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Refractory Angina (RA) - Epidemiology Forecast to 2030

  • ID: 5031259
  • Report
  • May 2020
  • Region: Global
  • 100 pages
  • DelveInsight
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This report delivers an in-depth understanding of the disease, historical and forecasted Refractory Angina epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

Refractory Angina (RA) Understanding

Refractory Angina (RA) is a debilitating chronic condition marked by persistent angina due to reversible myocardial ischemia owing to partial or complete blockage of the blood flow through myocardium (heart muscle) by a buildup of plaques. It is a common reoccurring form of angina resulting from an imbalance between oxygen supply and demand, which encompasses neurological, psychogenic and mitochondrial dysfunctions that, in addition to tissue ischemia, are responsible for persistent cardiac pain syndrome. It is usually reflected in patients with coronary artery disease (CAD) which cannot be adequately controlled by a combination of medical therapy, angioplasty, or coronary artery bypass grafting.

Refractory Angina Epidemiology Perspective

The Refractory Angina epidemiology division provides the insights about historical and current patient pool and forecasted trend for each seven major countries. The Refractory Angina epidemiology data are studied through all possible division to give a better understanding of the Disease scenario in 7MM. The Refractory Angina epidemiology is segmented by Refractory Angina Total Diagnosed Cases of CAD and RA, Refractory Angina Sub-Type Specific Cases, Refractory Angina Gender-Specific Cases and Diagnosed Population of NORDA covering the US, EU5 countries (Germany, Spain, Italy, France, and the UK) and Japan from 2017 to 2030. It also helps to recognize the causes of current and forecasted trends by exploring numerous studies, survey reports and views of key opinion leaders.

Refractory Angina Detailed Epidemiology Segmentation

The Refractory Angina epidemiology covered in the report provides historical as well as forecasted epidemiology {Total Diagnosed Cases of CAD and RA, Sub-Type Specific Cases, Gender-Specific Cases and Diagnosed Population of No-Option Refractory Disabling Angina (NORDA)} scenario of Refractory Angina in the 7MM covering United States, EU5 countries (Germany, Spain, Italy, France and United Kingdom) and Japan from 2017 to 2030.

The Refractory Angina report also provides the epidemiology trends observed in the 7MM during the study period, along with the assumptions undertaken. The calculated data are presented with relevant tables and graphs to give a clear view of the epidemiology at first sight.

Scope of the Report
  • The Refractory Angina report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis and treatment patterns
  • The Refractory Angina Epidemiology Report and Model provide an overview of the risk factors and global trends of Refractory Angina in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan)
  • The report provides insight about the historical and forecasted patient pool of Refractory Angina in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK) and Japan
  • The report helps to recognize the growth opportunities in the 7MM with respect to the patient population
  • The report assesses the disease risk and burden and highlights the unmet needs of Refractory Angina
  • The report provides the segmentation of the Refractory Angina epidemiology by Diagnosed Cases of CAD and RA in 7MM
  • The report provides the segmentation of the Refractory Angina epidemiology by Diagnosed Population of NORDA in 7MM
Report Highlights
  • 11-Year Forecast of Refractory Angina epidemiology
  • 7MM Coverage
  • Total Prevalent Cases of Refractory Angina
  • Prevalent Cases according to segmentation: Diagnosed Cases of NORDA, Gender-specific Cases and Sub-Type Specific Cases
  • Diagnosed cases of CAD and RA
KOL - Views

The publisher interviews, KOLs and SME's opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps to understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered
  • What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Refractory Angina?
  • What are the key findings pertaining to the Refractory Angina epidemiology across 7MM and which country will have the highest number of patients during the forecast period (2017-2030)?
  • What would be the total number of patients of Refractory Angina across the 7MM during the forecast period (2017-2030)?
  • Among the EU5 countries, which country will have the highest number of patients during the forecast period (2017-2030)?
  • At what CAGR the patient population is expected to grow in 7MM during the forecast period (2017-2030)?
  • What is the disease risk, burden and unmet needs of the Refractory Angina?
  • What are the current available treatments of Refractory Angina?
Reasons to Buy

The Refractory Angina Epidemiology report will allow the user to -
  • Develop business strategies by understanding the trends shaping and driving the global Refractory Angina market
  • Quantify patient populations in the global Refractory Angina market to improve product design, pricing, and launch plans
  • Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Refractory Angina therapeutics in each of the markets covered
  • Understand the magnitude of Refractory Angina population by its Sub-Types
  • The Refractory Angina epidemiology report and model were written and developed by Masters and PhD level epidemiologists
  • The Refractory Angina Epidemiology Model developed is easy to navigate, interactive with dashboards, and epidemiology based with transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over 11-year forecast period using reputable sources
Key Assessments
  • Patient Segmentation
  • Disease Risk and Burden
  • Risk of disease by the segmentation
  • Factors driving growth in a specific patient population
Geographies Covered
  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan
Study Period: 2017-2030

RA is not a disease, but a symptom of underlying heart problems. It is also called as chronic refractory angina pectoris (CRAP) which traditionally occurs in patients with advanced, often diffuse coronary artery disease that failed to be completely revascularized by percutaneous coronary intervention (PCI) and/or coronary artery bypass graft (CABG) with remaining angina pectoris symptoms despite maximized pharmacological intervention.

