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?-Tertiary Amines en Route to Natural Products

  • ID: 5130639
  • Book
  • January 2021
  • 242 Pages
  • Elsevier Science and Technology
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?-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. The book covers the class of natural products bearing the ?,?-disubstituted ?-amino acid motif. Featured natural product molecules include Altemicidin, Amathaspiramide (A-F), Kaitocephalin, Lactacystin, Salinosporamide, Manzacidins (A,C), Neooxazolomycin, Sphingofungins (E,F), (1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid (ACPD), Total synthesis of cephalotaxine and related molecules, ?-amino acids based natural products, ? amino acid based natural products and Tetrodotoxin.

This book is ideal for chemists working in the area of organic synthesis, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis.

  • Outlines synthetic strategies for natural products bearing ?-tertiary amines and ?,?-disubstituted ?-amino acid motif
  • Describes multistep synthetic routes that highlight key steps
  • Covers asymmetric and diastereoselective synthetic approaches towards targeted natural products
  • Illustrates multistep synthetic routes related to -amino acids based natural products and -amino acids based natural products
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1. Introduction: ?,?-Disubsituted ?-Amino Acids 2. Altemicidin 3. Amathaspiramide(A-F) 4. Kaitocephalin 5. Lactacystin 6. Salinosporamide 7. Manzacidins (A, C) 8. Sphingofungins (E, F) Synthesis 9. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid) 10. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin 11. Introduction: ?,?-Disubsituted ?-Amino Acids 12. Altemicidin 13. Amathaspiramide(A-F) 14. Kaitocephalin 15. Lactacystin 16. Salinosporamide 17. Manzacidins (A, C) 18. Sphingofungins (E, F) Synthesis 19. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid) 20. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin

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Hameed, Abdul
Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow at Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. He worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). He is also the recipient of Gold Medal (2017/18) for Scientists under 40 in the Field of Chemistry by The Chemical Society of Pakistan. His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential.
Al-Rashida, Mariya
Dr. Mariya al-Rashida is a synthetic chemist and has expertise in the area of organic synthesis. She completed Ph.D. in chemistry from the Institute of Chemistry, University of the Punjab, Lahore, Pakistan in 2011. Her area of expertise is synthetic and computational medicinal chemistry. She is currently working towards the synthesis of metalloenzyme inhibitors (carbonic anhydrase, and ecto-nucleotidases). She is an Associate Professor and Chairperson of the Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. She has published more than 60 research articles with a cumulative Impact Factor > 150 in various peer review international journals. She has been the recipient of many awards including the prestigious CSP Gold Medal Award for Chemist Under 40.
Shah, Muhammad Raza
Muhammad Raza Shah is Full Professor at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research (CBSCR) and the recipient of numerous awards, including the civil award Tamgha-i-Imtiaz from the President of Pakistan, Salam prize, Prof. Atta ur Rahman gold medal and the Dr. M. Raziuddin Siddiqi Prize (2015) for Scientists under 40 in the Field of Chemistry by the Pakistan Academy of Sciences. He was selected TWAS Young Affiliate in 2010 by Third World Academy of Sciences. He has authored three books (Elsevier) and also edited two books (Elsevier) in addition contributing over 350 peer-reviewed journal papers with impact factor more than 820. One of his authored books was declared best book of year 2017 by Government of Pakistan, Higher Education Commission. He is fellow International Union of Pure and Applied Chemistry and Fellow the Chemical Society of Pakistan. He is editor the Journal of the Chemical Society of Pakistan. He is mentor of Pakistani International Chemistry Olympiad team since 2009. He is also member of National Nanotechnology Foresight Committee constituted by PCST. He remained a member of COMSTECH consultative working group of scientists from OIC countries, to prepare agenda and action plan for the Ten-Year Plan of Action (TYPOA 2016-2025).
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