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Cold Agglutinin Disease (CAD) - Market Insight, Epidemiology and Market Forecast -2032

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    Report

  • 129 Pages
  • January 2022
  • Region: Global
  • DelveInsight
  • ID: 4845150
This "Cold Agglutinin Disease (CAD)- Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Cold Agglutinin Disease (CAD), historical and forecasted epidemiology as well as the Cold Agglutinin Disease (CAD) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The Cold Agglutinin Disease (CAD) market report provides current treatment practices, emerging drugs, Cold Agglutinin Disease (CAD) market share of the individual therapies, current and forecasted Cold Agglutinin Disease (CAD) market Size from 2019 to 2032 segmented by seven major markets. The Report also covers current Cold Agglutinin Disease (CAD) treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market.

Geography Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2019-2032

Cold Agglutinin Disease (CAD) Disease Understanding and Treatment Algorithm


The Cold Agglutinin Disease (CAD) market report gives a thorough understanding of the Cold Agglutinin Disease (CAD) by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis and treatment.

Diagnosis


This segment of the report covers the detailed diagnostic methods or tests for Cold Agglutinin Disease (CAD).

Treatment


It covers the details of conventional and current medical therapies available in the Cold Agglutinin Disease (CAD) market for the treatment of the condition. It also provides Cold Agglutinin Disease (CAD) treatment algorithms and guidelines in the United States, Europe, and Japan.

Cold Agglutinin Disease (CAD) Epidemiology


The Cold Agglutinin Disease (CAD) epidemiology division provide insights about historical and current Cold Agglutinin Disease (CAD) patient pool and forecasted trend for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of The report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings


The disease epidemiology covered in the report provides historical as well as forecasted Cold Agglutinin Disease (CAD) epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom), and Japan from 2019 to 2032.

Country Wise- Cold Agglutinin Disease (CAD) Epidemiology


The epidemiology segment also provides the Cold Agglutinin Disease (CAD) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

Cold Agglutinin Disease (CAD) Drug Chapters


Drug chapter segment of the Cold Agglutinin Disease (CAD) report encloses the detailed analysis of Cold Agglutinin Disease (CAD) marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Cold Agglutinin Disease (CAD) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

Marketed Drugs


The report provides the details of the marketed product available for Cold Agglutinin Disease (CAD) treatment.

Cold Agglutinin Disease (CAD) Emerging Drugs


The report provides the details of the emerging therapies under the late and mid-stage of development for Cold Agglutinin Disease (CAD) treatment.

Cold Agglutinin Disease (CAD) Market Outlook


The Cold Agglutinin Disease (CAD) market outlook of the report helps to build the detailed comprehension of the historic, current, and forecasted Cold Agglutinin Disease (CAD) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology.

This segment gives a thorough detail of Cold Agglutinin Disease (CAD) market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to the publisher, Cold Agglutinin Disease (CAD) market in 7MM is expected to change in the study period 2019-2032.

Key Findings


This section includes a glimpse of the Cold Agglutinin Disease (CAD) market in 7MM.

The United States Market Outlook


This section provides the total Cold Agglutinin Disease (CAD) market size and market size by therapies in the United States.

EU-5 Countries: Market Outlook


The total Cold Agglutinin Disease (CAD) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom is provided in this section.

Japan Market Outlook


The total Cold Agglutinin Disease (CAD) market size and market size by therapies in Japan is also mentioned.

Cold Agglutinin Disease (CAD) Drugs Uptake


This section focusses on the rate of uptake of the potential drugs recently launched in the Cold Agglutinin Disease (CAD) market or expected to get launched in the market during the study period 2019-2032. The analysis covers Cold Agglutinin Disease (CAD) market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Cold Agglutinin Disease (CAD) Pipeline Development Activities


The report provides insights into different therapeutic candidates in Phase II, and Phase III stage. It also analyses Cold Agglutinin Disease (CAD) key players involved in developing targeted therapeutics.

Pipeline Development Activities


The report covers the detailed information of collaborations, acquisition and merger, licensing, patent details and other information for Cold Agglutinin Disease (CAD) emerging therapies.

