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Frontiers in Anti-Infective Drug Discovery: Volume 8

  • ID: 5188257
  • Book
  • October 2020
  • Bentham Science Publishers Ltd
This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships.

Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.

The eighth volume of this series features 8 chapters that cover methods for antimicrobial drug discovery (with 2 chapters that focus on genomics) as well as updates on drug development against Helicobacter pylori and emerging coronaviruses

Among other interesting topics:
  • Eradication of Helicobacter pylori Infection with Non-Bismuth Quadruple Concomitant Therapy
  • Drug Discovery Strategies Against Emerging Coronaviruses: A Global Threat
  • Opportunities Offered By Fragment-Based Drug Design in Antibiotic Development
  • Phage therapy as a Tool for Control of Foodborne Diseases: Advantages and Limitations
  • Subtractive Genomics Approaches: Towards Anti-Bacterial Drug Discovery
  • Recent Advances in the Discovery of Antimicrobials through Metagenomics
  • Phyto-Nano-Antimicrobials: Synthesis, Characterization, Discovery, and Advances
  • Aptamers as Anti-infective Agents
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Chapter 1 Eradication of Helicobacter Pylori Infection with Nonbismuth
  • Quadruple Concomitant Therapy
  • Introduction
  • Objective
  • Bibliographical Searches
  • Efficacy of the Concomitant Regimen
  • Comparison Between Concomitant and Standard Triple Regimen
  • Comparison Between Concomitant and Sequential Regimens
  • Effects of Different Variables on the Efficacy of Concomitant
  • Therapy
  • Clarithromycin Resistance
  • Nitroimidazole Resistance
  • Dual Clarithromycin and Metronidazole Resistance
  • Duration of Treatment
  • How Could We Even Increase the Efficacy of the Concomitant
  • Treatment?
  • What are the Results with the Concomitant Treatment In
  • Clinical Practice? the Experience of the European Registry on H.
  • Pylori Management
  • Conclusions
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
Chapter 2 Drug Discovery Strategies Against Emerging
  • Coronaviruses: a Global Threat
  • Introduction
  • Biological Aspects, Signs/Symptoms and Diagnosis for Mers-Cov,
  • Sars-Cov, and Sars-Cov-2
  • Strategies Used for Discovering New Potential Drugs
  • Natural Source
  • Classical Methods Applied for Discovering New Antiviral Agents
  • Virtual Screening and Computational Techniques for Designing New Antiviral Agents
  • Drug Repurposing
  • High-Throughput Screening (Hts) for Discovering New Antiviral Agents
  • Conclusion and Future Outlook
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
Chapter 3 Opportunities Offered by Fragment-Based Drug Design In
  • Antibiotic Development
  • Introduction
  • Potential Advantages of Fbdd for Development of Antibiotics
  • Case Studies of New Antibiotic Development Utilising Fbdd
  • Case Study 1: Β-Lactamase
  • Case Study 2: Bacterial Dna Gyrase/Topoisomerase Iv
  • Case Study 3: Fatty Acid Synthesis (Fas) Pathways
  • Biotin Carboxylase
  • Ketoacyl Synthase
  • Case Study 4: Mycobacterium Tuberculosis (Mtb)
  • Pantothenate Synthetase (Panc)
  • Mtb Transcriptional Repressor (Ethr)
  • Mycocyclosin Synthase (Cyp121)
  • Fructose 1,6-Bisphosphate Aldolase (Fba)
  • Recent Advances in Fbdd
  • Conclusion
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
Chapter 4 Phage Therapy as a Tool for Control of Foodborne
  • Diseases: Advantages and Limitations
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  • 􀀪􀁒q�􀁝I�􀁏h�􀁝􀀏􀀃􀀨􀀑􀀳􀀑􀀃􀀶􀁈j�􀁘u�
  • Introduction
  • Bacteriophage
  • History
  • General Phage Characteristics
  • Replication Cycle
  • Adsorption to the Bacterial Cell Wall
  • Replication
  • Release of Viral Progeny and Cell Lysis
  • Other Components in the Replication Cycle
  • Bacteriophage Use for Phage Therapy
  • Health Applications
  • Applications in the Food Industry
  • Bacteriophage Preparations
  • Indications and Limitations
  • Bacterial Resistance
  • Synergy Between Bacteriophages and the Immune System
  • Concluding Remarks
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
  • Introduction
  • Characteristics of an Ideal Drug Target
