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COVID-19 Testing: Symptoms, Asymptomatic, and Serology for Immunity

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  • 103 Pages
  • April 2020
  • Region: Global
  • Wintergreen Research, Inc
  • ID: 5011467

This new study describes the United States testing for the rapidly evolving COVID-19 pandemic. Testing capability forecasts for PCR assay and Molecular Diagnostics are presented in two-week increments for the next 6 months. The availability of Serological testing is also forecast for the detection of the virus after recovery. All major vendors are included and can be compared with quantities, qualities, and test time.

COVID-19 Testing 2020: The Way Forward describes the timelines the virus is likely to take regarding quarantines and successive waves of infection. Successive waves of infection are expected to strike the US population after the shelter in place restrictions start to be lifted. Intensive testing is needed at every stage of COVID-19 disease management. The testing scenarios and the vendors with good test kits are described in detail.

Successive waves of infection are expected to continue to at least January 2021. One thing that will stop them is if an effective vaccine is found. The 2020 study has 96 pages, 12 tables, and figures. The tables describe in enormous detail what testing kits are available and the significance of further testing. It describes testing capacity and length of time to administer testing. It describes the impact of testing and the need for serological testing as the quarantines begin to end.

PCR testing - as used by the CDC and WHO initially - is very labor-intensive, and has several points along the path of doing a single test where errors may occur - which may lead to headline issues of a false positive, the test showing evidence of the virus when it's not actually there, or a false negative, suggesting someone doesn't have the virus when in fact they do.

The virus and the resulting disease, COVID-19, have hit Germany with force: According to Johns Hopkins University, the country had more than 91,000 laboratory-confirmed infections by Saturday morning, more than any other country except the United States, Italy, and Spain. But with 1,275 deaths, Germany's fatality rate stood at 1.3 percent, compared with 12 percent in Italy, around 10 percent in Spain, France, and Britain, 4 percent in China and 2.5 percent in the United States. Even South Korea, a model of flattening the curve, has a higher fatality rate, 1.7 percent.

When the first cases of COVID-19 were reported in the US, two labs at the CDC were the only ones permitted to conduct COVID-19 testing, using a test developed by the agency's own researchers. When the CDC tried to expand testing by providing its test kits to state and local public health labs, there were problems with the initial version of the kits, The CDC, despite initially faulty reagents making its first test kits unreliable, is now offering accurate RT-PCR Diagnostic Panels and positive and human specimen controls.

“Had (the US) done more testing from the very beginning and caught cases earlier,” said Dr. Nuzzo, of Johns Hopkins, “we would be in a far different place.

Key Topics:

  • Coronavirus
  • COVID-19
  • SARS Testing
  • Patient Testing 2020
  • Symptoms Testing
  • Asymptomatic Testing
  • Serology for Testing Immunity