Reimbursement Scenario in Cold Agglutinin Disease (CAD)


Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In a report, we take reimbursement into consideration to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.

KOL-Views


To keep up with current market trends, we take KOLs and SME's opinion working in Cold Agglutinin Disease (CAD) domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or Cold Agglutinin Disease (CAD) market trend. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs.

Competitive Intelligence Analysis


The publisher performs Competitive and Market Intelligence analysis of the Cold Agglutinin Disease (CAD) Market by using various Competitive Intelligence tools that include - SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report

  • The report covers the descriptive overview of Cold Agglutinin Disease (CAD), explaining its causes, signs and symptoms, pathophysiology, diagnosis and currently available therapies
  • Comprehensive insight has been provided into the Cold Agglutinin Disease (CAD) epidemiology and treatment in the 7MM
  • Additionally, an all-inclusive account of both the current and emerging therapies for Cold Agglutinin Disease (CAD) are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape
  • A detailed review of Cold Agglutinin Disease (CAD) market; historical and forecasted is included in the report, covering drug outreach in the 7MM
  • The report provides an edge while developing business strategies, by understanding trends shaping and driving the global Cold Agglutinin Disease (CAD) market

Report Highlights

  • In the coming years, Cold Agglutinin Disease (CAD) market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market
  • The companies and academics are working to assess challenges and seek opportunities that could influence Cold Agglutinin Disease (CAD) R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition
  • Major players are involved in developing therapies for Cold Agglutinin Disease (CAD). Launch of emerging therapies will significantly impact the Cold Agglutinin Disease (CAD) market
  • A better understanding of disease pathogenesis will also contribute to the development of novel therapeutics for Cold Agglutinin Disease (CAD)
  • Our in-depth analysis of the pipeline assets across different stages of development (Phase III and Phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities

Cold Agglutinin Disease (CAD) Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Cold Agglutinin Disease (CAD) Pipeline Analysis
  • Cold Agglutinin Disease (CAD) Market Size and Trends
  • Market Opportunities
  • Impact of upcoming Therapies

Cold Agglutinin Disease (CAD) Report Key Strengths

  • 11 Years Forecast
  • 7MM Coverage
  • Cold Agglutinin Disease (CAD) Epidemiology Segmentation
  • Key Cross Competition
  • Highly Analyzed Market
  • Drugs Uptake

Cold Agglutinin Disease (CAD) Report Assessment


Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers

Key Questions Answered


Market Insights:

  • What was the Cold Agglutinin Disease (CAD) market share (%) distribution in 2019 and how it would look like in 2032?
  • What would be the Cold Agglutinin Disease (CAD) total market size as well as market size by therapies across the 7MM during the forecast period (2019-2032)?
  • What are the key findings pertaining to the market across 7MM and which country will have the largest Cold Agglutinin Disease (CAD) market size during the forecast period (2019-2032)?
  • At what CAGR, the Cold Agglutinin Disease (CAD) market is expected to grow in 7MM during the forecast period (2019-2032)?
  • What would be the Cold Agglutinin Disease (CAD) market outlook across the 7MM during the forecast period (2019-2032)?
  • What would be the Cold Agglutinin Disease (CAD) market growth till 2032, and what will be the resultant market Size in the year 2032?
  • How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

  • What is the disease risk, burden and unmet needs of the Cold Agglutinin Disease (CAD)?
  • What is the historical Cold Agglutinin Disease (CAD) patient pool in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
  • What would be the forecasted patient pool of Cold Agglutinin Disease (CAD) in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
  • What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Cold Agglutinin Disease (CAD)?
  • Out of all 7MM countries, which country would have the highest prevalent population of Cold Agglutinin Disease (CAD) during the forecast period (2019-2032)?
  • At what CAGR the population is expected to grow in 7MM during the forecast period (2019-2032)?

