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Cervical Cancer - Pipeline Insight, 2020

  • ID: 4989128
  • Drug Pipelines
  • October 2020
  • Region: Global
  • 105 pages
  • DelveInsight

FEATURED COMPANIES

  • Advaxis
  • AstraZeneca
  • Biocad
  • Regeneron Pharmaceuticals
  • Sanofi
  • Zeria Pharmaceutical
This “Cervical Cancer - Pipeline Insight, 2020” report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in Cervical Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Cervical Cancer Understanding

Cervical Cancer: Overview

Cervical cancer starts in the cells lining the cervix -- the lower part of the uterus (womb). The cervix connects the body of the uterus (the upper part where a fetus grows) to the vagina (birth canal). Cancer starts when cells in the body begin to grow out of control. The cervix is made of two parts and is covered with two different types of cells.
  • The endocervix is the opening of the cervix that leads into the uterus. It is covered with glandular cells.
  • The exocervix (or ectocervix) is the outer part of the cervix that can be seen by the doctor during a speculum exam. It is covered in squamous cells.
The place where these two cell types meet in the cervix is called the transformation zone. The exact location of the transformation zone changes as you get older and if you give birth. Most cervical cancers begin in the cells in the transformation zone.

Symptoms

The most common symptoms of cervical cancer are:
  • bleeding between periods
  • bleeding after sexual intercourse
  • bleeding in post-menopausal women
  • discomfort during sexual intercourse
  • vaginal discharge with a strong odor
  • vaginal discharge tinged with blood
  • pelvic pain
Diagnosis

Diagnostic process may include the following tests:
  • A pelvic exam (which may include a rectal exam) - An examination in which health care professional checks the uterus, ovaries, and other organs near the cervix
  • Cystoscopy - A test in which the inside of the urethra and bladder are studied with a lighted device
  • Colonoscopy - A test in which the entire colon is examined with a slender, lighted instrument called a colonoscope
Treatment

Cervical cancer treatment options include surgery, radiotherapy, chemotherapy, or combinations of these. Deciding on the kind of treatment depends on several factors, such as the stage of the cancer, as well as age and overall state of health. Treatment for early-stage cervical cancer, when the cancer remains within the cervix, has a good success rate. The further a cancer spreads from its original area, the lower the success rate tends to be.

Cervical Cancer Emerging Drugs Chapters

This segment of the Cervical Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Cervical Cancer Emerging Drugs

Z 100: Zeria

Zeria is conducting a phase III randomized, double-blind, placebo-controlled trial of Z-100 plus radiation therapy in patients with locally advanced cervical cancer. This study is a phase III, multicenter, double-blind, placebo-controlled, parallel group comparative study to evaluate the efficacy and safety of Z-100 with primary uterine cervical cancer on radiotherapy. The study will use a central randomization with a dynamic allocation using biased coin minimization.

Axalimogene filolisbac: Advaxis, Inc.

Axalimogene filolisbac is a type of cancer vaccine being developed as immunotherapy that attacks HPV-associated cancers such as cervical cancers. It works by alerting the body’s immune system to the presence of cancer, stimulating the body’s natural defenses to attack the cancer. Axalimogene filolisbac is given intravenously and is being developed for the treatment of persistent, recurrent, or metastatic, squamous or non-squamous cell cervical cancer in patients who progress beyond first-line therapy. If licensed, Axalimogene filolisbac will offer a new treatment option for this patient group.

Cervical Cancer: Therapeutic Assessment

This segment of the report provides insights about the different Cervical Cancer drugs segregated based on following parameters that define the scope of the report.

Major Players in Cervical Cancer

There are approx. 50+ key companies which are developing the therapies for Cervical Cancer. The companies which have their Cervical Cancer drug candidates in the mid to advanced stage, i.e. phase III and Phase II include, El Kendi Pharmaceuticals Manufacturing Company, Zeria Pharmaceutical, Advaxis, Biocad, AstraZeneca, Regeneron Pharmaceuticals, Sanofi, Shanghai Bovax Biotechnology Co., Ltd. etc.

Phases

This report covers around 50+ products under different phases of clinical development like
  • Mid-stage products (Phase II and Phase I/II)
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Cervical Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Subcutaneous
  • Intravenous
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Immunoglobulin Fc fragments
  • Monoclonal antibodies
  • Immunoglobulins
  • Immunoproteins
  • Serum globulins
  • Small molecules
  • Stem cell therapies
  • Immunotherapies
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Cervical Cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Cervical Cancer therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Cervical Cancer drugs.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Cervical Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Cervical Cancer.
  • September 2020: Agenus Presents Results from Two Large Cervical Cancer Trials at ESMO
  • 160 patient balstilimab (PD-1) monotherapy trial achieves response rates of 14% in all treated patients and 19% in PD-L1 positive patients
  • 155 patient balstilimab (PD-1) + zalifrelimab (CTLA-4) combination trial achieves response rates of 22% in all patients and 27% in PD-L1 positive patients
Cervical Cancer Report Insights
  • Cervical Cancer Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Cervical Cancer Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Cervical Cancer drugs?
  • How many Cervical Cancer drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Cervical Cancer?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Cervical Cancer therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Cervical Cancer and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • El Kendi Pharmaceuticals Manufacturing Company
  • Zeria Pharmaceutical
  • Advaxis
  • Biocad
  • AstraZeneca
  • Regeneron Pharmaceuticals
  • Sanofi
  • Shanghai Bovax Biotechnology Co., Ltd.
Key Products
  • Cemiplimab
  • BCD-100
  • Z-100
  • ADXS11-001
  • V501

This report will be delivered within 1-3 business days.
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • Advaxis
  • AstraZeneca
  • Biocad
  • Regeneron Pharmaceuticals
  • Sanofi
  • Zeria Pharmaceutical
Introduction

Executive Summary

Cervical Cancer: Overview
  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management
Pipeline Therapeutics
  • Comparative Analysis
Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type
Cervical Cancer - Analytical Perspective

In-depth Commercial Assessment
  • Cervical Cancer companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Cervical Cancer Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
  • Comparative Analysis
Cemiplimab: Regeneron Pharmaceuticals
  • Product Description
  • Research and Development
  • Product Development Activities
Mid Stage Products (Phase II)
  • Comparative Analysis
AK104: Akeso
  • Product Description
  • Research and Development
  • Product Development Activities
GB226: Genor Biopharma Co., Ltd.
  • Product Description
  • Research and Development
  • Product Development Activities
Pre-clinical and Discovery Stage Products
  • Comparative Analysis
FlowVax HPV: Flow Pharma
  • Product Description
  • Research and Development
  • Product Development Activities
Inactive Products
  • Comparative Analysis
Cervical Cancer Key Companies

Cervical Cancer Key Products

Cervical Cancer- Unmet Needs

Cervical Cancer- Market Drivers and Barriers

Cervical Cancer- Future Perspectives and Conclusion

Cervical Cancer Analyst Views

Cervical Cancer Key Companies

Appendix

List of Tables
Table 1 Total Products for Cervical Cancer
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List of Figures
Figure 1 Total Products for Cervical Cancer
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Note: Product cover images may vary from those shown
  • El Kendi Pharmaceuticals Manufacturing Company
  • Zeria Pharmaceutical
  • Advaxis
  • Biocad
  • AstraZeneca
  • Regeneron Pharmaceuticals
  • Sanofi
  • Shanghai Bovax Biotechnology Co., Ltd
Note: Product cover images may vary from those shown
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