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Cell Free Protein Expression - Global Market Trajectory & Analytics

  • ID: 5029789
  • Report
  • June 2021
  • Region: Global
  • 121 pages
  • Global Industry Analysts, Inc

FEATURED COMPANIES

  • Biotechrabbit GmbH
  • Creative Biolabs, Inc.
  • Cube Biotech GmbH
  • GeneCopoeia, Inc.
  • Jena Bioscience GmbH
  • Merck KGaA
  • MORE

Global Cell Free Protein Expression Market to Reach $271.6 Million by 2026


Cell-free Protein Expression is basically a technique enabling mostly researchers to rapidly express as well as manufacture functional proteins in small amounts. When compared to approaches that are in vivo and which are based on tissue culture or bacterial cells, cell-free protein expression is faster as it does not necessitate cell culture, gene transfection or protein purification at an extensive level. As protein synthesis happens in cell lysates and not inside cultured cells, it is also referred to as cell-free protein expression. Other names for the approach are cell-free translation, cell-free protein synthesis and in vitro translation. Production of cell-free protein can be done using different species and kinds of cell extracts. The different approaches offer many advantages complementing conventional in vivo methodologies. Cell-free protein expression is ideal for experiments meant for characterizing protein-protein interactions and protein-nucleic acid interactions and for high-throughput and rapid expression of truncated or mutant proteins for the purpose of functional analysis. Another application for which the approach is considered ideal is mammalian protein expression with appropriate glycosylation and native PTMs (Post-translational Modifications). The technique is also being increasingly used for stable isotopes containing proteins labelling, for the purpose of structural analysis and for the production of toxic polypeptides and functional virons. Researchers also use cell-free protein expression for analysing components needed for protein stability, degradation and folding.

Amid the COVID-19 crisis, the global market for Cell Free Protein Expression estimated at US$195.4 Million in the year 2020, is projected to reach a revised size of US$271.6 Million by 2026, growing at a CAGR of 5.7% over the analysis period. Protein-Protein Interaction, one of the segments analyzed in the report, is projected to grow at a 6.3% CAGR to reach US$147.9 Million by the end of the analysis period. After a thorough analysis of the business implications of the pandemic and its induced economic crisis, growth in the Protein Labeling segment is readjusted to a revised 4.8% CAGR for the next 7-year period. This segment currently accounts for a 24.1% share of the global Cell Free Protein Expression market.

The U.S. Market is Estimated at $105.2 Million in 2021, China is Forecast to Reach $25.7 Million by 2026


The Cell Free Protein Expression market in the U.S. is estimated at US$105.2 Million in the year 2021. The country currently accounts for a 51.51% share in the global market. China, the world second largest economy, is forecast to reach an estimated market size of US$25.7 Million in the year 2026 trailing a CAGR of 7.5% through the analysis period. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 4.6% and 5% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 5.7% CAGR while Rest of European market (as defined in the study) will reach US$27.7 Million by the close of the analysis period.

Several pharmaceutical companies have in the recent years started research in the protein expression domain. Several biotech companies have also recently started initiatives which necessitate extensive use of cell-free protein expression, which is anticipated to provide the required impetus to market growth at the global level. The biological sector is also trying to use swifter and more agile protein synthesis methods further enhancing market growth dynamics. Furthermore, technology advancements of over the years resulted in use of new expression elements like specially designed promoters exhibiting more efficient genomic engineering and translation leading to improved translation efficiency. There are also now software controlled algorithms facilitating better yield. Other growth factors include increasing outsourcing of R&D by biotechnological and pharmaceutical companies, patent cliff sales reduction resulting in increased pharmaceutical sector research intensity, declining research productivity, and growing expenditure on development of biosimilars. Advanced applications and increasing demand for more efficient and simpler methods for protein production also promote market growth. Different applications for cell-free protein expression include enzyme engineering, protein-protein interaction, protein purification and protein labelling, with the application of protein-protein interactions accounting for the largest percentage in overall market revenues at the global level owing to strong R&D initiatives for generation of protein libraries.

