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Handbook of Toxicology of Chemical Warfare Agents. Edition No. 3

  • ID: 4911817
  • Book
  • July 2020
  • Region: Global
  • 1200 Pages
  • Elsevier Science and Technology
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Handbook of Toxicology of Chemical Warfare Agents, Third Edition covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, and countermeasures.

Expanding on the second edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a new chapter on emergency preparedness, coverage of the chemical warfare agents used in Syria, the use of the Novichok agent in the UK, and more.

  • Unites world-leading experts to bring you cutting-edge, agent-specific information on Chemical Warfare Agents (CWA) and their adverse effects on human and animal health, and the environment
  • Provides you with all the information you need on CWA modes of action, detection, prevention, therapeutic treatment and countermeasures
  • New to this edition: a full update to reflect the most recent advances in the field and new chapters on emergency preparedness, the chemical warfare agents used in Syria, and the use of the Novichok agent in the UK
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Section I: Historical Perspective and Epidemiology 1. History of Toxicology: From Killers to Healers 2. Historical Perspective of Chemical Warfare Agents 3. Global Impact of Chemical Warfare Agents Used Before and After 1945    4. Sarin Attacks in Japan: Acute and Delayed Health Effects in Survivors 5. Early and Delayed Effects of Sulfur Mustard in Iranian Veterans After the Iraq-Iran Conflict 6. Epidemiology of Chemical Warfare Agents 7. Chemical Weapons of Mass Destruction and Terrorism: A Threat Analysis

Section II: Agents That Can Be Used as Weapons of Mass Destruction 8. Organophosphate Nerve Agents 9. Russian VX 10. Novichoks 11. Blister Agents 12. Riot Control Agents 13. Phosgene oxime 14. Psychotomimetic Agent BZ (3-Quinuclidinyl Benzilate) 15. Fluoroacetate 16. Strychnine 17. Superwarfarins 18. PCBs, Dioxins and Furans: Human Exposure and Health Effects   19. Polycyclic Aromatic Hydrocarbons: Implications for Developmental, Molecular, and Behavioral Neurotoxicity 20. Thallium 21. Arsenicals: Toxicity, Their Use as Chemical Warfare Agents, and Possible Remedial Measures 22. Chlorine 23. Phosgene 24. Carbon Monoxide: Can't See, Can't Smell, Body Looks Red But They Are Dead 25. Acute Cyanide Toxicity and its Treatment: The Body is Dead and Maybe Red but Does Not Stay Red for Long 26. Methyl Isocyanate: The Bhopal Gas 27. Other Toxic Chemicals as Potential Chemical Warfare Agents 28. Ricin 29. Botulinum Toxin 30. Onchidal and Fasciculins 31. Cyanobacterial (Blue-Green Algae) Toxins

Section III: Target Organ Toxicity 32. Chemical Warfare Agents and the Nervous System 33. Behavioral Toxicity of Nerve Agents 34. The Respiratory Toxicity of Chemical Warfare Agents 35. Cardiovascular System as a Target of Chemical Warfare Agents 36. Ocular Toxicity of Chemical Warfare Agents 37. Skeletal Muscle 38. Dermal Toxicity of Sulfur Mustard 39. Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents 40. Liver Toxicity of Chemical Warfare Agents 41. Renal System 42. Impact of Chemical Warfare Agents on the Immune System

Section IV: Special Topics 43. Health Effects of Nuclear Weapons and Releases of Radioactive Materials 44. Clinical and Cellular Aspects of Traumatic Brain Injury 45. Neurological Effects and Mechanisms of Blast Overpressure Injury 46. Genomics and Proteomics in Brain Complexity in Relation to Chemically-Induced PTSD 47. Excitotoxicity, Oxidative Stress, and Neuronal Injury 48. Blood-Brain Barrier Damage and Dysfunction by Chemical Toxicity 49. The Effects of Organophosphates in the Early Stages of Human Skeletal Muscle Regeneration 50. Experimental modeling for delayed effects of organophosphates 51. Alternative Animal Toxicity Testing of Chemical Warfare Agents