Table of Contents

1. US COVID-19 Testing - CDC and Vendor Ability to Provide Tests
1.1 COVID-19 PCR Testing Market Driving Forces
1.2 COVID-19 Testing
1.3 COVID-19 Testing Equipment Missed the Mark
1.3.1 COVID-19 Need for Quarantine
1.3.2 Viral Load
1.3.3 COVID-19 Testing on Patients with Symptoms
1.3.4 COVID-19 Serological Contact Testing
1.3.5 COVID-19 Serological Testing on Social Contacts of Patients with Symptoms
1.4 COVID-19 Testing Prices
2. Delays in the US COVID-19 Testing and International Response
2.1 Broader Testing Delayed
2.2 Government and Open Market Control of Testing
2.3 Extracting Virus from Blood Sample
3. COVID-19 Testing Regional Analysis
3.1 COVID-19 Number People Affected Worldwide
3.2 US
3.3 China
3.4 India
3.5 Europe
3.6 Asia
3.7 Rest of World
4. COVID-19 Molecular Diagnostics Testing Technology
4.1 Coronavirus Assay Testing Technique Polymerase Chain Reaction (PCR)
4.2 Panther Fusion Automates The Complex Steps Involved In Molecular Diagnostics COVID-19 Testing
4.2.1 Molecular Diagnostics
4.3 Scientists Need The Actual Virus In Order To Check A Diagnostic Test
5. COVID-19 Testing Equipment Company Profiles
5.1 Abbott Laboratories
5.2 Alphabet Verify
5.3 Astrotech
5.4 Beckman Coulter
5.5 Bill Gates
5.6 bioMérieux
5.7 Bodysphere
5.8 Center for Disease Control and Prevention CDC
5.8.1 CDC Serology Test for SARS-CoV-2
5.9 Co-Diagnostics, Inc.
5.10 Danaher
5.10.1 Cepheid is part of Danaher (NYSE: DHR).
5.10.2 Cepheid
5.10.3 Danaher / Integrated DNA Technologies (IDT)
5.11 US FDA
5.12 GenMark Diagnostics
5.13 Hologic
5.14 Hong Kong University of Science and Technology (HKUST)
5.15 LabCorp
5.15.1 LabCorp Testing
5.16 Logix Smart
5.17 Mammoth Biosciences
5.18 Opko / BioReference Laboratories
5.18.1 OPKO Health
5.19 Quidel
5.20 Quest Diagnostics
5.20.1 Quest / Roche Partnership
5.20.2 Roche IVD test / Quest Diagnostics LDT
5.21 Roche Diagnostics
5.21.1 Roche IVD Test for COVID-19 Offered by Quest Diagnostics
5.22 Sherlock Biosciences
5.23 SunSure Biotech
5.24 Tianjin University China
5.25 Thermo Fisher Scientific
5.25.1 Thermo Fisher Scientific / Applied Biosystems
5.25.2 Thermo Fisher / Dutch Diagnostics Firm Qiagen
5.26 Tianjin University of China
5.27 Where to Look for More COVID-19 Information
6. COVID-19 PCR Testing: Description and Dynamics
6.1 Rapidly Evolving COVID-19
6.2 COVID-19 a Respiratory Illness
6.2.1 COVID-19 Symptoms
6.2.2 Diagnostic Testing for COVID-19
6.2.3 Guidance for Testing
6.2.4 COVID-19 Quarantine
6.3 PCR and Molecular Diagnostic Testing Status
6.4 Where to Get Tested
6.5 Testing: False Negative and False Positive
6.6 Serology Testing for COVID-19
List of Figures
Figure 1. US COVID-19 Serological Testing to see if a Person Has Already Had the Corona Virus and Does Not Need to Be Put in Quarantine, April 1, 2020, to September 1, 2020 Capability Forecasts by Two Week Intervals
Figure 2. US Serological Testing on People Who Have Been in Contact with COVID-19 Patients with Symptoms, May 1 to October 1, 2020
Figure 3. COVID-19 US Testing Market Driving Forces
Figure 4. COVID-19 Testing for Quarantine Implementation
Figure 5. CDC and Vendor implementation of COVID-19 Testing
Figure 6. Testing in the Next Phase of COVID-19 Outbreak: Suppression
Figure 7. COVID-19 Characteristics Impacted by Testing
Figure 8. Testing Characteristics Impacting COVID-19 Healthcare Management
Figure 9. COVID-19 Testing Initially Quarantined Population Management Timelines
Figure 10. COVID-19 Testing Second Wave Quarantined Population Management Timelines
Figure 11. Impact on Testing of Waves of Critically Ill Patients with COVID-19
Figure 12. US COVID-19 Testing Equipment Market Share Description, Number of Tests Day, Tests per Week Capability, Time to Administer, April 1, 2020
Figure 13. US COVID-19 Testing Equipment Company Description, Number of Tests per Day, Tests per Week Capability, April 1, 2020, Time to Administer, April 1, 2020
Figure 14. US COVID-19 Patient with Symptom Testing Capability April 1, 2020, to September 1, 2020 Forecasts by Two Week Intervals, Testing Patients Who Present Symptoms at Care Facility or Hospital
Figure 15. US Serological Testing on People Who Have Been in Contact with COVID-19 Patients with Symptoms, May 1 to October 1, 2020
Figure 16. Abbott Virus Detection Machine
Figure 17. GenMark Diagnostics Coronavirus ePlex Testing System
Figure 18. Hologic’s Panther Fusion® SARS-CoV-2 test
Figure 19. Quest Healthcare Provider Fact Sheet
Figure 20. Governor Cuomo - The Face of COVID-19 Resistance

Companies Mentioned

A selection of companies mentioned in this report includes:

  • Abbott Laboratories
  • Alphabet Verify
  • Applied Biosystems
  • Astrotech
  • Beckman Coulter
  • bioMérieux
  • BioReference Laboratories
  • Bodysphere
  • Center for Disease Control and Prevention (CDC)
  • Cepheid
  • Co-Diagnostics, Inc.
  • Danaher
  • GenMark Diagnostics
  • Hologic
  • Hong Kong University of Science and Technology (HKUST)
  • Integrated DNA Technologies (IDT)
  • LabCorp
  • Logix Smart
  • Mammoth Biosciences
  • Opko
  • Qiagen
  • Quest Diagnostics
  • Quidel
  • Roche
  • Sherlock Biosciences
  • SunSure Biotech
  • Thermo Fisher Scientific
  • Tianjin University China
  • US FDA