techniques, especially transduction methodologies, such as electrochemical, optical, magnetic, etc. In addition, it describes approaches on how to make options cost-effective, scalable for clinical application, and user-friendly. Advancements in technology related to device miniaturization, performance improvement and point-of-care applications round out discussions.
Final sections cover future challenges, the prospects of various techniques, and how the introduction of nanotechnology in cancer management in a personalized manner is useful.
- Includes smart sensing materials such as smart electro-active nanomaterials, sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical system, and device integration and interfacing for point-of-care applications
- Describes each component involved in the development of an efficient cancer diagnostics system
- Focuses on fundamental and applied concepts of the technologies, along with the related mechanisms proposed for diagnostics of cancer
- Enhances fundamental understandings of the concepts and development of nanotechnology based analytical tools and novel techniques for early stage cancer diagnostics and management
1. Introduction: Background, diagnostics, cancer biomarkers, state-of-art 2. Electrochemical Detection: CV/DPV/Impedance 3. Fluorescence microscopy: Organic dye/nanoparticles/ quantum dots and spectroscopy 4. Raman spectrophotometer: SERS nanotags (Au/Ag), confocal Raman microscopy 5. Sequencing: DNA analysis 6. Bioinformatics: Computer programming 7. Magnetic: Magnetic based sensing 8. Lab on a chip: Microfluidics 9. Imaging: Electron microscopy (AFM/SEM/TEM): Shape and size based analysis 10. Scale up of rapid diagnostics for clinical application: Device development for clinical application 11. Challenges and future prospects of nano-enabled cancer management
Kamil Reza Khondakar is actively involved in developing chip based technology to detect cancer biomarker for the rapid and cost-effective diagnostics of targeted cancer at the Centre of Personalised Medicine in Trau group, at the University of Queensland, Australia. He is a well achieved young scientist and his credential reflects though good quality publications in high impact factor journal such as Small, Biosensor and Bioelectronics, Langmuir etc. He has presented his work in various national and international conferences and workshops. His future research activities include development of biosensors based on nanostructures, nanocomposites utilizing various platforms including microfluidic chip for biomedical applications.
Kaushik, Ajeet Kumar
Dr. Ajeet Kaushik research interests include nano-bio-technology, analytical systems, design & develop nanostructures, nanocarries for drug delivery, nano-therapeutics for CNS diseases, on-demand site-specific release of therapeutic agents, exploring personalized nano-medicines, biosensors, point-of-care sensing devices, and related areas of health care monitoring. He is working as an Assistant Professor to explore "magnetic nanomedicine along with their delivery to the brain for the treatment of NeuroHIV/AIDS and miniaturized electrochemical sensing systems for personalized health care. He is the recipient of various reputed awards for his service in the area of nano-bio-technology for health care. His excellent research credentials reflects by his four edited books, 100 international research peer reviewed publications, and three patents in the area of nanomedicine and smart biosensors for personalized health care.