Biometals in Autism Spectrum Disorders will be the first to focus on trace metals and autism. Compared to other references examining ASDs or metallomics, a focused presentation of the findings of abnormal metal homeostasis in ASD has not yet come to be. This book provides for readers an overview of current findings on trace metal biology with respect to its role in ASD etiology and discusses how abnormal trace metal biology may be a common factor of several genetic and non-genetic causes of ASDs considered unrelated in the past. This will open new vistas for the development of new therapies based on targeted manipulation of trace metal homeostasis and generate awareness that trace metal levels during pregnancy must be tightly monitored.
- Reviews the role of trace metals in brain development
- Summarizes research linking trace metals and autism
- Explores heterogenous phenotypes as a factor of genetic and non-genetic factors
- Includes animal and human stem research
- Contains many diagrams, tables, and flow charts
- Proposes future therapies based on biometal homeostasis
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1. Introduction to Metallomics: The Science of Biometals 2. Measuring Biometals 3. The history of metals in autism spectrum disorders 4. Essential trace metals and their function in brain development 5. Non-essential metals and their brain pathology 6. Biometals and nutrition in Autism Spectrum Disorders 7. Linking trace metal abnormalities to Autism
insights from epidemiological studies 8. The specific role of zinc in Autism Spectrum Disorder 9. Animal models for trace metal abnormalities
links to Autism 10. Animal models for Autism
links to biometals abnormalities 11. Human stem cell models linking biometals abnormalities and Autism 12. Extracerebral biometals in Autism Spectrum Disorders: the gut-brain axis 13. Biometal homeostasis as therapeutic strategy in Autism Spectrum Disorders 14. Future perspectives: Autism, a disorder of biometal imbalance?
Dr. Grabrucker received his MSc in Biology with a focus on genetics in 2005 from the Technical University of Munich (TUM), Germany. After obtaining his PhD in Molecular Medicine from Ulm University, Germany, he continued his research in Stanford University's Department of Psychiatry and Behavioral Sciences. In 2011, he returned to University of Ulm as Assistant Professor and served as Executive Director of the Neurocenter of Ulm University. He has been a tenured lecturer in the Department of Biological Sciences at the University of Limerick since 2017. He is a member of the Bernal Institute, and of the Health Research Institute of University of Limerick. Dr Grabrucker's lab was the first to establish a prenatal zinc deficiency model for autism spectrum disorder and characterize the molecular and behavioral phenotype. This work continues in his lab and since his PhD in 2009, he has published 1 book (in press), 8 book chapters and over 47 articles in peer reviewed journals, among them Nature, Brain, EMBO J, Am J Hum Genet, and Trends in Cell Biology, with over 2000 citations.