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Isocitrate Dehydrogenase (IDH) Inhibitors - Competitive Landscape, Market and Pipeline Analysis, 2020

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    Drug Pipelines

  • 100 Pages
  • March 2020
  • Region: Global
  • DelveInsight
  • ID: 4997184

Isocitrate dehydrogenase (IDH) is an enzyme which catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (a-ketoglutarate) and CO2. Isocitrate dehydrogenase (IDH) inhibitors are developed as therapeutics targeting IDH mutation in cancers. On the basis of kinetic and structural studies, it has been suggested that IDH inhibitors are either capable of binding to the a-KG/isocitrate site and consequently act as binding competitors. Alternatively, they may also bind allosterically to the interface between the two promoters of the IDH enzyme molecule dimer.

“Isocitrate Dehydrogenase (IDH) inhibitors - Competitive Landscape, Market and Pipeline Analysis, 2020” report provides comprehensive insights on the therapeutic development for this mechanism of action. The objective of the report is to establish an understanding of the therapeutic competitive landscape for Isocitrate Dehydrogenase inhibitors (IDH inhibitors), including the marketed and pipeline products in this space. This report provides detailed information on marketed products with historical and forecasted sales till 2030. It further offers comparative pipeline analysis with their drug profiles at various stages of development covering Phase III, Phase II, Phase I, Preclinical and Discovery. Information on company collaborations, agreements, acquisitions, licensing, deals, and other development activities is also involved in this report. Therapeutics assessment of active pipeline drugs by stage, therapy type, route of administration, and molecule type is also covered in this report. It features the inactive pipeline products and highlights currently undergoing institutional research in this area. The report provides the understanding of the unmet needs, market drivers and barriers of the Isocitrate Dehydrogenase inhibitors market.

Future competitive landscape of Isocitrate Dehydrogenase (IDH) inhibitors is estimated to be very strong. Key emerging drugs including Agios Pharmaceuticals' AG-120 (Ivosidenib) and others are going to be Blockbuster in the upcoming years.

This report on Isocitrate Dehydrogenase (IDH) inhibitors help companies in understanding market dynamics based on this mechanism of action and therefore giving opportunities for a strategic alliance that will result in market penetration and enhancement of portfolios with optimal investment and maximal return. In addition s will assuage companies to detect conditions, determine genetic predisposition and biological response to Isocitrate Dehydrogenase (IDH) inhibitors.

Isocitrate Dehydrogenase (IDH) inhibitors Report Key Features

The report provides insights into:
  • Detailed market drug profiles available in the market indicated for this mechanism of action with historical and forecasted sales till 2030.
  • A number of companies developing therapies of Isocitrate Dehydrogenase inhibitors (IDH inhibitors) with aggregate therapies developed by each company for the same.
  • Detailed profiles of therapeutic candidates in nonclinical stage, early-stage, mid-stage and late-stage of development for Isocitrate Dehydrogenase inhibitors (IDH inhibitors).
  • Analyses key players involved in Isocitrate Dehydrogenase inhibitors (IDH inhibitors) targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
  • Active pipeline therapies assessment under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
  • Detail analysis of collaboration (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future developments of Isocitrate Dehydrogenase inhibitors (IDH inhibitors).

The report is built using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university web sites and industry-specific third party sources, etc.

Isocitrate Dehydrogenase (IDH) inhibitors Analytical Perspective

In-depth Isocitrate Dehydrogenase (IDH) inhibitors Analysis: Assessment of Products

This report provides an in-depth commercial assessment of therapeutic drugs that have been included, which comprises of collaborations, agreements, licensing, and acquisition - deal value trends. The sub-segmentation is described in the report which provides company-company collaborations (licensing/partnering), company-academia collaborations, and acquisition analysis in both graphical and tabulated form.

Isocitrate Dehydrogenase (IDH) inhibitors Clinical Assessment of Products

The report comprises of comparative clinical assessment of products by development stage, product type, and route of administration, molecule type, and MOA type across this mechanism of action.

Scope of the Report
  • The Isocitrate Dehydrogenase inhibitors report provides an overview of this mechanism of action, role, significance, pathway, types, and clinical application of IDH inhibitors.
  • Therapeutic Assessment: Therapeutic pipeline activity and assessment of the products by development stage, product type, route of administration, molecule type, and MOA the complete product development cycle, including all clinical and nonclinical stages.
  • It comprises of detailed profiles of therapeutic products for Isocitrate Dehydrogenase inhibitors (IDH inhibitors) with key coverage of developmental activities, including collaborations, agreements, licensing, mergers and acquisition, funding, designations, technology and other product-related details.
  • In-depth Isocitrate Dehydrogenase inhibitors research and development progress and trial details results wherever available, are also included in the pipeline study.
  • Coverage of dormant and discontinued pipeline projects along with the reasons if available across Isocitrate Dehydrogenase inhibitors (IDH inhibitors).
  • The report has also covered the worldwide market of Isocitrate Dehydrogenase inhibitors (IDH inhibitors), information of marketed therapies, their historical and forecasted sales till 2030.
  • It also includes patent expiry details impact on market after expiry.
  • Key topics covered include strategic competitor assessment, market characterization, opportunities, unmet needs, market growth factors, barriers and challenges along with SWOT analysis of the Isocitrate Dehydrogenase inhibitors market.
  • Analysis of the current and future market competition in the global Isocitrate Dehydrogenase inhibitors market. Current scenario of the market with upcoming blockbuster molecules and their impact on the overall market.

