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Technological Advances in Gastrointestinal Imaging and Diagnosis

  • Report

  • 64 Pages
  • November 2019
  • Region: Global
  • Frost & Sullivan
  • ID: 4860901

Analysis of Current and Developing Technologies in Endoscopy, Colonoscopy, Associated Accessories, Capsule Endoscopy, Molecular Diagnosis and Imaging, AI Applications, and Contrast Agents

The gastrointestinal tract has been one of the most difficult areas to evaluate with available imaging standards. Since the introduction of the endoscope in the 1960s, there have been continuous advances in endoscopy by replacing fiberoptics with CCD (Charge-coupled device) detectors. The Japanese method of staining mucosa with dye-spray called “chromoendoscopy” assisted diagnosis, however, did not get momentum in the western world due to time-intensive and learning curves associated with it. Previous GIT studies lacked sensitivity and specificity, and recent developments have transformed the field of GIT imaging.

White light endoscopy was the benchmark for detection of GIT disorders; however, there was still a high rate of misdiagnosis. High definition (HD) endoscopy has improved the detection of GIT abnormalities like neoplastic, pre-neoplastic or inflammatory conditions. Further developments in imaging such as image-enhanced endoscopy, magnification, endo-microscopy, or virtual intelligence have enhanced histological predictions.

Video capsule endoscopy (VCE) is extremely useful in for diagnosis and management of GIT disorders due to non-invasive ability throughout image capturing and ability to cover the entire GI tract. VCE is particularly helpful for small bowel imaging, however, it comes with its own limitations.

Ultrasound being ionizing radiation-free and provides real-time results, particularly useful in pediatric applications. Contrast-enhanced ultrasound and hydro sonography are the latest developments. Cross-sectional imaging techniques such as CT, MRI, and PET are being used to support evaluation further.

A colonoscopy helps reduce the mortality associated with colorectal cancer (CRC) through detection and resection of neoplastic polyps; however, polyps detection can go unnoticed even by experienced and trained physicians with an accuracy rate of around 80%*. To address this challenge computer-aided diagnosis (CAD) is attracting attention to help endoscopists avoid missing polyps.

Molecular probes and antibodies have enabled a combination approach by integrating fundamental research and clinical endoscopy. During molecular imaging, cellular structures are labelled with molecular probes or antibodies and visualized through endoscopy, enabling characterization of the molecular profile of tissues.

Imaging tests performed can suggest the presence of cancer while biopsy or genomic can make a definite diagnosis.

Table of Contents

1. Executive Summary
1.1 Research Background: Addressing the Gaps in Gastrointestinal Tract Imaging and Diagnosis
1.2 Research Scope: Advances in Gastrointestinal Tract Imaging and Diagnosis
1.3 Analysis Framework
1.4 Research Methodology: Five Steps Toward Success
1.5 Key Findings of GIT imaging and Diagnosis
2. Technology Snapshot
2.1 Areas Covered in This Research Study
2.2 Gastrointestinal Anatomy, Physiology and Pathophysiology
2.3 Endoscope Development Timeline
3. Innovations in Endoscopy, Colonoscopy, Diagnostic Devices, and Accessories
3.1 Endoscopic Ultrasound Enhanced Imaging with Two Focus Setting
3.2 Safer Endoscopic Ultrasound System to Avoid Needle Injuries
3.3 Endoscopy with Advanced Visualization and Illumination
3.4 Multiple Endo-imaging Solutions
3.5 Rapid Bowel Cleansing During Colonoscopy Procedures
3.6 Endoscopes with a Range of Lengths, Diameters, and Flexibilities
3.7 Probe-based Confocal Laser Endomicroscopy Platform
3.8 A Line of Accessories for Endoscopic Procedures
3.9 Endoscopy Ultrasound-guided Fine Needle Aspiration and Biopsy
3.10 High-Resolution Manometry and Breath Testing for GI Disorders
3.11 Simultaneous Dissection, Resection, and Collection of Tissue During Endoscopy
3.12 Innovative Balloon Technology for Colonoscopy
3.13 Innovative Balloon Technology Overcoming Conventional Limitations of GI Endoscopy
4. Computer-aided Diagnosis
4.1 Overview: Computer-aided Diagnosis for GIT Disorder
4.2 Participants in CAD for GIT Disorders
5. Non-invasive Endoscopy: Capsule Endoscopy
5.1 Need for Capsule Endoscopy, Types, and Developments
5.2 Leading Participants in Capsule Endoscopy, Their Products and Applications
5.3 Capsule Endoscope that Auto-screens Clinically Significant Images
5.4 Capsule Endoscope with 360 Degree Panoramic Imaging View
5.5 Capsule Endoscopy with Ultralow X-rays and Wireless Technology
5.6 Battery-free Technology in Capsule Endoscopy
5.7 Other Capsule Endoscopic Technologies in the Market
5.8 Recent Development in Capsule Endoscopy by Massachusetts General Hospital
5.9 SONOPILL: Exploring New Avenues in Ultrasound Capsule Endoscopy
5.10 Commercial and Academic Partners of Sonopill
6. Molecular Imaging for GIT Disorder Diagnosis
6.1 Molecular Endoscopic Imaging (MEI)
6.2 Summary of Major Molecular Endoscopic Imaging Studies of Esophagus and Stomach
6.3 Summary of Major Molecular Endoscopic Imaging Studies of Colon
6.4 Future and Challenges of MEI
6.5 Characteristics of Various Probes Used for Molecular Imaging
7. Molecular Diagnosis for GIT Disorders
7.1 Types and Importance of Non-invasive Fecal Diagnostic Tests
7.2 Non-invasive Colon Cancer Detection Kit
7.3 Non-invasive Fecal Diagnostic Tests for Colorectal Cancer
8. Contrast Agent for GIT Imaging
8.1 Administration and Features of Contrast Agents
8.2 Contrast Agents for CT
8.3 Contrast Agents for Fluoroscopy
9. Growth Opportunities
9.1 Five Major Growth Opportunities
9.2 Strategic Imperatives
10. Key Industry Influencers
10.1 Industry Interactions