Imaging mass spectrometry (MS) techniques are often utilized without an understanding of their underlying principles, making it difficult for scientists to determine when and how they can exploit MS to visualize their biomolecules of interest. Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry is an essential reference to help scientists determine the status and strategies of biomolecule analysis, describing its many applications for diverse classes of biomolecules.
The book builds a foundation of imaging MS knowledge by introducing ionization sources, sample preparation, visualization guidelines, molecule identification, quantification, data analysis, etc. The second section contains chapters focused on case studies on analyzing a biomolecule class of molecules. Case studies include an introduction/background, and a summary of successful imaging MS studies with illustrative figures and future directions.
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Table of Contents
1. Fundamentals of Imaging Mass Spectrometry2. Ionization Source for Imaging Mass Spectrometry3. Sample Preparation and MALDI Matrix Applications4. Tissue Sectioning for Imaging Mass Spectrometry5. Matrix for Matrix-assisted Laser Desorption/Ionization (MALDI)6. Molecule Identification Approaches in Imaging Mass Spectrometry7. Quantitation Workflow in Imaging Mass Spectrometry8. Spatial Resolution of Imaging Mass Spectrometry9. Visualization of Imaging Mass Spectrometry10. Analysis of imaging mass spectrometry data11. Multimodal imaging mass spectrometry12. Validation and Standardization of Imaging Mass Spectrometry13. Towards Clinical Imaging Mass Spectrometry14. Case study: Imaging N-Glycan on tissue15. Case study: Reactive matrix and neurotransmitters and brain metabolites16. Case study: Endogenous metabolites in mammalian tissues17. Case study: Imaging of small drug molecules18. Case study: Imaging Gangliosides
