Hemophilia is an X-linked recessive hemorrhagic disease. It is classified into hemophilia A, a deficiency in clotting factor VIII and hemophilia B, a deficiency in clotting factor IX. Both hemophilia A and hemophilia B are caused by gene mutations.
There is no racial or regional difference in the incidence of hemophilia. In the male population, the incidence of hemophilia A is about 1/5,000, and the incidence of hemophilia B is about 1/25,000. Of all hemophiliacs, patients with hemophilia A account for 80% to 85% and patients with hemophilia B account for 15% to 20%. Hemophilia is rarely seen in women. Because of economic factors and other factors, the incidences of hemophilia vary greatly from one country to another and even vary greatly from one period to another in the same country. It is estimated that there were more than 100,000 hemophiliacs in China at the end of 2018. And most of them failed to receive timely treatment because they had no ability to pay.
Prothrombin complex concentrate (PCC) is made from healthy human plasma. Made up of clotting factors II, VII, IX and X, PCC has been on the global market for more than 50 years. In earlier years, PCC was used to treat hemophilia B. In recent years, with the development of medical technologies and the accumulation of clinical experience, the indications and demand for PCC are expanding.
In China, PCC has been approved to:
- prevent and treat bleeding caused by the deficiency in clotting factors II, VII, IX or X, for example, the bleeding caused by hemophilia B, severe liver diseases (acute severe hepatitis, cirrhosis, etc.), disseminated intravascular coagulation (DIC) and surgeries;
- reverse the bleeding induced by anticoagulants such as coumarins and indandione;
- prevent and treat the bleeding in patients who have hemophilia A and have produced inhibitory antibodies against clotting factor VIII;
- treat newborn babies who have secondary vitamin K deficiency and those who take broad-spectrum antibiotics in severe bleeding or preoperative preparation; and
- treat diphacinone sodium salt poisoning.
According to this market survey, the market size of PCC kept rising after the drug was launched in China. In 2017, it reached about CNY 70 million, representing a CAGR of about 25.90% from 2013 to 2017. PCC is only sold in the dosage form of injection in China. As PCC production requires high technologies, China prohibits the import of PCC and there are few manufacturers of PCC in China, China’s PCC market is highly concentrated with CR5 of more than 90%. In 2017, Hualan Biological Engineering Inc. took up the largest share of China's PCC market. Its market share was about 55% by sales value and about 63% by sales volume. The other major market players were Shandong Taibang Biological Products Co., Ltd., China Meheco Xinxing Pharma Co., Ltd., etc.
It is expected that as the numbers of hemophiliacs and patients with severe liver diseases continue to increase and medical expenses become more affordable to Chinese people with China's economic growth, China's PCC market will have huge growth potential from 2019 to 2023. The high profit rate of PCC is attracting more competitors to the market. For example, in Aug. 2019, Boya Bio-pharmaceutical Group Co., Ltd. announced that its PCC was under the priority review of the Center for Drug Evaluation of China's National Medical Products Administration (NMPA CDE) and was expected to be launched in China in one to two years.
