Drug Overview
Fostemsavir (GSK3684934) (ViiV Healthcare), previously known as BMS-663068, is an oral prodrug of GSK2616713 (formerly BMS-626529). It is an attachment inhibitor which binds to the gp120 protein of HIV to prevent viral attachment to the host CD4+ T cells, which is necessary for entry into host cells. In December 2015, fostemsavir was acquired by ViiV Healthcare, which is now responsible for the development of the drug.
Fostemsavir is a novel oral attachment inhibitor being developed for use in multidrug-resistant patients, where there is significant unmet need for novel modes of action. Fostemsavir’s key differentiator over recently approved intravenous monoclonal antibody Trogarzo (ibalizumab; Theratechnologies/TaiMed Biologics) is its more convenient oral twice-daily dosing, which is expected to lower treatment costs for payers and patients. However, fostemsavir’s twice-daily dosing schedule is expected to preclude future progression to the earlier lines of therapy, where a plethora of more convenient once-daily regimens currently dominate.
Fostemsavir (GSK3684934) (ViiV Healthcare), previously known as BMS-663068, is an oral prodrug of GSK2616713 (formerly BMS-626529). It is an attachment inhibitor which binds to the gp120 protein of HIV to prevent viral attachment to the host CD4+ T cells, which is necessary for entry into host cells. In December 2015, fostemsavir was acquired by ViiV Healthcare, which is now responsible for the development of the drug.
Fostemsavir is a novel oral attachment inhibitor being developed for use in multidrug-resistant patients, where there is significant unmet need for novel modes of action. Fostemsavir’s key differentiator over recently approved intravenous monoclonal antibody Trogarzo (ibalizumab; Theratechnologies/TaiMed Biologics) is its more convenient oral twice-daily dosing, which is expected to lower treatment costs for payers and patients. However, fostemsavir’s twice-daily dosing schedule is expected to preclude future progression to the earlier lines of therapy, where a plethora of more convenient once-daily regimens currently dominate.
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