Section V: Toxicokinetics, Toxicodynamics and Physiologically-Based Pharmacokinetics 52. Toxicokinetic Aspects of Nerve Agents and Vesicants 53. Toxicokinetics and Toxicodynamics of DFP 54. Physiologically Based Pharmacokinetic Modeling of Chemical Warfare Agents 55. Biotransformation of Warfare Nerve Agents

Section VI: Analytical Methods, Biosensors and Biomarkers 56. Laboratory Analysis of Chemical Warfare Agents, Adducts, and Metabolites in Biomedical Samples 57. On-Site Detection of Chemical Warfare Agents 58. Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed Neuropathic Agents 59. The crosslinking action of organophosphorus poisons; implications for chronic neurotoxicity 60. Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Section VII: Risks to Animals and Wildlife 61. Potential Agents That Can Cause Contamination of Animal Feedingstuff and Terror 62. Chemical Warfare Agents and Risks to Animal Health 63. Threats to Wildlife by Chemical and Warfare Agents

Section VIII: Emergency Preparedness, Prophylactic, Therapeutic and Countermeasures 64. Pharmacological Prophylaxis Against Nerve Agent Poisoning: Experimental Studies and Practical Implications  65. Prophylactic and Therapeutic Measures in Nerve Agents Poisoning 66. Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling of Countermeasures to Nerve Agents 67. Research on Medical Countermeasures for Chemical Attacks on Civilians 68. Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds 69. Novel Cholinesterase Reactivators 70. Paraoxonase (PON1), detoxication of nerve agents, and modulation of their toxicity 71. The role of carboxylesterases in therapeutic interventions of nerve agent poisoning 72. Catalytic bioscavengers: the new generation of bioscavenger-based medical countermeasures

Section IX: Decontamination and Detoxification 73. Rapid Decontamination of Chemical Warfare Agents from the Skin

Section I: Historical Perspective and Epidemiology 1. History of Toxicology: From Killers to Healers 2. Historical Perspective of Chemical Warfare Agents 3. Global Impact of Chemical Warfare Agents Used Before and After 1945    4. Sarin Attacks in Japan: Acute and Delayed Health Effects in Survivors 5. Early and Delayed Effects of Sulfur Mustard in Iranian Veterans After the Iraq-Iran Conflict 6. Epidemiology of Chemical Warfare Agents 7. Chemical Weapons of Mass Destruction and Terrorism: A Threat Analysis

Section II: Agents That Can Be Used as Weapons of Mass Destruction 8. Organophosphate Nerve Agents 9. Russian VX 10. Novichoks 11. Blister Agents 12. Riot Control Agents 13. Phosgene oxime 14. Psychotomimetic Agent BZ (3-Quinuclidinyl Benzilate) 15. Fluoroacetate 16. Strychnine 17. Superwarfarins 18. PCBs, Dioxins and Furans: Human Exposure and Health Effects   19. Polycyclic Aromatic Hydrocarbons: Implications for Developmental, Molecular, and Behavioral Neurotoxicity 20. Thallium 21. Arsenicals: Toxicity, Their Use as Chemical Warfare Agents, and Possible Remedial Measures 22. Chlorine 23. Phosgene 24. Carbon Monoxide: Can't See, Can't Smell, Body Looks Red But They Are Dead 25. Acute Cyanide Toxicity and its Treatment: The Body is Dead and Maybe Red but Does Not Stay Red for Long 26. Methyl Isocyanate: The Bhopal Gas 27. Other Toxic Chemicals as Potential Chemical Warfare Agents 28. Ricin 29. Botulinum Toxin 30. Onchidal and Fasciculins 31. Cyanobacterial (Blue-Green Algae) Toxins

