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Neurodevelopmental Disorders. Comprehensive Developmental Neuroscience

  • Book

  • May 2020
  • Elsevier Science and Technology
  • ID: 4894725

Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms.

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Table of Contents


1. Neurocutaneous Syndromes: Neurofibromatosis and Tuberous Sclerosis

Mustafa Sahin

2. Azetidine-2-Carboxylic Acid and Other Nonprotein Amino Acids in the Pathogenesis of Neurodevelopmental Disorders

Edward Rubenstein

3. Autisms

Antonio M. Persico

4. Developmental basis of ZIKA virus induced neuropathology

Hongjun Song and Guo-li Ming

5. iPSC Models of Human Neurodevelopmental Disorders

Flora M. Vaccarino

6. Cornelia de Lange Syndrome: Insights into Neural Development from Clinical Studies and Animal Models

Anne Leighton Calof, Rosaysela Santos, Laura Groves, Chris Oliver and Arthur D. Lander

7. Fetal Alcohol Spectrum Disorder

Sandra Mooney

8. Neural Tube Defects

Lee Niswander

9. Developmental disabilities, autism and schizophrenia at a single locus: complex gene regulation and genomic instability of 15q11-q13 cause a range of neurodevelopmental disorders

Lawrence T. Reiter

10. Lissencephalies

Elliott Sherr and Bethany Johnson-Kerner

11. Rett Syndrome

Jeffrey Lorenz Neul

12. Focal Cortical Dysplasias

Christopher A. Walsh and Alissa M. D'Gama

13. White Matter Disorders

Benjamin Lawrence Lynner Clayton, Paul Tesar, Kevin Cameron Allan, Zachary Scott Nevin and Matthew Sean Elitt

14. Language Impairments

R. Holly Fitch

15. Fragile X Syndrome

Randi Hagerman

16. Microcephalies

Youngshin Lim and Jeffrey Alan Golden


Bin Chen Professor of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, USA. Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health. Kenneth Y. Kwan Assistant Professor of Human Genetics and Research Assistant Professor, Molecular and Behavioral Neuroscience Institute, University of Michigan, USA. Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.