Enzyme Engineering Segment to Reach $41.7 Million by 2026


In the global Enzyme Engineering segment, USA, Canada, Japan, China and Europe will drive the 5.4% CAGR estimated for this segment. These regional markets accounting for a combined market size of US$27 Million in the year 2020 will reach a projected size of US$39 Million by the close of the analysis period. China will remain among the fastest growing in this cluster of regional markets. Led by countries such as Australia, India, and South Korea, the market in Asia-Pacific is forecast to reach US$3 Million by the year 2026.

Select Competitors (Total 34 Featured) -

  • Biotechrabbit GmbH
  • CellFree Sciences Co., Ltd.
  • Creative Biolabs, Inc.
  • Cube Biotech GmbH
  • GeneCopoeia, Inc.
  • Jena Bioscience GmbH
  • Merck KGaA
  • Promega Corporation
  • Takara Bio Inc.
  • Thermo Fisher Scientific Inc.
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • Biotechrabbit GmbH
  • Creative Biolabs, Inc.
  • Cube Biotech GmbH
  • GeneCopoeia, Inc.
  • Jena Bioscience GmbH
  • Merck KGaA
  • MORE
I. METHODOLOGY

II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW
  • A Prelude to Cell Free Protein Expression
  • Impact of Covid-19 and a Looming Global Recession
  • 2020 Marked as a Year of Disruption & Transformation
  • Exhibit 1: World Economic Growth Projections (Real GDP, Annual % Change) for 2020 through 2022
  • COVID-19 Impact on Cell Free Protein Expression Market
  • GLOBAL MARKET OVERVIEW AND PROSPECTS
  • Global Market for Cell-free Protein Expression Set to Witness Rapid Growth
  • Protein-Protein Interactions: Major Market Segment
  • E. coli lysates: Most Commonly Used Lysate Systems
  • Mammalian Systems: A Focul Area of Interest
  • Select Available Mammalian Protein Expression Systems
  • US Dominates the Cell-free Protein Identification Market
  • Competition
  • Recent Market Activity
2. FOCUS ON SELECT PLAYERS

3. MARKET TRENDS & DRIVERS
  • Key advantages Over Traditional Methods Drives the Protein Expression Market Growth
  • Cell-free Protein Synthesis - A Key Tool for Basic and Applied Science
  • Applications of Cell-Free Protein Synthesis
  • Cell-free Protein Synthesis in High-Throughput Production
  • Technological Advancements in Cell Free Protein Extraction Drive Market Prospects
  • Increased Demand for Cell-Free Protein Expression by Biotechnology Firms
  • Growth in number of Pharmaceutical Companies Involved in Protein Expression
  • Exhibit 2: Pharmaceutical R&D Spending Worldwide (USD Billion): 2015-2025
  • Increasing Demand from Microbiology for Better Protein Expression to Propel Market Growth
  • Rising Incidence of Cancer and the Demand for Biologics Spur the Adoption of Cell Free Protein Extraction
  • Exhibit 3: Breakdown of Total Number of Cancer Cases by Type: 2020
  • Exhibit 4: Global Cancer Incidence: Number of New Cancer Cases in Million for the Years 2018, 2020, 2025, 2030, 2035 and 2040
  • Rise in New and Advanced applications of Cell Free Protein Expression
  • Growth in Use of Lysates to Produce Desired Recombinant Proteins Buoys Growth Prospects
  • Rise in Chronic and Infectious Diseases and Need for High-Throughput Diagnosis Drive Interest in Cell-Free Protein Extraction
  • Exhibit 5: Infection Rates of Viruses ((per infected person)) Involved in Outbreaks Worldwide: 2020
  • Exhibit 6: Infectious Diseases Related Mortality High Among Children below 5 Years: Breakdown of Leading Causes of Death in Children below 5 Years (in %)
  • Exhibit 7: Global Number of Deaths Caused Due to Communicable Diseases (In 000s)
  • Growing Preference for Personalized Medicine to Drive Market Growth
  • Exhibit 8: Global Personalized Medicine Market: Revenues in US$ Million for the Years 2019, 2021, 2023 and 2025
  • Rapidly Growing Geriatric Population and the Rise in Associated Diseases Drive the Need for Cell-free Protein Extraction
  • Exhibit 9: Global Population Statistics for the 65+ Age Group in Million by Geographic Region for the Years 2019, 2025, 2035 and 2050
4. GLOBAL MARKET PERSPECTIVE
  • TABLE 1: World Current & Future Analysis for Cell Free Protein Expression by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027 and % CAGR
  • TABLE 2: World Historic Review for Cell Free Protein Expression by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 3: World 15-Year Perspective for Cell Free Protein Expression by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets for Years 2012, 2020 & 2027
  • TABLE 4: World Current & Future Analysis for Protein-Protein Interaction by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027 and % CAGR
  • TABLE 5: World Historic Review for Protein-Protein Interaction by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 6: World 15-Year Perspective for Protein-Protein Interaction by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027
  • TABLE 7: World Current & Future Analysis for Protein Labeling by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027 and % CAGR
  • TABLE 8: World Historic Review for Protein Labeling by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 9: World 15-Year Perspective for Protein Labeling by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027
  • TABLE 10: World Current & Future Analysis for Enzyme Engineering by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027 and % CAGR
  • TABLE 11: World Historic Review for Enzyme Engineering by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 12: World 15-Year Perspective for Enzyme Engineering by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027
  • TABLE 13: World Current & Future Analysis for Protein Purification by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027 and % CAGR
  • TABLE 14: World Historic Review for Protein Purification by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 15: World 15-Year Perspective for Protein Purification by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027
III. MARKET ANALYSIS

