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Cathepsin S - Pipeline Review, H2 2020

  • ID: 5189067
  • Drug Pipelines
  • October 2020
  • Region: Global
  • 29 pages
  • Global Markets Direct
1h Free Analyst Time

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FEATURED COMPANIES

  • F. Hoffmann-La Roche Ltd
  • Virobay Inc
  • MORE
Summary

According to the recently published report 'Cathepsin S - Pipeline Review, H2 2020'; Cathepsin S (CTSS or EC 3.4.22.27) pipeline Target constitutes close to 5 molecules. Out of which approximately 4 molecules are developed by companies and remaining by the universities/institutes.

Cathepsin S (CTSS or EC 3.4.22.27) - Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Cathepsin S has a role in itch and pain, or nociception. The nociceptive activity results from cathepsin S functioning as a signaling molecule via activation of protease-activated receptors 2 and 4 members of the G-protein coupled receptor family. Cathepsin S has a physiological role outside the lysosome. Immune cells, including macrophages and microglia, secrete cathepsin S in response to inflammatory mediators including lipopolysaccharides, proinflammatory cytokines and neutrophils.

The report 'Cathepsin S - Pipeline Review, H2 2020' outlays comprehensive information on the Cathepsin S (CTSS or EC 3.4.22.27) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies/Universities.

It also reviews key players involved in Cathepsin S (CTSS or EC 3.4.22.27) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase 0 and Preclinical stages are 1 and 3 respectively. Similarly, the universities portfolio in Discovery stages comprises 1 molecules, respectively. Report covers products from therapy areas Central Nervous System, Oncology, Gastrointestinal, Immunology and Metabolic Disorders which include indications Alzheimer's Disease, Autoimmune Disorders, Cancer Pain, Diabetic Retinopathy, Liver Fibrosis, Neuropathic Pain (Neuralgia), Pancreatic Cancer and Primary Biliary Cholangitis (Primary Biliary Cirrhosis).

Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope
  • The report provides a snapshot of the global therapeutic landscape for Cathepsin S (CTSS or EC 3.4.22.27)
  • The report reviews Cathepsin S (CTSS or EC 3.4.22.27) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Cathepsin S (CTSS or EC 3.4.22.27) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Cathepsin S (CTSS or EC 3.4.22.27) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Cathepsin S (CTSS or EC 3.4.22.27) targeted therapeutics
Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Cathepsin S (CTSS or EC 3.4.22.27)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Cathepsin S (CTSS or EC 3.4.22.27) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Note: Product cover images may vary from those shown
2 of 3

FEATURED COMPANIES

  • F. Hoffmann-La Roche Ltd
  • Virobay Inc
  • MORE
Introduction
  • Report Coverage
Cathepsin S (CTSS or EC 3.4.22.27) - Overview

Cathepsin S (CTSS or EC 3.4.22.27) - Therapeutics Development
  • Products under Development by Stage of Development
  • Products under Development by Therapy Area
  • Products under Development by Indication
  • Products under Development by Companies
  • Products under Development by Universities/Institutes
Cathepsin S (CTSS or EC 3.4.22.27) - Therapeutics Assessment
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type
Cathepsin S (CTSS or EC 3.4.22.27) - Companies Involved in Therapeutics Development
  • F. Hoffmann-La Roche Ltd
  • Virobay Inc
Cathepsin S (CTSS or EC 3.4.22.27) - Drug Profiles

RO-5461111 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
Small Molecule to Inhibit Cathepsin S for Oncology - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
VBY-285 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
VBY-50365 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
VBY-825 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
Cathepsin S (CTSS or EC 3.4.22.27) - Dormant Products

Cathepsin S (CTSS or EC 3.4.22.27) - Discontinued Products

Cathepsin S (CTSS or EC 3.4.22.27) - Product Development Milestones
  • Featured News & Press Releases
  • Nov 14, 2014: Virobay To Present Data On Two Cathepsin S Inhibitor Programs In Neuropathic Pain And Alzheimer's Disease At The 2014 Society For Neuroscience Annual Meeting
  • Nov 14, 2011: Virobay's Spectrum-Selective Cathepsin Inhibitor Shows Efficacy In Bone Cancer Model
Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact
  • Disclaimer
List of Tables
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Indication, H2 2020
  • Number of Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020
  • Number of Products under Investigation by Universities/Institutes, H2 2020
  • Products under Investigation by Universities/Institutes, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Stage and Route of Administration, H2 2020
  • Number of Products by Stage and Molecule Type, H2 2020
  • Pipeline by F. Hoffmann-La Roche Ltd, H2 2020
  • Pipeline by Virobay Inc, H2 2020
  • Dormant Products, H2 2020
  • Dormant Products, H2 2020 (Contd..1), H2 2020
  • Discontinued Products, H2 2020
List of Figures
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Top 10 Indications, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Stage and Route of Administration, H2 2020
  • Number of Products by Stage and Molecule Type, H2 2020
Note: Product cover images may vary from those shown
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  • F. Hoffmann-La Roche Ltd
  • Virobay Inc
Note: Product cover images may vary from those shown
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