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Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry

  • Book
  • April 2021
  • Elsevier Science and Technology
  • ID: 5029549

Imaging mass spectrometry (MS) techniques are often utilized without an understanding of their underlying principles, making it difficult for scientists to determine when and how they can exploit MS to visualize their biomolecules of interest. Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry is an essential reference to help scientists determine the status and strategies of biomolecule analysis, describing its many applications for diverse classes of biomolecules.

The book builds a foundation of imaging MS knowledge by introducing ionization sources, sample preparation, visualization guidelines, molecule identification, quantification, data analysis, etc. The second section contains chapters focused on case studies on analyzing a biomolecule class of molecules. Case studies include an introduction/background, and a summary of successful imaging MS studies with illustrative figures and future directions.

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Table of Contents

1. Fundamentals of Imaging Mass Spectrometry 2. Ionization Source for Imaging Mass Spectrometry 3. Sample Preparation and MALDI Matrix Applications 4. Tissue Sectioning for Imaging Mass Spectrometry 5. Matrix for Matrix-assisted Laser Desorption/Ionization (MALDI) 6. Molecule Identification Approaches in Imaging Mass Spectrometry 7. Quantitation Workflow in Imaging Mass Spectrometry 8. Spatial Resolution of Imaging Mass Spectrometry 9. Visualization of Imaging Mass Spectrometry 10. Analysis of imaging mass spectrometry data 11. Multimodal imaging mass spectrometry 12. Validation and Standardization of Imaging Mass Spectrometry 13. Towards Clinical Imaging Mass Spectrometry 14. Case study: Imaging N-Glycan on tissue 15. Case study: Reactive matrix and neurotransmitters and brain metabolites 16. Case study: Endogenous metabolites in mammalian tissues 17. Case study: Imaging of small drug molecules 18. Case study: Imaging Gangliosides


Bindesh Shrestha Senior Application Support Scientist, Waters Corporation, Beverly, MA, USA. Dr. Bindesh Shrestha is a senior scientist at the Waters Corporation focusing on imaging mass spectrometry. He has co-authored more than two dozen peer-reviewed articles in the field of mass spectrometry spanning over the last decade. His publications have been featured multiple times on the covers of leading journals, including Angewandte Chemie, Analytical Chemistry, Analyst, and more.