Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction.
Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion.
- Provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment and prevention of cancer
- Discusses how the properties of specific biomaterials make them important in cancer treatment
- Covers synthetic vaccines, proteins and polymers for cancer therapeutics
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1. Cancer: so common and so difficult to deal with 2. Phenotypic evolution of cancer cells: structural requirements for survival 3. Immunoactive drug carriers in cancer therapy 4. Treating cancer by delivering drug nanocrystals 5. Polymer therapeutics 6. pH-sensitive biomaterials for cancer therapy and diagnosis 7. Nucleic acid anticancer agents 8. Biomaterials for gene editing therapeutics 9. Liquid biopsies for early cancer detection 10. Nanotechnology for cancer screening and diagnosis: from innovations to clinical applications 11. Advances and clinical challenges in biomaterials for in vivo tumor imaging 12. Macroscopic fluorescence lifetime-based Fo ¨rster resonance energy transfer imaging for quantitative ligandreceptor binding 13. Suppression of cancer stem cells 14. Comparison of two- and three-dimensional cancer models for assessing potential cancer therapeutics 15. Engineered tumor models for cancer biology and treatment 16. Cancer mechanobiology: interaction of biomaterials with cancer cells 17. Immunostimulatory materials 18. Biomaterials for cancer immunotherapy 19. Lymph node targeting for improved potency of cancer vaccine 20. Immunogenic clearance-mediated cancer vaccination 21. The future of drug delivery in cancer treatment 22. Development of clinically effective formulations for anticancer applications: why it is so difficult?
Kinam Park is Showalter Distinguished Professor of Biomedical Engineering & Professor of Pharmaceutics at Purdue University, USA. His research focuses in the areas of nano/micro particles, polymer micelles, drug-eluting stents, extracellular matrix, fast dissolving tablets, and smart hydrogels.