+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

  • Book

  • August 2020
  • Elsevier Science and Technology
  • ID: 5146378

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.

Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.

Table of Contents

1. LC-MS characterization of antibody-based therapeutics: recent highlights and future prospects
2. Engineering of Protein A for improved purification of antibodies and Fc-fused proteins
3. High fidelity affinity purification of Fc-fusion molecules from product related impurities
4. Recent advances in continuous downstream processing of antibodies and related products
5. Recent advances in antibody-based monolith chromatography for therapeutic applications
6. Recent advances in harvest clarification for antibodies and related products
7. Recent advances in ultrafiltration and virus filtration for production of antibodies and related biotherapeutics
8. A roadmap for IgG-like bispecific antibody purification
9. High-throughput, parallelized and automated protein purification for therapeutic antibody development


Allan Matte Human Health Therapeutics, Research Center, National Research Council Canada, Montreal, QC, Canada. Allan Matte is a Senior Research Officer in the Downstream Processing Team in HHT. With over 30 years of involvement in scientific R&D, he has coauthored more than 70 original research articles, reviews, and book chapters in various areas of protein science. He has also presented at a number of national and international conferences in the areas of high-throughput structural biology and antibody purification