Nanomedicine for Ischemic Cardiomyopathy: Progress, Opportunities, and Challenges provides an historical overview on myocardial infarction and the available clinical and pre-clinical approaches to inhibit correspondence heart failure. Shortcomings of current methods and how nanotechnology can overcome those obstacles in the field is discussed, including the limitations of newly developed cell therapy approaches to clinical translation and how nanoparticles may overcome crucial issues and facilitate the clinical translation of cell therapy. Biomolecular therapy is also explored as another powerful approach for regeneration of heart tissue, including available methods and the systematic delivery of biomolecules using nano-carriers to the injured part of the myocardium through active targeting.
Finally, coverage of major tissue engineering advances for myocardial regeneration, including use of epicardial nano-structured patches for regeneration of injured epicardium and the highly conductive patches for enhancing cross talks between the cardiomyocytes are explored.
This concise, yet rigorous, coverage outlines the innovative and necessary role of nanotechnology in regenerative medicine for cardiac repair, allowing researchers, clinicians and nanotechnologists to examine the strengths and limitations of current findings and predict future trends.
- Introduces concepts of the unique capacities of cardiac-nanotechnology
- Points to potential and promising applications of engineering nanotechnologies on revolutionizing cell therapy and biomolecular therapy approaches for cardiac regeneration
- Bridges the knowledge gap between cardiologists and cardiac regenerative nanomedicine experts
2. Nanotechnology: A Historical Overview
3. Current Clinical Strategies to Prevent Post Myocardial Infarction Heart Failure
4. Use of Nanoparticulate Systems to Salvage Myocardium
5. Use of Nanoparticulate Systems to Regenerate Myocardium
6. Future trends: Clinicians' Point of View
7. Future trends: Nanotechnologists' Point of View
Dr. Morteza Mahmoudi is an Instructor in the Center for Nanomedicine (Directed by Prof. Farokhzad) and Department of Anesthesiology at Brigham and Women's Hospital (BWH). Before coming to Harvard, he received several postgraduate trainings in nanomedicine and regenerative medicine from University College Dublin (Ireland), École Polytechnique Fédérale de Lausanne (Switzerland), University of Illinois at Urbana-Champaign, and Stanford School of Medicine. His current research is focused on development of innovative regenerative medicine approaches for repair of damaged cardiac and bone tissues.