Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms.
- Features leading experts in various subfields as section editors and article authors
- Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship
- Covers disorders of the nervous system that arise through defects in neural development
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1. Neural-Tube Defects 2. Fetal Alcohol Spectrum Disorder: Targeted Effects of Ethanol on Cell Proliferation and Survival 3. Azetidine-2-Carboxylic Acid and Other Nonprotein Amino Acids in the Pathogenesis of Neurodevelopmental Disorders 4. Down Syndrome 5. Lissencephalies and Axon Guidance Disorders 6. Developmental Disabilities, Autism, and Schizophrenia at a Single Locus: Complex Gene Regulation and Genomic Instability of 15q11-q13 Cause a Range of Neurodevelopmental Disorders 7. Fragile X Clinical Features and Neurobiology 8. Autisms 9. Neurodevelopmental Genomics of Autism, Schizophrenia, and Related Disorders 10. Excitation-Inhibition Epilepsies 11. Sensory Organ Disorders (Retina, Auditory, Olfactory, Gustatory) 12. The Developmental Neurobiology of Repetitive Behavior 13. Disorders of Cognitive Control 14. Language Impairment 15. New techniques in quantitative genetics 16. Network analysis and disease modelling 17. Zika virus 18. iPS as a model for human developmental disorders 19. Down syndrome 20. Rett syndrome 21. Astrocytes in neurological and psychiatric disorders 22. Intellectual disability 23. Tourette 24. Primate models of brain disorders
Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health.
Kwan, Kenneth Y.
Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.