As suggested by Centers for Disease Control and Prevention, in United States about 18 million adults age 20 and older have coronary artery disease, which is accounted by about 7% of total population.

According to the American Heart Association, an estimated 16 million Americans aged 20 years and over have coronary artery disease. According to the 2016 American Heart Association report, there are approximately 15.5 million Americans with coronary artery disease, 50% of who have symptomatic angina pectoris.

Higher Prevalence of Refractory Angina is observed among males as compared to females in 7MM.

Refractory Angina (RA) prevalence is increasing globally and the case burden is expected to rise among adults in whom the disease is particularly fatal.
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1. Key Insights

2. Executive Summary of Refractory Angina

3. SWOT Analysis for Refractory Angina

4. Disease Background and Overview
4.1. Introduction
4.2. Types
4.3. Symptoms
4.4. Etiology
4.5. Risk Factors
4.6. Pathophysiology
4.7. Diagnosis

5. Epidemiology and Patient Population
5.1. Key Findings
5.2. 7MM Total Prevalent Patient Population of Refractory Angina [RA]
5.3. Epidemiology Assumptions and Rationale - 7MM

6. Country Wise-Epidemiology of Refractory Angina (RA)
6.1. The United States
6.1.1. Total Diagnosed Population of CAD and RA in the United States
6.1.2. Sub-type Specific Prevalence of RA in the United States
6.1.3. Gender specific Prevalence of RA in the United States
6.1.4. Diagnosed Population of NORDA in the US
6.2. Germany
6.2.1. Total Diagnosed Population of CAD and RA in Germany
6.2.2. Sub-type Specific Prevalence of RA in Germany
6.2.3. Gender specific Prevalence of RA in Germany
6.2.4. Diagnosed Population of NORDA in Germany
6.3. France
6.3.1. Total Diagnosed Population of CAD and RA in France
6.3.2. Sub-type Specific Prevalence of RA in France
6.3.3. Gender specific Prevalence of RA in France
6.3.4. Diagnosed Population of NORDA in France
6.4. Italy
6.4.1. Total Diagnosed Population of CAD and RA in Italy
6.4.2. Sub-type Specific Prevalence of RA in Italy
6.4.3. Gender specific Prevalence of RA in Italy
6.4.4. Diagnosed Population of NORDA in Italy
6.5. Spain
6.5.1. Total Diagnosed Population of CAD and RA in Spain
6.5.2. Sub-type Specific Prevalence of RA in Spain
6.5.3. Gender specific Prevalence of RA in Spain
6.5.4. Diagnosed Population of NORDA in Spain
6.6. The United Kingdom
6.6.1. Total Diagnosed Population of CAD and RA in the UK
6.6.2. Sub-type Specific Prevalence of RA in the UK
6.6.3. Gender specific Prevalence of RA in the United Kingdom
6.6.4. Diagnosed Population of NORDA in the United Kingdom
6.7. Japan
6.7.1. Total Diagnosed Population of CAD and RA in Japan
6.7.2. Sub-type Specific Prevalence of RA in Japan
6.7.3. Gender specific Prevalence of RA in Japan
6.7.4. Diagnosed Population of NORDA in Japan

7. Treatment
7.1. Pharmacological Therapies
7.2. Noninvasive Antianginal therapies
7.3. Invasive Antianginal therapies

8. Treatment Guidelines
8.1. European Society of Cardiology (ESC) Guidelines for Refractory Angina Patients
8.2. National Institute for Health and Clinical Excellence (NICE) guidelines
8.3. Canadian Cardiovascular Society (CCS) Guidelines