Current Treatment Scenario, Marketed Drugs and Emerging Therapies:

  • What are the current options for the Cold Agglutinin Disease (CAD) treatment, along with the approved therapy?
  • What are the current treatment guidelines for the treatment of Cold Agglutinin Disease (CAD) in the USA, Europe, and Japan?
  • What are the Cold Agglutinin Disease (CAD) marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety and efficacy, etc.?
  • How many companies are developing therapies for the treatment of Cold Agglutinin Disease (CAD)?
  • How many therapies are developed by each company for Cold Agglutinin Disease (CAD) treatment?
  • How many are emerging therapies in mid-stage, and late stage of development for Cold Agglutinin Disease (CAD) treatment?
  • What are the key collaborations (Industry - Industry, Industry - Academia), Mergers and acquisitions, licensing activities related to the Cold Agglutinin Disease (CAD) therapies?
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Cold Agglutinin Disease (CAD) and their status?
  • What are the key designations that have been granted for the emerging therapies for Cold Agglutinin Disease (CAD)?
  • What are the global historical and forecasted market of Cold Agglutinin Disease (CAD)?

Reasons to Buy

  • The report will help in developing business strategies by understanding trends shaping and driving the Cold Agglutinin Disease (CAD) market
  • To understand the future market competition in the Cold Agglutinin Disease (CAD) market and Insightful review of the key market drivers and barriers
  • Organize sales and marketing efforts by identifying the best opportunities for Cold Agglutinin Disease (CAD) in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors
  • Organize sales and marketing efforts by identifying the best opportunities for Cold Agglutinin Disease (CAD) market
  • To understand the future market competition in the Cold Agglutinin Disease (CAD) market