- Incidences of hemophilia and severe liver diseases in China
- Supply of and demand for PCC in China
- Competition on China's PCC market
- Prices of PCC in China
- Major factors influencing the development of China's PCC market
- Prospect of China's PCC market from 2019 to 2023
1 Relevant Concepts of PCC
1.1 Indications for PCC
1.2 Development of PCC in China
1.3 Patents and Government Approval on PCC in China
2 Sales of PCC in China, 2013-2017
2.1 Sales Value of PCC
2.1.1 Overall Sales Value
2.1.2 Sales Value in by Region
2.2 Sales Volume of PCC
2.2.1 Overall Sales Volume
2.2.2 Sales Volume by Region
2.3 Sales of PCC by Dosage Form in China, 2013-2017
2.3.2 Development Trend of Dosage Forms
3 Analysis oF Major PCC Manufacturers in China, 2013-2017
3.1 Analysis on Market Share of Major PCC Manufacturers
3.1.1 Market Share by Sales Value
3.1.2 Market Share by Sales Volume
3.2 China Meheco Xinxing Pharma Co., Ltd.
3.2.1 Enterprise Profile
3.2.2 Sales of PCC by China Meheco Xinxing Pharma Co., Ltd. in China
3.3 Shanghai RAAS Blood Products Co., Ltd.
3.4 Hualan Biological Engineering Inc.
3.5 Shandong Taibang Biological Products Co., Ltd.
3.6 Guizhou Taibang Biological Products Co., Ltd.
3.7 Potential Competitors
4 Prices of PCC in China, 2017-2018
4.1 China Meheco Xinxing Pharma Co., Ltd.
4.2 Shanghai RAAS Blood Products Co., Ltd. (Prothorass)
4.3 Hualan Biological Engineering Inc. (KangShuNing)
4.4 Shandong Taibang Biological Products Co., Ltd.
4.5 Guizhou Taibang Biological Products Co., Ltd.
5 Prospect of China's PCC Market, 2019-2023
5.1 Factors Influencing Development of China's PCC Market
5.1.1 Driving Forces and Market Opportunities
5.1.2 Threats and Challenges
5.2 Forecast on Market Size
5.3 Forecast on Market Trend
Chart Patents on PCC in China
Chart Government Approval on PCC in China
Chart Sales of PCC in China, 2013-2017
Chart Sales Value of PCC in Parts of China, 2013-2017
Chart Sales Volume of PCC in China, 2013-2017
Chart Sales Volume of PCC in Parts of China, 2013-2017
Chart Sales Value of PCC Injections in China, 2013-2017
Chart Market Share of Top 5 PCC Manufacturers by Sales Value, 2013-2017
Chart Market Share of Top 5 PCC Manufacturers by Sales Volume, 2013-2017
Chart Sales Value of PCC by China Meheco Xinxing Pharma Co., Ltd., 2013-2017
Chart Sales Volume of PCC by China Meheco Xinxing Pharma Co., Ltd., 2013-2017
Chart Sales Value of PCC by Shanghai RAAS Blood Products Co., Ltd., 2013-2017
Chart Sales Volume of PCC by Shanghai RAAS Blood Products Co., Ltd., 2013-2017
Chart Prices of PCC by China Meheco Xinxing Pharma Co., Ltd. in Parts of China, 2017
Chart Prices of PCC by Shanghai RAAS Blood Products Co., Ltd. in Parts of China, 2017
Chart Prices of PCC by Hualan Biological Engineering Inc. in Parts of China, 2017
Chart Prices of PCC by Shandong Taibang Biological Products Co., Ltd. in Parts of China, 2017
Chart Prices of PCC by Guizhou Taibang Biological Products Co., Ltd. in Parts of China, 2017
Chart Forecast on Sales Value of PCC in China, 2019-2023
- China Meheco Xinxing Pharma Co., Ltd.
- Guizhou Taibang Biological Products Co., Ltd.
- Hualan Biological Engineering Inc.
- Shandong Taibang Biological Products Co., Ltd.
- Shanghai RAAS Blood Products Co., Ltd.
Background research defines the range of products and industries, which proposes the key points of the research. Proper classification will help clients understand the industry and products in the report.
Secondhand material research is a necessary way to push the project into fast progress. The analyst always chooses the data source carefully. Most secondhand data they quote is sourced from an authority in a specific industry or public data source from governments, industrial associations, etc. For some new or niche fields, they also "double-check" data sources and logics before they show them to clients.
Primary research is the key to solve questions, which largely influence the research outputs. The analyst may use methods like mathematics, logical reasoning, scenario thinking, to confirm key data and make the data credible.
The data model is an important analysis method. Calculating through data models with different factors weights can guarantee the outputs objective.
The analyst optimizes the following methods and steps in executing research projects and also forms many special information gathering and processing methods.
1. Analyze the life cycle of the industry to understand the development phase and space.
2. Grasp the key indexes evaluating the market to position clients in the market and formulate development plans
3. Economic, political, social and cultural factors
4. Competitors like a mirror that reflects the overall market and also market differences.
5. Inside and outside the industry, upstream and downstream of the industry chain, show inner competitions
6. Proper estimation of the future is good guidance for strategic planning.