  • Significance of Drug Target Identification
  • Subtractive Genomics Based Efforts for Drug Target Identification
  • Approaches Used for Promising Drug Target Prediction
  • Drugsol and Its Utility
  • Non-Host Homologues
  • Subcellular Localization
  • Essentiality
  • Virulence
  • Annotation
  • Druggability Potential Evaluation
  • Analyses of Metabolic Pathways
  • Our Contribution
  • Sequence Acquisition
  • Human Homology Filter
  • Subcellular Localization
  • Essentiality
  • Virulence
  • Annotated
  • Druggability Potential Evaluation
  • Analyses of Metabolic Pathways
  • Physiochemical Properties
  • Pros and Cons of in Silico Drug Target Mining
  • Success Stories
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
Chapter 6 Recent Advances in the Discovery of Antimicrobials
  • Through Metagenomics
  • Introduction
  • Major Modular Enzymes and Their Associated Domains
  • Non-Ribosomal Peptide Synthetases (Nrps)
  • Polyketide Synthases (Pks)
  • Type I Pkss
  • Type Ii Pkss
  • Type Iii Pkss
  • Other Molecules
  • Exploration of New Habitats
  • Extreme Environment: a Niche for Novel Strains
  • Role of Metagenomics in Exploration of Uncultured Microbes
  • The Workflow of the Metagenomic Approach
  • Direct Metagenomic Screening Based on Function
  • Sequence-Based Metagenomic Screening
  • Sequence Advancement: Potential of Single-Cell Genomics and High-Throughput
  • Sequencing
  • Mining of Genomes: Current Scenario and Future Potential
Chapter 5 Subtractive Genomics Approaches: Towards Anti-Bacterial
  • Drug Discovery
  • Prediction of Biosynthetic Gene Cluster (Bgc) and Their Targeted Activation
  • Genetic Manipulations of the Biosynthetic Machinery for the Discovery of New
  • Antimicrobials
  • Different Mechanisms of Activation of Silent Bgcs
  • Antibiotic and Bioactive Compounds Discovered Through
  • Metagenomic Approach
  • Conclusion and Future Perspectives
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
Chapter 7 Phyto-Nano-Antimicrobials: Synthesis, Character-Ization,
  • Discovery, and Advances
  • Introduction
  • Synthesis of Nanoparticles
  • Bacterial Mediated Synthesis
  • Fungi Mediated Synthesis
  • Plant Extract Synthesis
  • Solvent for Synthesis
  • Mechanism of Synthesis
  • Characterization of Plant Mediated Nanoparticles Having
  • Microbial Activity
  • General Characterization
  • Uv- Visible Spectroscopy
  • X-Ray Diffraction
  • Transmission Electron Microscopy
  • Fourier Transformed Infrared
  • Dynamic Light Scattering
  • Characterization of Silver Nanoparticle (Agnps)
  • A). Uv-Visible Spectrophotometer
  • B). Ftir Analysis
  • C). Xrd Analysis
  • D). Thermogravimetric Analysis
  • E). Tem Analysis
  • F). Ftir Analysis
  • Characterization of Gold Nanoparticles (Aunps)
  • A). Uv- Vis Spectroscopy
  • B). Ftir
  • C). Sem
  • D). X-Ray Diffraction
  • Characterization of Iron Oxide Nanoparticle
  • A). Uv-Visible Spectroscopy
  • B). Atr Spectroscopy
  • C). Ft-Ir
  • D). Sem Analysis
  • E). Tem Analysis
  • F). X-Ray Diffraction
  • Zinc Oxide Nanoparticles
  • A). Uv-Visible Spectroscopy
  • B). Xrd Analysis
  • C). Ftir Analysis
  • D). Sem
  • E). Tem
  • Application of Nanoparticles
  • Silver Nanoparticles
  • Gold Nanoparticles
  • Oxide Nanoparticles
  • Antibacterial Property
  • Gold Nanoparticles
  • Oxide Nanoparticles
  • Medicinal Application
  • Future Prospects and Conclusion
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
Chapter 8 Aptamers as Anti-Infective Agents
  • 􀀰􀁘k�p�􀁐d�􀁇􀀃􀀤􀁏l�􀀃􀀶􀁜􀁈g�􀀏􀀃􀀱􀁜e�􀀃􀀤􀁏l�􀀏􀀃
  • Introduction
  • Aptamers
  • Systemic Evolution of Ligands by Exponential Enrichment (Selex)
  • Negative Selex
  • Counter Selex
  • Microfluidic Selex
  • Capillary Electrophoresis Selex
  • Cell Selex
  • Aptamers Versus Antibodies
  • Aptamers as Anti-Infective Agents Against Pathogenic
  • Microorganisms
  • Aptamers Against Pathogenic Bacteria
  • Aptamers Against Viruses
  • Aptamers Against Protozoan Parasites
  • Future Perspectives
  • Conclusion
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
  • Subject Index
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  • Atta-ur-Rahman
  • M. Iqbal Choudhary
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