9. Unmet Needs

10. Case Studies
10.1. A Case of Refractory Angina
10.2. A Case Report of Refractory Angina

11. Organizations related with Refractory Angina

12. Appendix
12.1. Bibliography
12.2. Report Methodology

13. Publisher Capabilities

14. Disclaimer

15. About the Publisher

List of Tables
Table 1: Summary of Refractory Angina (RA) Epidemiology, and Key Events (2017-2030)
Table 2: Difference between Stable and Unstable Angina
Table 3: Probability of Coronary Artery Diseases and Associated Diagnostic Strategies
Table 4: Total Prevalent Patient Population of RA in 7MM (2017-2030)
Table 5: Diagnosed Population of CAD and RA in the United States (2017-2030)
Table 6: Sub-type Specific Prevalence of RA in the United States (2017-2030)
Table 7: Gender specific Prevalence of RA in the United States (2017-2030)
Table 8: Diagnosed Population of NORDA in the US (2017-2030)
Table 9: Total Prevalent Population of RA in Germany (2017-2030)
Table 10: Sub-type Specific Prevalence of RA in Germany (2017-2030)
Table 11: Gender specific Prevalence of RA in Germany (2017-2030)
Table 12: Diagnosed Population of NORDA in Germany (2017-2030)
Table 13: Diagnosed Population of CAD and RA in France (2017-2030)
Table 14: Sub-type Specific Prevalence of RA in France (2017-2030)
Table 15: Gender specific Prevalence of RA in France (2017-2030)
Table 16: Diagnosed Population of NORDA in France (2017-2030)
Table 17: Diagnosed Population of CAD and RA in Italy (2017-2030)
Table 18: Sub-type Specific Prevalence of RA in Italy (2017-2030)
Table 19: Gender specific Prevalence of RA in Italy (2017-2030)
Table 20: Diagnosed Population of NORDA in Italy (2017-2030)
Table 21: Diagnosed Population of CAD and RA in Spain (2017-2030)
Table 22: Sub-type Specific Prevalence of RA in Italy (2017-2030)
Table 23: Gender specific Prevalence of RA in Spain (2017-2030)
Table 24: Diagnosed Population of NORDA in Spain (2017-2030)
Table 25: Diagnosed Population of CAD and RA in the UK (2017-2030)
Table 26: Sub-type Specific Prevalence of RA in the UK (2017-2030)
Table 27: Gender specific Prevalence of RA in the United Kingdom (2017-2030)
Table 28: Diagnosed Population of NORDA in the UK (2017-2030)
Table 29: Diagnosed Population of CAD and RA in Japan (2017-2030)
Table 30: Sub-type Specific Prevalence of RA in Japan (2017-2030)
Table 31: Gender specific Prevalence of RA in Japan (2017-2030)
Table 32: Diagnosed Population of NORDA in Japan (2017-2030)
Table 33: Grading of Angina Pectoris

List of Figures
Figure 1: SWOT Analysis
Figure 2: Normal and Plaque Buildup Artery
Figure 3: Pictorial Representation of Different Types of Angina
Figure 4: Few of the causes of Chest Pain
Figure 5: Mechanisms and Pathways involved in Cardiac Chest Pain
Figure 6: The Heart-Brain Axis Model of Angina Physiopathology and Related Therapeutic Targets
Figure 7: Diagnosis of Chest Pain Symptoms according to Anginal Symptoms
Figure 8: Diagnostic Interventions
Figure 9: Definite Diagnosis
Figure 10: Total Prevalent Patient Population of RA in 7MM (2017-2030)
Figure 11: Diagnosed Population of CAD and RA in the United States (2017-2030)
Figure 12: Sub-type Specific Prevalence of RA in the United States (2017-2030)
Figure 13: Gender specific Prevalence of RA in the United States (2017-2030)
Figure 14: Diagnosed Population of NORDA in the US (2017-2030)
Figure 15: Diagnosed Population of CAD and RA in Germany (2017-2030)
Figure 16: Sub-type Specific Prevalence of RA in Germany (2017-2030)
Figure 17: Gender specific Prevalence of RA in Germany (2017-2030)
Figure 18: Diagnosed Population of NORDA in Germany (2017-2030)
Figure 19: Diagnosed Population of CAD and RA in France (2017-2030)
Figure 20: Sub-type Specific Prevalence of RA in France (2017-2030)
Figure 21: Gender specific Prevalence of RA in France (2017-2030)
Figure 22: Diagnosed Population of NORDA in France (2017-2030)
Figure 23: Diagnosed Population of CAD and RA in Italy (2017-2030)
Figure 24: Sub-type Specific Prevalence of RA in Italy (2017-2030)
Figure 25: Gender specific Prevalence of RA in Italy (2017-2030)
Figure 26: Diagnosed Population of NORDA in Italy (2017-2030)
Figure 27: Diagnosed Population of CAD and RA in Spain (2017-2030)
Figure 28: Sub-type Specific Prevalence of RA in Spain (2017-2030)
Figure 29: Gender specific Prevalence of RA in Spain (2017-2030)
Figure 30: Diagnosed Population of NORDA in Spain (2017-2030)
Figure 31: Diagnosed Population of CAD and RA in the UK (2017-2030)
Figure 32: Sub-type Specific Prevalence of RA in the UK (2017-2030)
Figure 33: Gender specific Prevalence of RA in the United Kingdom (2017-2030)
Figure 34: Diagnosed Population of NORDA in the UK (2017-2030)
Figure 35: Diagnosed Population of CAD and RA in Japan (2017-2030)
Figure 36: Sub-type Specific Prevalence of RA in Japan (2017-2030)
Figure 37: Gender specific Prevalence of RA in Japan (2017-2030)
Figure 38: Diagnosed Population of NORDA in Japan (2017-2030)
Figure 39: Treatments Addressing Myocardial Perfusion
Figure 40: Treatments Addressing Neural Processing
Figure 41: Treatment Landscape of Refractory Angina
Figure 42: Possible Combinations of Anti-anginal Drugs
Figure 43: Technique of enhanced external counterpulsation
Figure 44: Possible mechanisms responsible for the clinical benefit associated with EECP therapy
Figure 45: Pictorial Representation of Neuromodulation Targets
Figure 46: Pictorial Representation of Coronary Sinus Reducer
Figure 47: Clinical Assessment of Angina
Figure 48: Clinical assessment and the typicality of anginal pain
Figure 49: Unmet Needs of RA
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