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Annual Reports in Medicinal Chemistry, Vol 54

  • ID: 5007946
  • Book
  • September 2020
  • Region: Global
  • 310 Pages
  • Elsevier Science and Technology
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The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Annual Reports in Medicinal Chemistry series
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1. Challenges in developing quadruplex therapeutics Stephen Neidle 2. Fundamentals of quadruplex biology FB Johnson 3. Quadruplex folding and diversity Anh Tuân Phan 4. Telomeric quadruplexes as therapeutic targets Hiroshi Sugiyama 5. Viral G-quadruplexes: new frontiers in virus pathogenesis and antiviral therapy Sara N. Richter 6. Quadruplex targeting in infective and parasitic diseases Samir Amrane 7. Quadruplex detection in cells David Monchaud 8. An overview of quadruplex ligands: their common features and chemotype diversity Filippo Doria 9. Quadruplex simulations and drug design Jiri Sponer 10. Lead discovery of quadruplex-binding small molecules Marie-Paule Teulade-fichou 11. Click and combinatorial approaches to quadruplex ligand discovery Jyotirmayee Dash 12. Targeting k-RAS quadruplexes Luigi Xodo 13. Targeting MYC by quadruplex approaches John Schneekloth 14. Targeting KIT quadruplexes Claudia Sissi 15. Quadruplex targets in neurodegenerative diseases Janez Plavec 16. Metallo-containing quadruplex ligands Ramon Vilar
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