Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders

Table of Contents

1. Insulin resistance and obesity2. Insulin resistance, diabetes, and metabolic syndrome3. Insulin resistance and heart disease4. Insulin resistance and sleep apnea5. Insulin resistance and stroke6. Insulin resistance and Alzheimer's disease7. Insulin resistance and Parkinson's disease8. Insulin resistance, dementia, and depression9. Use of phytochemicals for the treatment of insulin resistance-linked visceral and neurological disorders10. Summary and perspective for future research on insulin resistance and insulin resistance-linked visceral and neurological disorders

Authors

Akhlaq A. Farooqui Research Scientist, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA. Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases, glutamate neurotoxicity, and neurological disorders. He is a research scientist in the Department of Molecular and Cellular Biochemistry at The Ohio State University. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics. He has studied the involvement of glycerophospholipid, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases. Akhlaq A. Farooqui has discovered the stimulation of plasmalogen- selective phospholipase A2 in brains of patients with Alzheimer disease (AD). Stimulation of this enzyme may not only be responsible for the deficiency of plasmalogens in neural membranes of AD patients, but also be related to the loss of synapse in the AD.