Table of Contents

1. Key Insights2. Report Introduction
3. Cold Agglutinin Disease (CAD) Market Overview at a Glance
3.1. Market Share (%) Distribution of CAD in 2019
3.2. Market Share (%) Distribution of CAD in 2032
4. Executive Summary of Cold Agglutinin Disease (CAD)
4.1. Key Events
5. Epidemiology and Market Methodology
6. Disease Background and Overview
6.1. Introduction
6.2. Causes of CAD
6.3. Signs and symptoms of CAD
6.4. Complications of CAD
6.5. Clinical Manifestations of CAD
6.6. Pathophysiology of CAD
6.7. Pathogenesis of CAD
7. Diagnosis of Cold Agglutinin Disease (CAD)
7.1. Diagnostic Algorithm
7.2. Diagnosis Tests
7.2.1. Physical Examination
7.2.2. Imaging technique
7.2.3. Laboratory tests
7.3. Differential Diagnosis
8. Diagnostic Guidelines
8.1. First International Consensus Meeting (2019) recommendations for diagnosis of CAD
8.2. European British Committee for Standards in Haematology (BCSH) recommendations for diagnosis of CAD
9. Treatment of Cold Agglutinin Disease (CAD)
9.1. Treatment Algorithm of CAD
10. Treatment Guidelines
10.1. European British Committee for Standards in Hematology (BCSH) recommendations for treatment of CAD
10.2. First International Consensus Meeting (2019) recommendations for treatment of CAD
11. Epidemiology and Patient Population
11.1. Key Findings
11.2. Epidemiology of Cold Agglutinin Disease (CAD)
11.3. Epidemiology Scenario
11.3.1. Total Prevalent Cases of Cold Agglutinin Disease (CAD)
11.3.2. Total Diagnosed Cases of Cold Agglutinin Disease (CAD)
11.3.3. Total Gender-specific Cases of Cold Agglutinin Disease (CAD)
11.3.4. Total Type-specific Cases of Cold Agglutinin Disease (CAD)
11.3.5. Total Treated Cases of Cold Agglutinin Disease (CAD)
12. Patient Journey13. Key Endpoints in Cold Agglutinin Disease Clinical Trials
14. Emerging Therapies
14.1. BIVV009 (sutimlimab): Sanofi/Bioverativ
14.1.1. Product Description
14.1.2. Other development activities
14.1.3. Clinical Development
14.1.4. Safety and Efficacy
14.2. Aspaveli/Empaveli (pegcetacoplan; APL-2): Sobi/Apellis Pharmaceuticals
14.2.1. Product Description
14.2.2. Other development activities
14.2.3. Clinical Development
14.2.4. Safety and Efficacy
14.3. LNP023 (iptacopan): Novartis
14.3.1. Product Description
14.3.2. Other Development Activities
14.3.3. Clinical development
14.4. INCB050465 (parsaclisib): Incyte Corporation
14.4.1. Product Description
14.4.2. Other Development Activities
14.4.3. Clinical development
14.4.4. Safety and Efficacy
14.5. BIVV020 (SAR445088): Bioverativ/Sanofi
14.5.1. Clinical development
15. Cold Agglutinin Disease (CAD): 7 Major Market Analysis
15.1. Key Findings
15.2. Market Outlook
15.3. Market Size of Cold Agglutinin Disease (CAD)
15.3.1. Total Market Size of Cold Agglutinin Disease
15.3.2. Market Size of Cold Agglutinin Disease by Therapies
16. Market Access and Reimbursement
16.1. Key HTA decisions for PNH
17. KOL Views18. Market Drivers19. Market Barriers20. SWOT Analysis21. Unmet Needs
22. Appendix
22.1. Bibliography
22.2. Report Methodology
23. Capabilities24. Disclaimer25. About the Publisher
List of Tables
Table 1: Summary of Cold Agglutinin Disease, Market, Epidemiology, and Key Events (2019-2032)
Table 2: Total Prevalent Cases of Cold Agglutinin Disease (CAD) (2019-2032)
Table 3: Total Diagnosed Cases of Cold Agglutinin Disease (CAD) (2019-2032)
Table 4: Total Gender-specific Cases of Cold Agglutinin Disease (CAD) (2019-2032)
Table 5: Total Type-specific Cases of Cold Agglutinin Disease (CAD) (2019-2032)
Table 6: Total Treated Cases of Cold Agglutinin Disease (CAD) (2019-2032)
Table 7: Sutinlimab (BIVV009), Clinical Trial Description, 2022
Table 8: Aspaveli/Empaveli (Pegcetacoplan; APL-2), Clinical Trial Description, 2022
Table 9: Iptacopan (LNP023), Clinical Trial Description, 2022
Table 10: Parsaclisib (INCB050465), Clinical Trial Description, 2022
Table 11: BIVV020 (SAR445088), Clinical Trial Description, 2022
Table 12: 7MM Market Size of Cold Agglutinin Disease in USD Million (2019-2032)
Table 13: 7MM Market Size of Cold Agglutinin Disease by Therapies in USD Million (2019-2032)
Table 14: Key HTA Decisions for PNH
List of Figures
Figure 1: Epidemiology and Market Methodology
Figure 2: Antibody-Mediated Hemolysis
Figure 3: Signs and Symptoms of CAD
Figure 4: Pathophysiology of CAD
Figure 5: Diagnostic algorithm for CAD
Figure 6: Typical acrocyanosis exacerbated by cold exposure
Figure 7: Diagnostic test using Nailfold capillaroscopy
Figure 8: Pharmacological management of CAD
Figure 9: Treatment Algorithm of CAD
Figure 10: Total Prevalent Cases of Cold Agglutinin Disease (CAD) in the 7MM (2019-2032)
Figure 11: Total Diagnosed Cases of Cold Agglutinin Disease (CAD) in the 7MM (2019-2032)
Figure 12: Total Gender-specific Cases of Cold Agglutinin Disease (CAD) in the 7MM (2019-2032)
Figure 13: Total Type-specific Cases of Cold Agglutinin Disease (CAD) in the 7MM (2019-2032)
Figure 14: Total Treated Cases of Cold Agglutinin Disease (CAD) in the 7MM (2019-2032)
Figure 15: Market Size of Cold Agglutinin Disease in the 7MM, USD Million (2019-2032)
Figure 16: 7MM Market Size of Cold Agglutinin Disease by Therapies in USD Million (2019-2032)

Companies Mentioned

A selection of companies mentioned in this report includes:

  • Sanofi
  • Bioverativ
  • Sobi
  • Apellis Pharmaceuticals
  • Novartis
  • Incyte Corporation