Artificial Protein and Peptide Nanofibers: Design, Fabrication, Characterization, and Applications provides comprehensive knowledge of the preparation, modification and applications of protein and peptide nanofibers. The book reviews the synthesis and strategies necessary to create protein and peptide nanofibers, such as self-assembly (including supramolecular assembly), electrospinning, template synthesis, and enzymatic synthesis. Then, the key chemical modification and molecular design methods are highlighted that can be utilized to improve the bio-functions of these synthetic fibers. Finally, fabrication methods for key applications, such as sensing, drug delivery, imaging, tissue engineering and electronic devices are reviewed.
This book will be an ideal resource for those working in materials science, polymer science, chemical engineering, nanotechnology and biomedicine.
- Reviews key chemical modification and molecular design methods to improve the bio-functions of synthetic peptide and protein nanofibers
- Discusses the most important synthesis strategies, including supramolecular assembly, electrospinning, template synthesis and enzymatic synthesis
- Provides information on fabrication of nanofibers for key applications such as sensing, imaging, drug delivery and tissue engineering
1. Synthesis and characterizations of artificial protein and peptide nanofibers 1.1. Amyloid protein nanofibers formed by controlling solution conditions 1.2. Molecule and ions-induced acceleration/inhabitation of peptide nanofibers 1.3. Electrospinning formation of protein and peptide nanofibers 1.4. Nanofibers formed on material surface and interfaces 1.5. Nanofibers formed by designed short peptides 1.6. Molecular dynamics simulations of peptide self-assembly 1.7. Enzyme-promoted formation of peptide nanofibers 1.8. Templated synthesis of protein and peptide nanofibers 1.9. Various characterizations of protein and peptide nanofibers
2. Functional tailoring of artificial protein and peptide nanofibers 2.1. Novel material properties by tailoring the intermolecular forces 2.2. Nanofiber-nanoparticle nanohybrids 2.3. Nanofiber-carbon material nanohybrids 2.4. Nanofiber-polymer nanohybrids 2.5. Amino acid motif design for tailored properties of peptide nanofibers 2.6. Structural design for enhanced functions
3. Applications of artificial protein and peptide nanofibers 3.1. Sensors and Biosensors 3.2. Drug and gene delivery for cancer therapy 3.3. Cellular bioimaging 3.4. Regeneration medicines 3.5. Bone tissue engineering 3.6. Hydrogels and aerogels for cell growth 3.7. Anti-virus and anti-bacterial materials 3.8. Photo/electronic nanodevices 3.9. Energy and environmental materials 3.10. New smart materials
Gang Wei received his Ph.D from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China, in 2007. Following the doctoral studies, he worked as the Alexander-von-Humboldt (2007) and Carl-Zeiss (2009) Postdoctoral Fellow at the Friedrich-Schiller-University of Jena, Germany. Since 2012, he has worked as a senior researcher and group leader in Hybrid Materials Interfaces Group at the University of Bremen, Germany. Since Feb 2018, he has been appointed as a guest professor at the Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences. His research interests include supramolecular self-assembly, biomimetic materials, two-dimensional nanomaterials, sensors and biosensors, as well as single molecule force spectroscopy. Up to now, he has published 100+ peer-reviewed papers in the journals like Chem. Soc. Rev., Prog. Polym. Sci., ACS Nano, Adv. Funct. Mater., Nanoscale Horizons, Nanoscale, Chem. Commun., J. Mater. Chem. B, and others.
Kum bar, Sangamesh G.
Dr. Kumbar is an Assistant Professor in the Departments of Orthopaedic Surgery, Materials Science & Engineering and Biomedical Engineering at the University of Connecticut. His research is focused on synthesis and characterization of novel biomaterials for tissue engineering and drug delivery applications. These polymeric materials namely polysaccharides, polyphosphazenes, polyanhydrides, polyesters as well as blends of two or more of the polymeric materials and composites combining the polymeric materials with ceramics in the form of 3-dimentional porous structures will serve as scaffolds for variety of tissue engineering applications. Dr. Kumbar is an active member of Society for Biomaterials (SFB), Controlled Release Society (CRS), Materials Research Society (MRS) and Orthopaedic Research Society (ORS). Dr. Kumbar is serving as a reviewer for more than 25 journals in the field of biomaterials, drug delivery and tissue engineering. He has recently edited a book "Natural and Synthetic Biomedical Polymers Elsevier Science & Technology, 2014- ISBN: 978-0-12-396983-5. He is also on the Editorial Board of more than 7 journals in the area of his expertise including Journal of Biomedical Materials Research-Part B, Journal of Applied Polymer Science, and Journal of Biomedical Nanotechnology.