Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies.
- Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment
- Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology
- Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators
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2. Autophagosome biogenesis
3. Autophagy in T and B cell homeostasis: Recycling for sustainable growth
4. Autophagy is involved in quality/quantity control of organelles and their homeostasis
5. Role of autophagy in immune regulation
6. Autophagy in natural and therapy-driven anticancer immunosurveillance
7. Autophagy and resistance to cell-mediated cytotoxicity
8. Autophagy and metabolism
9. Autophagy in connecting immunity and metabolism
10. Autophagy in tumor cell migration and invasion, tumor stem cell maintenance and therapy resistance
11. Autophagy during Early Virus-Host Cell Interactions
12. Diverse roles for autophagy in impeding and promoting tumorigenesis
13. The autophagic network and cancer
14. Targeting Autophagy in the Tumor Microenvironment
15. Autophagy and microbiota
16. Regulation of autophagy and mitochondrial dynamics
17. Autophagy proteins in cell defenses and role in bacteria-macrophage interaction
18. Autophagy, a key player in leukemogenesis and a therapeutic target in hematopoietic malignancies
19. Autophagy in Cancer and Cancer Therapy
20. Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?
21. Autophagy and cancer therapy
22. Therapeutic potential of autophagy modulation in the clinic
23. Rationale and current approaches for developing autophagy inducers in medicine
24. Autophagy and metabolism
For more than 20 years Dr. Salem Chouaib has focused his research on killer cells and cell death; he first was interested in the differentiation of cytotoxic T lymphocytes, then in the molecular basis of tumor resistance to the cytotoxic action of TNF. During the past ten years, Dr. Chouaib's research was devoted to the influence of tumor microenvironment on stroma reactivity and tumor heterogeneity. His team was the first to establish the link between hypoxic stress and the acquisition of tumor resistance to cell-mediated cytotoxicity; they found in fact that autophagy was a potential pathway linking hypoxia to the acquisition of resistant phenotype including stemness and epithelial to mesenchymal transition. Dr. Chouaib has a wide knowledge of the killing mechanisms and the tumor resistance as well.