UNITED STATES
  • TABLE 16: USA Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 17: USA Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 18: USA 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
CANADA
  • TABLE 19: Canada Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 20: Canada Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 21: Canada 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
JAPAN
  • TABLE 22: Japan Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 23: Japan Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 24: Japan 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
CHINA
  • TABLE 25: China Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 26: China Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 27: China 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
EUROPE
  • TABLE 28: Europe Current & Future Analysis for Cell Free Protein Expression by Geographic Region - France, Germany, Italy, UK and Rest of Europe Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027 and % CAGR
  • TABLE 29: Europe Historic Review for Cell Free Protein Expression by Geographic Region - France, Germany, Italy, UK and Rest of Europe Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 30: Europe 15-Year Perspective for Cell Free Protein Expression by Geographic Region - Percentage Breakdown of Value Sales for France, Germany, Italy, UK and Rest of Europe Markets for Years 2012, 2020 & 2027
  • TABLE 31: Europe Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 32: Europe Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 33: Europe 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
FRANCE
  • TABLE 34: France Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 35: France Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 36: France 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
GERMANY
  • TABLE 37: Germany Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 38: Germany Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 39: Germany 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
ITALY
  • TABLE 40: Italy Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 41: Italy Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 42: Italy 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
UNITED KINGDOM
  • TABLE 43: UK Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 44: UK Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 45: UK 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
REST OF EUROPE
  • TABLE 46: Rest of Europe Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 47: Rest of Europe Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 48: Rest of Europe 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
ASIA-PACIFIC
  • TABLE 49: Asia-Pacific Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 50: Asia-Pacific Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 51: Asia-Pacific 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
REST OF WORLD
  • TABLE 52: Rest of World Current & Future Analysis for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027 and % CAGR
  • TABLE 53: Rest of World Historic Review for Cell Free Protein Expression by Application - Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019 and % CAGR
  • TABLE 54: Rest of World 15-Year Perspective for Cell Free Protein Expression by Application - Percentage Breakdown of Value Sales for Protein-Protein Interaction, Protein Labeling, Enzyme Engineering and Protein Purification for the Years 2012, 2020 & 2027
IV. COMPETITION
  • Total Companies Profiled: 34
Note: Product cover images may vary from those shown

A selection of companies mentioned in this report includes:

  • Biotechrabbit GmbH
  • CellFree Sciences Co., Ltd.
  • Creative Biolabs, Inc.
  • Cube Biotech GmbH
  • GeneCopoeia, Inc.
  • Jena Bioscience GmbH
  • Merck KGaA
  • Promega Corporation
  • Takara Bio Inc.
  • Thermo Fisher Scientific Inc.
Note: Product cover images may vary from those shown
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