Section III: Target Organ Toxicity 32. Chemical Warfare Agents and the Nervous System 33. Behavioral Toxicity of Nerve Agents 34. The Respiratory Toxicity of Chemical Warfare Agents 35. Cardiovascular System as a Target of Chemical Warfare Agents 36. Ocular Toxicity of Chemical Warfare Agents 37. Skeletal Muscle 38. Dermal Toxicity of Sulfur Mustard 39. Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents 40. Liver Toxicity of Chemical Warfare Agents 41. Renal System 42. Impact of Chemical Warfare Agents on the Immune System

Section IV: Special Topics 43. Health Effects of Nuclear Weapons and Releases of Radioactive Materials 44. Clinical and Cellular Aspects of Traumatic Brain Injury 45. Neurological Effects and Mechanisms of Blast Overpressure Injury 46. Genomics and Proteomics in Brain Complexity in Relation to Chemically-Induced PTSD 47. Excitotoxicity, Oxidative Stress, and Neuronal Injury 48. Blood-Brain Barrier Damage and Dysfunction by Chemical Toxicity 49. The Effects of Organophosphates in the Early Stages of Human Skeletal Muscle Regeneration 50. Experimental modeling for delayed effects of organophosphates 51. Alternative Animal Toxicity Testing of Chemical Warfare Agents

Section V: Toxicokinetics, Toxicodynamics and Physiologically-Based Pharmacokinetics 52. Toxicokinetic Aspects of Nerve Agents and Vesicants 53. Toxicokinetics and Toxicodynamics of DFP 54. Physiologically Based Pharmacokinetic Modeling of Chemical Warfare Agents 55. Biotransformation of Warfare Nerve Agents

Section VI: Analytical Methods, Biosensors and Biomarkers 56. Laboratory Analysis of Chemical Warfare Agents, Adducts, and Metabolites in Biomedical Samples 57. On-Site Detection of Chemical Warfare Agents 58. Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed Neuropathic Agents 59. The crosslinking action of organophosphorus poisons; implications for chronic neurotoxicity 60. Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

Section VII: Risks to Animals and Wildlife 61. Potential Agents That Can Cause Contamination of Animal Feedingstuff and Terror 62. Chemical Warfare Agents and Risks to Animal Health 63. Threats to Wildlife by Chemical and Warfare Agents

Section VIII: Emergency Preparedness, Prophylactic, Therapeutic and Countermeasures 64. Pharmacological Prophylaxis Against Nerve Agent Poisoning: Experimental Studies and Practical Implications  65. Prophylactic and Therapeutic Measures in Nerve Agents Poisoning 66. Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling of Countermeasures to Nerve Agents 67. Research on Medical Countermeasures for Chemical Attacks on Civilians 68. Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds 69. Novel Cholinesterase Reactivators 70. Paraoxonase (PON1), detoxication of nerve agents, and modulation of their toxicity 71. The role of carboxylesterases in therapeutic interventions of nerve agent poisoning 72. Catalytic bioscavengers: the new generation of bioscavenger-based medical countermeasures

Section IX: Decontamination and Detoxification 73. Rapid Decontamination of Chemical Warfare Agents from the Skin

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Gupta, Ramesh C.
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in research on pesticide toxicity, neurodegenerative diseases, and nutraceuticals efficacy and safety. He has delivered lectures in UK, Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, Sweden, and Turkey. He served the panels of NIH, CDC, NIOSH, and NAS. He has >450 publications to his credit, including seven major books: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology, (7) Nutraceuticals: Efficacy, Safety and Toxicity, and (8) Nutraceuticals in Veterinary Medicine. He is recipient of Murray State University's distinguished researcher award of the year-2006, and Outstanding research award of the year 2014. In 2019, he received a medal from The Royal Academy of Spanish Veterinary Sciences for his distinguished services to veterinary medicine. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences. Dr. Gupta is a member of many professional societies, including SOT, Eurotox, ASPET, American College of Toxicology, and ISSX.
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