Gastroparesis: Pathophysiology, Clinical Presentation, Diagnosis and Treatment is a centralized source of data on gastroparesis collected over the last decade. Contents include the pathophysiology, clinical presentation, diagnostic considerations and treatment options for gastroparesis. The reference is split into broad subsections, with the philosophy of first focusing on the key features of the disease (clinical presentation, pathophysiology, diagnosis, clinical subsets and treatment) and then turning to controversies, recent developments, patient support resources and speculations on the future.
Chapters will include coverage of important topics like autonomic neuropathy, gastroparesis and the brain-gut axis, potential pharmacologic advances targeted to the cellular level, diagnostic and therapeutic options targeted at the pylorus and the evaluation of the female predominance in gastroparesis. This is a must-have resource for scientists looking to find the next step in their research as well as healthcare professionals struggling with how to optimally take care of their patients.
- Provides a comprehensive overview of what is known regarding the pathophysiology, clinical presentation, diagnostic considerations and treatment options for gastroparesis
- Includes key updates in the field from the past decade including the progress made by the NIH Gastroparesis Consortium
- Presents both sides of key controversies in the field, including the debate between classification of gastroparesis versus functional dyspepsia
1. Historical perspectives on gastric motility 2. Epidemiology of gastroparesis 3. Clinical presentations of gastroparesis 4. Natural history of patients with gastroparesis 5. Foregut dysmotility at the organ level in gastroparesis 6. Cellular pathogenesis of gastroparesis 7. Sensory dysfunction in gastroparesis 8. Pathology of Gastroparesis 9. Gastroparesis and the brain gut axis 10. Autonomic neuropathy and gastroparesis 11. Gastric emptying scintigraphy 12. Wireless motility capsule in gastroparesis 13. Breath tests for assessment of gastric emptying 14. Magnetic resonance imaging for gastric motility 15. Electrogastrography for suspected gastroparesis 16. Is there still a role for antroduodenal manometry? 17. Ancillary testing including barostat, SPECT and satiety testing 18. Diabetic gastroparesis 19. Postsurgical gastroparesis 20. Idiopathic gastroparesis 21. Gastroparesis from other causes 22. Pediatric gastroparesis 23. Dietary therapy for gastroparesis 24. Prokinetic agents for gastroparesis 25. Antiemetic therapy for gastroparesis 26. Pain management and sensory neuromodulations for gastroparesis 27. Psychiatric aspects of gastroparesis 28. Alternative and complementary medicine for gastroparesis 29. Enteric tube placement for gastroparesis: gastrostomy, gastrojejunostomy and jejunostomy 30. Gastric electrical stimulation for gastroparesis 31. Surgical considerations: G-POEM, pyloromyotomy, gastrojejunostomy and resection 32. The NIH Gastroparesis Clinical Research Consortium: lessons learned over the past decade 33. Potential pharmacologic advances targeted to the cellular level 34. The pyloric revolution: patient selection 35. Endoscopic full-thickness gastric biopsy: Ready for prime time? 36. Distinguishing between functional dyspepsia and gastroparesis: Does it matter? 37. Evaluation of the female predominance of gastroparesis 38. A brief history and future directions for permanent, temporary and endoscopic GES 39. Stem cell transplantation for gastroparesis 40. Speculations on the future of gastroparesis research, diagnostics and therapy 41. Resources for the gastroparesis patient
Richard W. McCallum is recognized internationally as a premier thought leader in the field of neurogastroenterology and gastrointestinal motility. He is professor and founding chair of the Department of Internal Medicine at Texas Tech University Health Sciences Center and chief of its Division of Gastroenterology, Hepatology and Nutrition. He is also director of the Center for Neurogastroenterology and GI Motility.
McCallum pioneered the use of gastric electrical stimulation to treat gastroparesis, instigating a new direction of treatment for patients with nausea and vomiting. He is also a central figure in clinical research trials studying all the major prokinetics-drugs that enhance gastrointestinal motility-as well as antiemetics- agents working in the brain to block nausea. His scientific publications in peer-reviewed journals exceed 450, and he has edited more than a dozen scientific textbooks. He holds five patents.
McCallum has held several important leadership roles at the American College of Gastroenterology, the American Gastroenterological Association, the American Neurogastroenterology and Motility Society, and the Southern Society for Clinical Investigation. He has held editorial responsibilities with several major journals. He has been honored by Texas Tech University, the American Gastroenterological Association, the American Diabetes Association, the Texas Medical Association, and the Southern Society for Clinical Research. His research on the pathophysiology and treatments for gastroparesis has been funded by the National Institutes of Health (NIH), and he recently received another five-year renewal of this grant for $2 million.
John Clarke is part of the Gastroenterology & Hepatology Division at Stanford University as Director of the Esophageal Program. He previously spent 17 years in Baltimore, including 9 years on the faculty at Johns Hopkins University where he was an Associate Professor and at various times Director of Esophageal Motility, Director of Gastrointestinal Motility, Clinical Director of the Johns Hopkins Center for Neurogastroenterology, and Clinical Director of the Gastroenterology & Hepatology Division at Johns Hopkins Bayview Medical Center.
His career has combined research, education and clinical care. His clinical areas of expertise include achalasia, dysphagia, eosinophilic esophagitis, esophageal dysmotility, gastroesophageal reflux disease, gastroparesis, GI-manifestations of scleroderma and GI dysmotility. While at Johns Hopkins University, he was inducted into The Miller-Coulson Academy for Clinical Excellence, an institutional honor society for master clinicians at the time limited to 50 members across the entire university.
From an education standpoint, he has lectured in over a dozen countries, authored over 25 textbook chapters and serves on the educational affairs committee of the American College of Gastroenterology. He has also won several major teaching awards, including The Johns Hopkins University Alumni Association Award for Excellence in Teaching, given to one faculty member per year in the entire School of Medicine.
His research has focused on optimization and characterization of diagnostic studies to evaluate motility disorders, as well the relationship between therapeutic endoscopic techniques and treatment of motility disorders. He was an investigator on the NIH Gastroparesis Consortium and is also a former recipient of the AGA Don Castell Award.
Henry Parkman is the Vice Chair of Research, Department of Medicine Professor and Medicine Director at the GI Motility Laboratory at the Lewis Katz School of Medicine. His main areas of research include the use of multichannel electrogastrography to assess gastric myoelectrical activity to detect gastric motor function in patients with dyspeptic symptoms. He has developed a noninvasive test to measure simultaneously both gastric emptying and gastric volume after ingestion of a solid meal under physiologic conditions which is useful in defining the pathophysiologic factors which cause symptoms in patients with functional dyspepsia and be useful to test the effects of new pharmaceutical agents. He is also investigating gastric motility, breath tests for gastric emptying, electrogastrography (EGG), new pharmaceutical treatments for gastroparesis and functional dyspepsia, small bowel motility recordings, esophageal pH and motility recordings.
Dr. Kuo is Assistant Professor of Medicine at Massachusettes General Hospital. His laboratory is focused on clinical and translational research in GI Motility and Visceral Pain Syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome. The research has several components including research into gut motility physiology in health and disease, understanding the brain circuitry of gut sensations, and clinical trials.