Report Highlights
  • In the coming years, the Isocitrate Dehydrogenase inhibitors market is set to change due to the extensive research in this filed, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
  • The companies and academics are working to assess challenges and seek opportunities that could influence Isocitrate Dehydrogenase inhibitors R&D. The Isocitrate Dehydrogenase inhibitors therapies under development are focused on novel approaches to treat/improve the disease condition.
  • There are many companies involved in developing therapies for Isocitrate Dehydrogenase inhibitors (IDH inhibitors). Launch of emerging therapies of Isocitrate Dehydrogenase inhibitors (IDH inhibitors) will significantly impact the market.
  • A better understanding of the target mechanism will also contribute to the development of novel therapeutics for Isocitrate Dehydrogenase inhibitors (IDH inhibitors).
  • Our in-depth analysis of the pipeline assets (in early-stage, mid-stage and late-stage of development for the treatment of Isocitrate Dehydrogenase inhibitors (IDH inhibitors) includes therapeutic assessment and comparative analysis. This will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.
  • The report provides the detailed analysis of 8+ products along with 6+ companies involved.

Companies Mentioned
  • Agios Pharmaceuticals
  • Bayer
  • Daiichi Sankyo Company
  • Evotec
  • GlaxoSmithKline
  • Novartis
  • And many more

Key Questions
  • What are Isocitrate Dehydrogenase inhibitors (IDH inhibitors), their role and significance in the treatment of disease conditions?
  • What are the current treatment options based on the Isocitrate Dehydrogenase inhibitors (IDH inhibitors) available in the market?
  • How the historical and forecasted sales of the marketed therapies determine their scenario in the current Isocitrate Dehydrogenase inhibitors market?
  • How many therapies are developed by each company for Isocitrate Dehydrogenase inhibitors (IDH inhibitors) to treat disease conditions?
  • What are the key collaborations (Industry-Industry, Industry-Academia), mergers and acquisitions, licensing activities related to the Isocitrate Dehydrogenase inhibitors therapies?
  • Which are the dormant and discontinued products and the reasons for dormancy and discontinuation?
  • What is the unmet need for current therapies developed on the basis of this mechanism of action?
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Isocitrate Dehydrogenase inhibitors (IDH inhibitors) and their status?

Table of Contents

1. Report Introduction
2. Isocitrate Dehydrogenase (IDH) inhibitors
2.1. Isocitrate Dehydrogenase (IDH) inhibitors Overview
2.2. Isocitrate Dehydrogenase (IDH) inhibitors Types
2.3. Isocitrate Dehydrogenase (IDH) inhibitors Structure
2.4. Isocitrate Dehydrogenase (IDH) inhibitors Mechanism of Action
2.5. Isocitrate Dehydrogenase (IDH) inhibitors Application
3. Competitive Landscape
3.1. Marketed Product Profiles
3.1.1. Idhifa: Celgene Corporation Product Description Research and Development Clinical Studies Other Pipeline Activities Product Development Activities Idhifa Sales
4. Isocitrate Dehydrogenase (IDH) inhibitors - Analytical Perspective
4.1. In-depth Commercial Assessment
4.1.1. Isocitrate Dehydrogenase (IDH) inhibitors Companies Collaborations, Licensing, Acquisition - Deal Value Trends Assessment Summary
4.1.2. Isocitrate Dehydrogenase (IDH) inhibitors Collaboration Deals Company-Company Collaborations (Licensing/Partnering) Analysis Company-University Collaborations (Licensing/Partnering) Analysis Isocitrate Dehydrogenase (IDH) inhibitors Acquisition Analysis
5. Therapeutic Assessment
5.1. Clinical Assessment of Pipeline Drugs
5.1.1. Assessment by Stage of Development
5.1.2. Assessment by Product Type (Mono/Combination) Assessment by Stage and Product Type
5.1.3. Assessment by Route of Administration Assessment by Stage and Route of Administration
5.1.4. Assessment by Molecule Type Assessment by Stage and Molecule Type
5.1.5. Assessment by MOA Assessment by Stage and MOA
5.1.6. Assessment by Target Assessment by Stage and Target
6. Pipeline Therapeutics
6.1. Comparative Analysis
7. Late-Stage Products (Phase-III)8. Mid-Stage Products (Phase-II)9. Early-Stage Products (Phase-I)10. Preclinical and Discovery Stage Products
11. Isocitrate Dehydrogenase (IDH) inhibitors Emerging Drug Profiles
11.1. AG-120: Agios Pharmaceuticals
11.1.1. Product Description
11.1.2. Research and Development Clinical Studies
11.1.3. Product Development Activities
11.1.4. Tabulated Product Summary General Description Table
*Many more drugs with detailed profiles provided in the report
12. Isocitrate Dehydrogenase (IDH) inhibitors Key Companies13. Isocitrate Dehydrogenase (IDH) inhibitors Key Products
14. Inactive Products
14.1. Dormant Products
14.1.1. Reason for Dormancy
14.2. Discontinued Products
14.2.1. Reason for Discontinuation
15. Isocitrate Dehydrogenase (IDH) inhibitors - Unmet Needs16. Isocitrate Dehydrogenase (IDH) inhibitors - Market Drivers and Barriers17. Isocitrate Dehydrogenase (IDH) inhibitors - Future Perspectives and Conclusion18. Isocitrate Dehydrogenase (IDH) inhibitors Analyst Views19. Appendix
20. Report Methodology
20.1. Secondary Research
20.2. Expert Panel Validation

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Agios Pharmaceuticals
  • Bayer
  • Daiichi Sankyo Company
  • Evotec
  • GlaxoSmithKline
  • Novartis